faculty & research

Faculty

The name of each faculty member is linked to a more detailed description of that person's research interests

Faculty Member Affiliations Research Interests

Richard Axel

Axel, Richard

Email: ra27@columbia.edu                          Phone: 212-305-6915                                 Fax: 212-923-7249                                     Location: HHSC Rm. 1014

University Professor, Biochemistry & Molecular Biophysics, Neuroscience, Pathology & Cell Biology
Investigator, Howard Hughes Medical Institute

Defining the logic of olfactory perception; how individual sensory neurons express a specific receptor and how the brain distinguishes which receptors have been activated

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Califano, Andrea

Email: califano@c2b2.columbia.edu              Phone: 212-851-183                                   Fax: 212-305-9500                                     Location: C2B2 Rm. 912    

Professor of Systems Biology in the Department of Biochemistry and Molecular Biophysics, in the Institute for Cancer Genetics, and in the Department of Biomedical Informatics. Director, Columbia Initiative in Systems Biology Director, JP Sulzberger MD Columbia Genome Center Associate Director, Herbert Irving Comprehensive Cancer Center

Dissecting and interrogating the regulatory logic of the cancer cell using a combination of high-throughput experimental and computational systems biology approaches. Identifying master regulators of stem cell pluripotency and lineage specific differentiation. 

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JOACHIM FRANK

Frank, Joachim

Email: jf2192@columbia.edu
Phone: 212-305-9510                           Fax: 212-305-9500
Location: BB Rm. 221

Professor of Biochemistry & Molecular Biophysics and Biological Sciences
Investigator, Howard Hughes Medical Institute

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction. Using these methods, and flexible fitting of X-ray structures, the dynamics of the decoding and translocation mechanisms are revealed.

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STEPHEN P. GOFF

Goff, Stephen P.

Email: spg1@columbia.edu
Phone: 212-305-3794                           Fax: 212-305-5106
Location: HHSC Rm. 1310

Higgins Professor of Biochemistry and Molecular Biophysics and Professor of Microbiology
Investigator, Howard Hughes Medical Institute

Retroviral replication; tyrosine kinase oncogenes

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MAX E. GOTTESMAN

Gottesman, Max E.

Email: meg8@columbia.edu
Phone: 212- 305-6900                          Fax: 212-305-1741                        Location: HHSC Rm. 1504

Charles H. Revson Professor of Biochemistry and Molecular Biophysics and Microbiology (in the Institute of Cancer Research); Director - Institute Cancer Research

Regulation of transcription termination in /E. coli/ and bacteriophage; DNA damage repair and signal transduction in eukaryotes.

 

ERIC C. GREENE

Greene, Eric C.

Email: ecg2108@columbia.edu
Phone: 212-342-2944                          Fax:  212-305-5427                       Location: BB Rm. 536

Associate Professor Biochemistry & Molecular Biophysics
Investigator, Howard Hughes Medical Institute

 

Molecular mechanisms of DNA recombination and repair; single molecule fluorescence microscopy and other biochemical approaches.

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IVA GREENWALD

Greenwald, Iva

Email: isg4@columbia.edu
Phone: 212-305-6928                           Fax: 212-305-1721                        Location: HHSC Rm. 720A

Professor of Biochemistry & Molecular Biophysics and Genetics & Development
Investigator, Howard Hughes Medical Institute

LIN-12/Notch signaling and cell-cell interactions during development.

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ALLA GRISHOK

Grishok, Alla

Email: ag2691@columbia.edu
Phone: 212-305-9893                           Fax: 212-304-5707                        Location: HHSC Rm. 611

Assistant Professor of Biochemistry & Molecular Biophysics

Contribution of short RNAs to regulation of gene expression through chromatin; epigenetic phenomena in C. elegans

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WAYNE A. HENDRICKSON

Hendrickson, Wayne

Email: wah2@columbia.edu
Phone: 212-305-3456                           Fax: 212-305-7379                        Location: BB-203

University Professor, Investigator, Howard Hughes Medical Institute

Structural biology of macromolecules; diffraction and computational methods

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DAVID HIRSH

Hirsh, David

Email: dih1@columbia.edu
Phone: 212-851-4845                           Fax: 212-854-1680                        Location: ICRC Rm. 805

Executive Vice President for Research,
Professor of Biochemistry & Molecular Biophysics

Molecular genetics of endocytosis in C. elegans; Role of cytokines in the mammalian inflammatory and immune responses

 

OLIVER HOBERT

Hobert, Oliver

Email: or38@columbia.edu
Phone: 212-305-0063                           Fax: 212-342-1810                        Location: HHSC Rm. 726A

Professor Biochemistry & Molecular Biophysics, Investigator, Howard Hughes Medical Institute

Genetic programs that control neural development in C. elegans

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BARRY HONIG

Honig, Barry

Email: bh6@columbia.edu
Phone: 212-851-4651                          Fax:  212-851-4650
Location: ICRC Rm. 815                             (AUDIII - 1130 St. Nicholas Avenue)

Professor of Biochemistry and Molecular Biophysics, Director, Center for Computational Biology and Bioinformatics
Investigator, Howard Hughes Medical Institute

Computational approaches, based on both biophysics and bioinformatics, to study the structure and function of biological macromolecules

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THOMAS M. JESSELL

Jessell, Thomas M.

Email: tmj1@columbia.edu
Phone: 212- 305-1531                           Fax: 212-568-8473
Location: HHSC-1013

Claire Tow Professor, Neuroscience, Biochemistry & Molecular Biophysics
Investigator, Howard Hughes Medical Institute, Co-director, Kavli Institute

Molecular mechanisms of neuronal differentiation, axon guidance, and cell recognition in vertebrate development

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ERIC R. KANDEL

Kandel, Eric R.

Email: erk5@columbia.edu
Phone: 212-305-4143                           Fax: 212-543-5474                        Location: P.I. Annex Rm. 663

University Professor, Neuroscience, Psychiatry, Physiology & Cellular Biophysics, Biochemistry & Molecular Biophysics, Investigator, Howard Hughes Medical Institute, Co-Director, Kavli Institute

Cell and molecular mechanisms of associative and non-associative learning in invertebrates and vertebrates

 

ARTHUR KARLIN

Karlin, Arthur

Email: ak12@columbia.edu
Phone: 212-305-5778                           Fax: 212-305-5594                        Location: P&S- 11th Fl. Rm. 401

Higgins Professor of Biochemistry and Molecular Biophysics and Neurology and Professor of Physiology and Cellular Biophysics; Director of Center for Molecular Recognition

Molecular mechanisms of receptor function

 

Maniatis, Tom

Chairman

Email: tm2472@columbia.edu
Phone: 212-305-3669                                
Fax: 212-305-7932                                     Location: HHSC Rm. 616

Isidore S. Edelman Professor of Biochemistry

Molecular and cellular mechanisms of gene regulation in the nervous system at the levels of signal transduction, transcription and RNA splicing.

 

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RICHARD S. MANN

Mann, Richard S.

Email: rsm10@columbia.edu
Phone: 212-305-7731                           Fax: 212-305-7924                        Location: HHSC Rm. 1104

Higgins Professor of Biochemistry & Molecular Biophysics

Control of pattern formation by homeotic genes and their downstream targets in Drosophila

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ARTHUR G. PALMER, III

Palmer, Arthur G. III                               Vice Chair

Email: agp6@columbia.edu
Phone: 212-305-8675                             Fax: 212-305- 6949                                Location: BB Rm. 504

Robert Wood Johnson Jr. Professor of Biochemistry & Molecular Biophysics

Structure, function, and dynamics of proteins, fluctuations in chemical and biological systems; and nuclear magnetic resonance and fluorescence spectroscopies

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BURKHARD ROST

Shapiro, Lawrence

Email: lawrenceshapiro@gmail.com
Phone: 212-342-6029                                 Fax: 212-342-6026                                     Location: Russ Berrie Rm. 403

Associate Professor, Columbia University, Department of Biochemistry and Molecular Biophysics and Edward S. Harkness Eye
Institute, Member of the Naomi S. Berrie Diabetes Center, Jules and Doris Stein Professor of Research to Prevent Blindness, RPB Foundation

Structural information obtained from X-ray crystallography to direct biochemical studies of biological problems, particularly involving neuronal cell adhesion and neural patterning


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Peter Sims

Sims, Peter

Email: pas2182@columbia.edu
Phone: 212-851-5369                                 Fax: 212-342-6026                                     Location: ICRC Bldg., Rm. 1002B

Assistant Professor, Columbia University,
Columbia Initiative for Systems Biology
Department of Biochemistry and Molecular Biophysics

We develop new technology for single cell analysis, focusing mainly on proteomics and transcriptomics.  By combining cutting-edge microscopy, next-generation sequencing, and microfabrication, we enable novel, unbiased measurements for investigation of heterogeneous biological systems


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Sobolevsky, Alexander

Email: as4005@columbia.edu
Phone: 212-305-4249

Fax: 212-305-7932

Location: BB Rm. 513

Assistant Professor, Columbia University, Department of Biochemistry and Molecular Biophysics Studies of ion channel structure and function using biophysical and biochemical approaches including X-ray crystallography and electrophysiology.

Tavazoie, Saeed

                                                      Tavazoie, Saeed

Email: st2744@columbia.edu
Phone: 212-851-5166                                 Fax: 212-305-7932                                    
Location: Russ Berrie-Rm. 405A

Professor of Biochemistry and Molecular Biophysics, Columbia Initiative in Systems Biology

 

Organizing principles underlying the evolution and function of molecular networks; predictive models of gene expression from sequence; elucidating regulatory perturbations in pathological states such as cancer; evolution of complex microbial behaviors; antibiotic tolerance pathways

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Chaolin Zhang

Zhang, Chaolin

Email: cz2294@columbia.edu                    
Phone: 212-305-9354

Fax: 212-342-4512

Location: P&S Bldg., Rm. 4-448

Assistant Professor, Columbia University, Columbia Initiative for Systems Biology
Department of Biochemistry and Molecular Biophysics

Development and application of novel experimental and computational approaches to studying RNA-regulatory networks in the mammalian brain and neurodegenerative diseases at the systems level.

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                                                                Zuker, Charles

Email: cz2195@columbia.edu
Phone: 212-305-7819                                 Fax: 212-342-5747                                     Location: HHSC Rm. 517A

Professor, Columbia University, Departments of Biochemistry and Molecular Biophysics & Neuroscience,

Investigator, Howard Hughes Medical Institute

 

Charles Zuker's laboratory is using a combined molecular, genetic, and physiological approach to study signal processing, information transfer, and coding mechanisms in sensory systems.

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BUILDING ABBREVIATION

P&S: College of Physicians & Surgeons
BB: William H. Black Building
HHSC: Hammer Health Sciences Center