Investigator Title Department Interests Penelope A. Boyden, Ph.D. Professor Pharmacology Electrophysiologic basis of arrhythmias Wendy Chung, M.D., Ph.D. Assistant Professor Pharmacology Genetics of cardiovascular disease Jeanine D’armiento M.D., PhD. Assistant Professor Medicine The role of matrix metalloproteinases in the pathogenesis of heart failure Heather S. Duffy, M.D. Research Scientist Pharmacology Mechanisms for cardiac arrhythmias Henry N. Ginsberg, M.D. Irving Professor of Medicine Medicine The molecular and cellular regulation of hypertriglyceridemia, particularly in patients and animal models of insulin resistance and diabetes Ira Goldberg, M.D. Professor Medicine Lipid uptake by tissues and mechanisms of atherogenesis Silviu Itescu, M.D. Associate Professor, Director of Transplantation Immmunology Medicine and Surgery Stem cell biology, angiogenesis and cardiovascular disease Robert Kass, Ph.D. Chairman, Hosack Professor of Pharmacology Pharmacology Regulation of ion channel expression in normal and genetically-altered cardiac cells: gene-targeted pharmacology of inheritedcardiac arrhythmias John D. Lioke, Ph.D. Co-director of Graduate Studies Physiology and Cellular Biophysics Regulation of leukocyte responses to inflammation Andrew Marks, M.D Chairman, Clyde and Helen Wu Professor of Molecular Cardiology Physiology and Cellular Biophysics Medicine Molecular biology of intracellular calcium release Channels and their relevance to human disease Steven Marx, M.D. Assistant Professor Medicine Ion channel regulation by macromolecular complexes Geoffrey S. Pitt, M.D. Assistant Professor Medicine and Pharmacology Molecular and biophysical studies ofcalcium regulation ofion channel structure and function Richard B. Robinson, Ph.D. Professor Pharmacology Elucidation of the processes that control developmental regulation of cardiac ion channel expression and cardiac autonomic responsiveness. Use of the above to design gene- and cell- based therapies for cardiac disease Michael Rosen, M.D. Pfeiffer Professor of Pharmacology and Pediatrics Director, Center for Molecular therapeutics Pharmacology, Pediatrics Developmental biology of the heart; cardiac-autonomic interactions; mechanisms of cardiac arrhythmias and their prevention and control Christian Schindler, M.D., Ph.D Associate Professor of Microbiology and Medicine Associate Professor of Microbiology and Medicine immunity with a focus on the JAK-STAT pathway. Dr. Schindler’s  utilizes multiple mouse models including that of atherogenesis Anne Marie Schmidt Chief, Division of Surgical Science Surgery RAGE signaling and the Pathogenic impact of RAGE modification Susan F. Steinberg Professor of Pharmacology and Pediatrics Signal transduction that mediates the cardiac actions of G-protein coupled receptors for catecholamines and thrombin Ira Tabas, M.D. Professor Medicine, Anatomy and Cell Biology The cellular and molecular biology of macrophages during atherogenesis Alan R. Tall, M.D. Tilden Weger Bieler Professor Medicine Basic aspects of the pathogenesis of atherosclerosis and Alzheimer’s disease Andrew L. Wit, M.D Professor Pharmacology Mechanisms for cardiac arrhythmias