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Team: Staff Profile

Gloria H. Su, PhD

Address:	Irving Cancer Research Center 1130 St. Nicholas Avenue 10-04 New York, NY 10032
Phone:	212.851.4624
Fax:	212.851.4627

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Positions and Appointments

2006 – Present	Executive Board Member, The Pancreas Center NewYork-Presbyterian Hospital/Columbia University
2003 – Present	Faculty, Herbert Irving Comprehensive Cancer Center Columbia University Medical Center
2003 – Present	Principal Investigator, Molecular Oncology Laboratory, Departments of Otolaryngology/H&N Surgery Columbia University College of Physicians and Surgeons
2003 – Present	Assistant Professor, Departments of Otolaryngology/H&N Surgery and Pathology Columbia University College of Physicians and Surgeons, New York, NY

The Pancreas Center Specialty

Basic Science

Education and Training

1997 – 2000	Post-Doctoral Fellow The Johns Hopkins University, Baltimore, MD
1992 – 1997	Ph.D. Committee on Immunology University of Chicago, Chicago, IL
1988 – 1992	B.A., Dept. of Biological Sciences, Northwestern University, Evanston, IL

Professional Experience

2001 – 2003	The Research Advisory Council of the Department of Pathology, The Johns Hopkins University, Baltimore, MD
2001 – 2003	Principal Investigator, GI Pathology, Department of Pathology, The Johns Hopkins University School of Medicine

Professional Honors

2002 – 2007	The Howard Temin Award, NIH/NCI.
2001	The David H. Bernstein Idea Award for Promising Young Scientists
2000	Career Development Award of the NIH Specialized Program of Research Excellent (SPORE)
1999	The First Annual Young Investigators' Day Award, Department of Pathology, The Johns Hopkins University
1997 – 2000	NIH SPORE Training Grant
1996	The American Society of Hematology Travel Award
1994 – 1997	NIH Genetic Training Grant
1992 – 1994	Baxter Fellowship
1991	Emerging Leader Certificate, Norris Student Center, Northwestern University

Recent Committee Memberships and Professional Societies

2007	Peer Review Study Session, Department of Defense (DOD)–Congressionally Directed Medical Research Programs (CDMRP)
2002	Co-chair, NIH GI Joint MMHCC-SPORE Meeting, Washington, D.C.
2001 – Present	The Editorial Board of the International Journal of Gastrointestinal Cancer, Humana Press.
2000 – Present	American Association for Cancer Research
1998 – 1999	Treasurer, The Johns Hopkins Postdoctoral Association

Current Projects

2008 – 2010	NIH R21 (Principal Investigator), The tumor-suppressive role of ALK4/ACVR1B in pancreatic tumorigenesis.
2007 – 2008	PanCan Pilot Grant (Principal Investigator), Activin signaling in the development of pancreatic cancer precursor lesions.
2004 – 2009	NIH R01 (Principal Investigator), Mouse Model for Human Pancreatic Ductal Adenocarcinoma.

Selected Publications

D. J. Lenshow, G. H. Su, L. A. Zuckerman, N. Nabavi, C. L. Jellis, G. S. Gray, J. Miller, J. A. Bluestone. Expression and functional significance of an additional ligand for CTLA-4. Proc. Natl. Acad. Sci. USA 1993; 90:11054-11058

M. C. Olson, E. W. Scott, A. A. Hack, G. H. Su, H. Singh, M. C. Simon. PU.1 is not essential for early myeloid gene expression but is required for terminal myeloid differentiation. Immunity 1995; 3:703-714

J. V. Schmidt, G. H. Su, J. K. Reddy, M. C. Simon, C. A. Bradfield. Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development. Proc. Natl. Acad. Sci. USA 1996; 93:6731-6736

G. H. Su, H. S. Ip, B. S. Cobb, M. Lu, H. Chen, M. C. Simon. The Ets protein Spi-B is expressed exclusively in B cells and T cells during development. Journal of Experimental Medicine 1996; 184:203-214

L. L. Peter, S. L. Ciciotte, G. H. Su, M. C. Simon. The gene encoding the transcription factor Spi-B maps to mouse chromosome 7. Mammalian Genome 1997; 8:452-453

G. H. Su, H-M Chen, N. Muthusamy, L. A. Garrett-Sinha, D. Baunoch, D. G. Tenen, M. C. Simon. Defective B cell receptor-mediated responses in mice lacking the Ets protein, Spi-B. The EMBO Journal 1997; 16:7118-7129

G. H. Su, W. Hilgers, M. C. Sheker, D. J. Tang, C. J. Yeo, R. H. Hruban, S. E. Kern. Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene. Cancer Research 1998; 58:2339-2342

L. A. Garrett-Sinha, G. H. Su, S. Rao, S. Kabak, Z. Hao, M. R. Clark, M. C. Simon. PU.1 and Spi-B are required for normal B cell receptor (BCR)-mediated signal transduction. Immunity 1999; 10:399-408

G. H. Su, R. H. Hruban, R. K. Bansal, G. S. Bova, D. J. Tang, M. C. Sheker, A. M. Westerman, M. M. Entius, M. Goggins, C. J. Yeo, S. E. Kern. Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers. American Journal of Pathology 1999; 154:1835-1840

W. Hilgers, G. H. Su, B. G. Koerkamp, D. J. Tang, M. C. Shekher, A. Y. Sugar, C. J. Yeo, R. H. Hruban, S. E. Kern. Novel homozygous deletions of chromosomal band 18q22 in pancreatic adenocarcinoma identified by STS marker scanning. Genes Chromosomes Cancer 1999; 25:370-375.

R. E. Wilentz, G. H. Su, J. L. Dai, A. B. Sparks, P. Argani, T. A. Sohn, C. J. Yeo, S. E. Kern, R. H. Hruban. Immunohistochemical labeling for Dpc4 mirrors genetic status in pancreatic and peripancreatic adenocarcinomas: a new marker of DPC4 inactivation. American Journal of Pathology 2000, 156:37-43.

G. H. Su, T. A. Sohn, B. Ryu, S. E. Kern. A novel histone deacetylase inhibitor identified by high-throughput transcriptional screening of a compound library. Cancer Research 2000, 60:3137-42.

G. H. Su, R. Bansal, K. M. Murphy, E. Montgomery, C. J. Yeo, R. H. Hruban, S. E. Kern. ACVR1B (ALK4, activin receptor type 1B) gene mutations in pancreatic carcinoma. Proc. Natl. Acad. Sci. USA 2001, 98: 3254-7.

P. Argani, A. Shaukat, M. Kaushal, R. E. Wilentz, G. H. Su, T. A. Sohn, C. J. Yeo, J. L. Cameron, S. E. Kern, R. H. Hruban. Differing rates of loss of DPC4 expression and of p53 overexpression among carcinomas of the proximal and distal bile ducts. Cancer 2001, 91:1332-41.

T. A. Sohn, G. H. Su, B. Ryu, C. J. Yeo, S. E. Kern. High-throughput drug screening of the DPC4 tumor-suppressor pathway in human pancreatic cancer cells. Annals of Surgery 2001, 233: 696-703.

G. H. Su, J. J. Song, E. A. Repasky, M. Schutte, S. E. Kern. Mutation fate of MAP2K4/MKK4 in breast carcinoma. Human Mutation 2002, 19:81.

T. A. Sohn, R. Bansal, G. H. Su, K. M. Murphy, S. E. Kern. High-throughput measurement of the Tp53 response to anticancer drugs and random compounds using a stably integrated Tp53-responsive luciferase reporter. Carcinogenesis 2002, 23:949-58.

N. Sato, N. Maehara, G. H. Su, M. Goggins. Effects of 5-aza-2'-deoxycytidine on matrix metalloproteinase expression and pancreatic cancer cell invasiveness. JNCI 2003, 95:327-30.

F. Sahin, A. Maitra, P. Argani, N. Sato, N. Maehara, E. Montgomery, M. Goggins, R. H. Hruban, G. H. Su. Loss of Stk11/Lkb1 expression in pancreatic and biliary neoplasms. Modern Pathology 2003, 16:686-91.

N. Fukushima, N. Sato, F. Sahin, G. H. Su, R. H. Hruban, and M. Goggins. Aberrant methylation of suppressor of cytokine signaling (SOCS-1) gene in pancreatic ductal neoplasms. Br J Cancer 2003, 89:338-43.

N. Sato, N. Fukushima, N. Maehara, H. Matsubayashi, J. Koopmann, G. H. Su, R. H. Hruban, M. Goggins. SPARC/osteonectin is a frequent target for aberrant methylation in pancreatic adenocarcinoma and a mediator of tumor-stromal interactions. Oncogene 2003, 22:5021-30.

H. Ghaffar, F. Sahin, M. Sanchez-Cepedes, G.H. Su, M. Zahurak, D. Sidransky, and W. H. Westra. LKB1 Protein Expression in the Evolution of Glandular Neoplasia of the Lung. Clin Cancer Research 2003, 9:2998-3003.

A. R. Parker, R. N. O'Meally, F. Sahin, G. H. Su, W. G. Nelson, T. L. DeWeese, and J. R. Eshleman. Defective human MutY phosphorylation exists in colorectal cancer cell lines with wild-type MutY alleles. J. Biol Chem 2003, 278:47937-45.

N. Fujiuchi, J. A. Aglipay, T. Ohtsuka, N. Maehara, F. Sahin, G. H. Su, S. W. Lee, T. Ouchi. Requirement of IFI16 for the maximal activation of p53 induced by ionizing radiation. J Biol Chem. 2004, 279:20339-44.

R. Kannangai, F. Sahin, O. Adegbola, R. Ashfaq, G. H. Su, M. Torbenson. FHIT mRNA and protein expression in hepatocellular carcinoma. Mod Pathol. 2004, 17:653-9.

F. Sahin, R. Kannangai, O. Adegbola, J. Wang, G. Su, M. Torbenson. mTOR and P70 S6 kinase expression in primary liver neoplasms. Clin Cancer Res. 2004 10:8421-5.

W. Xin, K. J. Yun, F. Ricci, M. Zahurak, W. Qiu, G. H. Su, C. J. Yeo, R. H. Hruban, S. E. Kern, C. A. Iacobuzio-Donahue. MAP2K4/MKK4 expression in pancreatic cancer: genetic validation of immunohistochemistry and relationship to disease course. Clin Cancer Res 2004, 10:8516-20.

G. S. Bova, I. A. Eltoum, J. A. Kiernan, G. P. Siegal, A. R. Frost, C. J. Best, J. W. Gillespie, G. H. Su, M. R. Emmert-Buck. Optimal molecular profiling of tissue and tissue components: defining the best processing and microdissection methods for biomedical applications. Mol Biotechnol. 2005, 29:119-52.

F. Sahin, W. Qiu, R. E. Wilentz, C. A. Iacobuzio-Donahue, A. Grosmark, G. H. Su. RPL38, FOSL1, and UPP1 are predominately expressed in the pancreatic ductal epithelium. Pancreas 2005, 30:158-67.

W. Qiu, F. Schönleben, H. M. Thaker, M. Goggins, G. H. Su. A novel mutation of STK11/LKB1 gene leads to the loss of cell growth inhibition in head and neck squamous cell carcinoma. Oncogene 2006, 25:2937-42.

W. Qiu, , X. Li, D. J. Ho, L. G. Close, S. Manolidis, B. P. Bennett, G. H. Su. PIK3CA mutations in head and neck squamous cell carcinoma. Clinical Cancer Research 2006, 12:1441-6.

F. Schönleben, W. Qiu, N. T. Ciau, D. J. Ho, X. Li, J. D. Allendorf, H. E. Remotti, G. H. Su. PIK3CA mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) of the pancreas. Clinical Cancer Research 2006, 12:3851-5.

H. Fenton, B. Carlile, E. A. Montgomery, H. Carraway, J. Herman, F. Sahin, G. H. Su, P. Argani. LKB1 protein expression in human breast cancer. Appl Immunohistochem Mol Morphol 2006, 14:146-53.

W. Qiu, F. Schönleben, X. Li, G. H. Su. Disruption of Transforming Growth Factor ?-Smad signaling pathway in head and neck squamous cell carcinoma as evidenced by mutations of SMAD2 and SMAD4. Cancer Letter 2007 Jan 8; 245(1-2):163-70. Epub 2006 Feb 14.

F. Schönleben, W. Qiu, K. C. Bruckman, N. T. Ciau, X. Li, M. H. Lauerman, H. Frucht, J. A. Chabot, J. D. Allendorf, H. E. Remotti, G. H. Su. BRAF and KRAS gene mutations in intraductal papillary mucinous neoplasm/carcinoma (IPMN/IPMC) of the pancreas. Cancer Letters 2007 May 8; 249(2):242-8. Epub 2006 Nov 9.

W. Qiu, G.-X. Tong, S. Manolidis, L. G. Close, A. M. Assaad, G. H. Su. Novel mutant-enriched sequencing identified high frequency of PIK3CA mutations in pharyngeal cancer. International Journal of Cancer 2008. Epub 2007 Nov 7.

F. Schönleben, J. D. Allendorf, W. Qiu, X. Li, D. J. Ho, N. T. Ciau, R. L. Fine, J. A. Chabot, H. E. Remotti, G. H. Su. Mutational analyses of multiple oncogenic pathways in intraductal papillary mucinous neoplasms of the pancreas. Pancreas 2008 (In Press).

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