Foramen Ovale and Stroke Study:
A case control study
This study is funded by a grant from the National Institute of Health
NIH Grant NINDS: RO1-RO1-33248
Principal Investigator: Marco Di Tullio, MD
E-mail:
ditulli@medicine.cpmc.columbia.edu
Study Design
- Population-based case-control study
- 300 patients with first symptomatic ischemic stroke
- 300 community controls matched by age, gender and race/ethnicity
- Cases and controls drawn form the Northern Manhattan Stroke Study (NOMASS) over a 3-yr period
Primary Aims
To determine if PFO is:
- A risk factor for ischemic stroke, and especially cryptogenic stroke, in patients unselected for age
- Associated with DVT in stroke patients
- Associated with hypercoagulable states in stroke patients
Secondary Aims
- To determine if hypercoagulable states are a risk factor for ischemic stroke
- To determine the 2-year stroke recurrence risk in stroke patients with PFO and in those without it
Diagnostic Tests
Transthoracic echocardiography with aerated saline injection in cases and controls
Image-directed Doppler ultrasound examination of the lower extremities in cases
Hypercoagulable Battery
- Prothrombin fragment F1.2
- Antiphospholipid Antibodies (IgG and IgM)
- Lupus Anticoagulant
- Functional Protein S and C4b binding protein
E-mail: ditulli@medicine.cpmc.columbia.edu
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This Web site is currently maintained by Michael Zhang.
© New York Presbyterian Medical Center, Adult Echocardiography Lab, Columbia
University
Last revised
02/29/2008
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