Analysis of genetic variation in candidate genes for complex disorders, such as AMD, and genes involved in eye disorders of Mendelian inheritance
. (Allikmets)
Development of microarray-based screening technologies,
"
gene chips
"
and
"
disease chips
"
.
(Allikmets)
New therapeutic approaches for eye diseases, including lentiviral gene therapy and small molecule drugs
(Allikmets)
Retinal and RPE transplantation
. (Del Priore)
RPE repopulation of Bruch's membrane in vitro
. (Del Priore)
Effects of diseased Bruch's membrane on RPE gene expression
(Del Priore)
Determining the molecular mechanism(s) of ocular aging and the role of light and oxygen in various eye diseases such as cataract formation in the lens and macular degeneration in the retina
(Dillon)
Epidemiological investigation of the effect of cataract removal on AMD
. (Dillon)
Non-invasive detection of oxygen tension in the eye
. (Dillon)
Assessment of whether transepithelial fluid transport takes place by local osmosis or electro-osmosis. This work uses a variety of techniques including epithelial electrophysiology, molecular biology and biochemistry, cell biology and theoretical biology
. (Fischbarg)
Study of function and modeling of 3D structure of facilitative glucose transporters. Structure and water permeability of membrane proteins
. (Fischbarg)
Gene therapy and cell transplantation to treat retinal degeneration
. (Gouras)
Utilize lentiviral vectors to deliver therapeutic genes to the retina
. (Gouras)
Treat mouse models of Leber Congenital Amaurosis and Stargardt Dystrophy by gene therapy
(Gouras)
Electrophysiology of rods and cones in mice and men
. (Gouras)
Characterization of cell movement in the cornea with in vivo time lapse microscopy
. (Nagasaki)
Physiological and biochemical analysis of cytotoxic tear factors which affect the cells of the corneal stroma
. (Nagasaki)
Impact of non-enzymatic nitration (NEN) of connective tissue proteins on the aging process and development of age/smoking related non-cancer chronic disease
. (Paik)
Examining the structure, function, and retinal expression of a family of putative neural cell adhesion proteins called protocadherins
. (Shapiro)
Investigating the biology of tubby proteins, which have been shown to function as signalin factors downstream from heterotrimeric G-proteins
. (Shapiro)
Biochemical origin of the dysfunction of tubby protein mutants
. (Shapiro)
Studies of a causal link between the intracellular accumulation of aging pigments (lipofuscin) in the RPE and the death of those cells
. (Sparrow)
Mechanisms involved in A2E biosynthesis and conditions under which the formation of A2E may be accelerated
. (Sparrow)
Development of perfluorocarbon liquids for intravitreal use in the surgical treatment of complicated retinal detachment
(Sparrow)
Quantification of drusen and geographic atrophy in fundus photographs
(Sparrow)
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