Recent Research Findings

- The tumor suppressor function of the Betaig-h3 gene, originally established in human lung cancer samples, has now been extended to two other major tumor types including prostate and breast cancer. These findings provide a potential diagnostic and therapeutic target for the management of these cancers.

- Based on mechanistic findings that arsenic-induced genetic damages are mediated by reactive oxygen species, clinical trials to ascertain the chemo-preventive effects of selenium and vitamin A in the management of arsenic induced keratosis have been initiated by Columbia investigators in collaboration with WHO in Bangladesh.

- Sponsored by a grant from NASA, investigations demonstrated that mice haploinsufficient for the Atm gene were more susceptible to cataracts caused by heavy Fe ions than their wild-type counterparts.

- Short term, low doses of sodium arsenite treatment may induce a high frequency of apoptosis in metastatic melanoma that is non-responsive to radiotherapy and chemotherapy providing a new ray of hope for such patients.

- The Columbia microbeam development continues to be a major research resource for the Center. Recent findings include the detection of reactive oxygen and nitrogen species in targeted cytoplasmic irradiation, which mediate the genotoxic response in the nucleus of the irradiated cells, the ability of cytoplasmic irradiation to induce a bystander response and the identification of specific genes that are associated with bystander mutagenic signaling.