Peter W. Grabham, Ph.D.

 Center for Radiological Research

Contact Information: 

Center for Radiological Research
630 West 168th Street, VC 11-243
New York, N.Y. 10032

Tel: 212-305-0845
Fax: 212-305-3229 

Email: pwg2@cumc.columbia.edu

Education

Undergraduate:

Bsc (hons), Wolverhampton University, UK

Graduate:

Ph.D, University of Birmingham, UK

Research

Effects of ionizing radiation on the structure and function of 3-dimensional vessel models.

Bystander response in vessel tissue models.

Effects of ionizing radiation on cell motility and the cytoskeleton.

Publications

Sharma P, Guida P, Grabham P. Effects of Fe particle irradiation on human endothelial barrier structure and function. Life Sci in Space Res. 2:  29-37. (2014)

Sharma P., Templin T., Grabham P. Short-term effects of gamma radiation on endothelial barrier function: uncoupling of PECAM-1.  Microvasc. Res. 86, 11-20. (2013). PMID: 23220351 (PMCID Pending).

Grabham P.W, Sharma P, and Geard CR. (2013) Two distinct types of the inhibition of vasculogenesis by different species of charged particles. Vascular Cell 5, 16. 

Grabham P.W, and Sharma P. (2013) The effects of radiation on angiogenesis. Vascular Cell , 5:19.

Grabham P.W, B. Bigelow A, and C. Geard. (2012) Effects of ionizing radiation on DNA repair dynamics in 3-Dimensional human vessel models: Differential effects according to radiation quality.  International Journal of Radiation Biology 88: 493-500. PMID: 22449005 (PMCID Pending)

Grabham P.W, B. Hu, P. Sharma, and C. Geard. Effects of ionizing radiation on 3-Dimensional human vessel models: Differential effects according to radiation quality and cellular development. Radiation Research 175: 21-28. PMID: 21175343 (2011) (PMCID Pending)

Hu B, Grabham P, Nie J , Balajee AS,  Zhou H, Hei TK, Geard CR (2011) Intrachromosomal changes and genomic instability in site-specific microbeam irradiated and bystander human-hamster hybrid cells.Radiation  Research 177 25-34. PMCID 3410536

Grabham PW, Seale GE, Bennecib M, Goldberg DJ and Vallee RB. Cytoplasmic dynein and LIS1 are required for microtubule advance during growth cone remodeling and fast axonal outgrowth. J Neurosci 27:5823-34, 2007. 

Grabham PW, Wu F, Schacher S and Goldberg DJ. Initiating morphological changes associated with long-term facilitation in Aplysia is independent of transcription or translation in the cell body. J Neurobiol 64:202-12, 2005.

Rybin VO, Grabham PW, Elouardighi H and Steinberg SF. Caveolae-associated proteins in cardiomyocytes: caveolin-2 expression and interactions with caveolin-3. Am J Physiol Heart Circ Physiol 285:H325-32, 2003.

Grabham PW, Foley M, Umeojiako A and Goldberg DJ. Nerve growth factor stimulates coupling of beta1 integrin to distinct transport mechanisms in the filopodia of growth cones. J Cell Sci 113 ( Pt 17):3003-12, 2000. 

Goldberg DJ, Foley MS, Tang D and Grabham PW. Recruitment of the Arp2/3 complex and mena for the stimulation of actin polymerization in growth cones by nerve growth factor. J Neurosci Res 60:458-67, 2000. 

Goldberg DJ and Grabham PW. Braking news: calcium in the growth cone. Neuron 22:423-5, 1999.

Grabham PW and Goldberg DJ. Nerve growth factor stimulates the accumulation of β1 integrin at the tips of filopodia in the growth cones of sympathetic neurons. J Neurosci 17:5455-65, 1997.

Grabham PW, Wu D-Y and Goldberg DJ. Protein tyrosine phosphorylation in the growth cone. In: Nerve Growth and Guidance, ed. C. McCaig, Portland Press, pp. 7-19, 1996.

Grand RJ, Turnell AS and Grabham PW. Cellular consequences of thrombin-receptor activation. Biochem J 313 ( Pt 2):353-68, 1996.

Grabham P and Cunningham DD. Thrombin receptor activation stimulates astrocyte proliferation and reversal of stellation by distinct pathways: involvement of tyrosine phosphorylation. J Neurochem 64:583-91, 1995.