Department of Biochemistry And Molecular Biophysics

The name of each faculty member is linked to a more detailed description of that person's research interests

Faculty Member	Affiliations	Research Interests
Axel, Richard Email: ra27@columbia.edu Phone: 212-305-6915 Fax: 212-923-7249 Location: HHSC-1014	University Professor, Biochemistry & Molecular Biophysics, Neuroscience, Pathology & Cell Biology Investigator, Howard Hughes Medical Institute	Defining the logic of olfactory perception; how individual sensory neurons express a specific receptor and how the brain distinguishes which receptors have been activated
Califano, Andrea Email: califano@c2b2.columbia.edu Phone: 212-851-5183 Fax: 212-305-9500 Location: C2B2 Rm. 912	Professor of Systems Biology in the Department of Biochemistry and Molecular Biophysics, in the Institute for Cancer Genetics, and in the Department of Biomedical Informatics. Director, Columbia Initiative in Systems Biology Director, JP Sulzberger MD Columbia Genome Center Associate Director, Herbert Irving Comprehensive Cancer Center	Dissecting and interrogating the regulatory logic of the cancer cell using a combination of high-throughput experimental and computational systems biology approaches. Identifying master regulators of stem cell pluripotency and lineage specific differentiation.
Frank, Joachim Email: jf2192@columbia.edu Phone: 212-305-9510 Fax: 212-305-9500 Location: BB 221	Professor of Biochemistry & Molecular Biophysics and Biological Sciences Investigator, Howard Hughes Medical Institute	We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction. Using these methods, and flexible fitting of X-ray structures, the dynamics of the decoding and translocation mechanisms are revealed.
Goff, Stephen P. Email: spg1@columbia.edu Phone: 212-305-3794 Fax: 212-305-5106 Location: HHSC-1310	Higgins Professor of Biochemistry and Molecular Biophysics and Professor of Microbiology Investigator, Howard Hughes Medical Institute	Retroviral replication; tyrosine kinase oncogenes
Gottesman, Max E. Email: meg8@columbia.edu Phone: 212- 305-6900 Fax: 212-305-1741 Location: HHSC-1504	Charles H. Revson Professor of Biochemistry and Molecular Biophysics and Microbiology (in the Institute of Cancer Research); Director - Institute Cancer Research	Regulation of transcription termination in /E. coli/ and bacteriophage; DNA damage repair and signal transduction in eukaryotes.
Greene, Eric C. Email: ecg2108@columbia.edu Phone: 212-342-2944 Fax: 212-305-5427 Location: BB-536	Associate Professor Biochemistry & Molecular Biophysics Investigator, Howard Hughes Medical Institute	Molecular mechanisms of DNA recombination and repair; single molecule fluorescence microscopy and other biochemical approaches.
Greenwald, Iva Email: isg4@columbia.edu Phone: 212-305-6928 Fax: 212-305-1721 Location: HHSC-720	Professor of Biochemistry & Molecular Biophysics and Genetics & Development Investigator, Howard Hughes Medical Institute	LIN-12/Notch signaling and cell-cell interactions during development.
Grishok, Alla Email: ag2691@columbia.edu Phone: 212-305-9893 Fax: 212-304-5707 Location: HHSC 611	Assistant Professor of Biochemistry & Molecular Biophysics	Contribution of short RNAs to regulation of gene expression through chromatin; epigenetic phenomena in C. elegans
Hendrickson, Wayne Email: wayne@convex.hhmi.columbia.edu Phone: 212-305-3456 Fax: 212-305-7379 Location: BB-203	University Professor Investigator, Howard Hughes Medical Institute	Structural biology of macromolecules; diffraction and computational methods
Hirsh, David Email: dih1@columbia.edu Phone: 212-851-4845 Fax: 212-854-1680 Location: ICRC Rm. 805	Executive Vice President for Research, Professor of Biochemistry & Molecular Biophysics	Molecular genetics of endocytosis in C. elegans; Role of cytokines in the mammalian inflammatory and immune responses
Hobert, Oliver Email: or38@columbia.edu Phone: 212-305-0063 Fax: 212-342-1810 Location: HHSC-726A	Professor Biochemistry & Molecular Biophysics Investigator, Howard Hughes Medical Institute	Genetic programs that control neural development in C. elegans
Honig, Barry Email: bh6@columbia.edu Phone: 212-851-4651 Fax: 212-851-4650 Location: ICRC (AUDIII - 1130 St. Nicholas Avenue) Room 815	Professor of Biochemistry and Molecular Biophysics, Director, Center for Computational Biology and Bioinformatics Investigator, Howard Hughes Medical Institute	Computational approaches, based on both biophysics and bioinformatics, to study the structure and function of biological macromolecules
Jessell, Thomas M. Email: tmj1@columbia.edu Phone: 212- 305-1531 Fax: 212-568-8473 Location: HHSC-1013	Claire Tow Professor, Neuroscience, Biochemistry & Molecular Biophysics Investigator, Howard Hughes Medical Institute Co-director, Kavli Institute	Molecular mechanisms of neuronal differentiation, axon guidance, and cell recognition in vertebrate development
Kandel, Eric R. Email: erk5@columbia.edu Phone: 212-305-4143 Fax: 212-543-5474 Location: P.I. Annex-663	University Professor, Neuroscience, Psychiatry, Physiology & Cellular Biophysics, Biochemistry & Molecular Biophysics Investigator, Howard Hughes Medical Institute Co-Director, Kavli Institute	Cell and molecular mechanisms of associative and non-associative learning in invertebrates and vertebrates
Karlin, Arthur Email: ak12@columbia.edu Phone: 212-305-5778 Fax: 212-305-5594 Location: P&S-11-401	Higgins Professor of Biochemistry and Molecular Biophysics and Neurology and Professor of Physiology and Cellular Biophysics; Director of Center for Molecular Recognition	Molecular mechanisms of receptor function
Maniatis, Tom Chairman Email: tm2472@columbia.edu Phone: 212-305-3669 Fax: 212-305-7932 Location: HHSC-616	Isidore S. Edelman Professor of Biochemistry	Molecular and cellular mechanisms of gene regulation in the nervous system at the levels of signal transduction, transcription and RNA splicing.
Mann, Richard S. Email: rsm10@columbia.edu Phone: 212-305-7731 Fax: 212-305-7924 Location: HHSC 1104	Higgins Professor of Biochemistry & Molecular Biophysics	Control of pattern formation by homeotic genes and their downstream targets in Drosophila
Palmer, Arthur G. III Vice Chair Email: agp6@columbia.edu Phone: 212-305-8675 Fax: 212-305- 6949 Location: BB Rm. 504	Robert Wood Johnson Jr. Professor of Biochemistry & Molecular Biophysics	Structure, function, and dynamics of proteins, fluctuations in chemical and biological systems; and nuclear magnetic resonance and fluorescence spectroscopies
Shapiro, Lawrence Email: lss8@columbia.edu Phone: 212-342-6029 Fax: 212-342-6026 Location: Russ Berrie Rm. 403	Associate Professor, Columbia University, Department of Biochemistry and Molecular Biophysics and Edward S. Harkness Eye Institute, Member of the Naomi S. Berrie Diabetes Center, Jules and Doris Stein Professor of Research to Prevent Blindness, RPB Foundation	Structural information obtained from X-ray crystallography to direct biochemical studies of biological problems, particularly involving neuronal cell adhesion and neural patterning
Sims, Peter Email: pas2182@columbia.edu Phone: 212-851-5369 Fax: 212-342-6026 Location: ICRC Bldg., Rm. 1002B	Assistant Professor, Columbia University, Columbia Initiative for Systems Biology Department of Biochemistry and Molecular Biophysics	We develop new technology for single cell analysis, focusing mainly on proteomics and transcriptomics. By combining cutting-edge microscopy, next-generation sequencing, and microfabrication, we enable novel, unbiased measurements for investigation of heterogeneous biological systems
Sobolevsky, Alexander Email: as4005@columbia.edu Phone: 212-305-4249 Fax: 212-305-7932 Location: BB 513	Assistant Professor, Columbia University, Department of Biochemistry and Molecular Biophysics	Studies of ion channel structure and function using biophysical and biochemical approaches including X-ray crystallography and electrophysiology.
Tavazoie, Saeed Email: st2744@columbia.edu Phone: 212-851-5166 Fax: 212-305-7932 Location: Russ Berrie-405A	Professor of Biochemistry and Molecular Biophysics Columbia Initiative in Systems Biology	Organizing principles underlying the evolution and function of molecular networks; predictive models of gene expression from sequence; elucidating regulatory perturbations in pathological states such as cancer; evolution of complex microbial behaviors; antibiotic tolerance pathways
Zuker, Charles Email: cz2195@columbia.edu Phone: 212-305-7819 Fax: 212-342-5747 Location: HHSC 517A	Professor, Columbia University, Departments of Biochemistry and Molecular Biophysics & Neuroscience, Investigator, Howard Hughes Medical Institute	Charles Zuker's laboratory is using a combined molecular, genetic, and physiological approach to study signal processing, information transfer, and coding mechanisms in sensory systems.

Faculty Member

Affiliations

Research Interests

Richard Axel

Email: ra27@columbia.edu Phone: 212-305-6915 Fax: 212-923-7249 Location: HHSC-1014

University Professor, Biochemistry & Molecular Biophysics, Neuroscience, Pathology & Cell Biology
Investigator, Howard Hughes Medical Institute

Defining the logic of olfactory perception; how individual sensory neurons express a specific receptor and how the brain distinguishes which receptors have been activated

Califano, Andrea

Email: califano@c2b2.columbia.edu Phone: 212-851-5183 Fax: 212-305-9500 Location: C2B2 Rm. 912

Professor of Systems Biology in the Department of Biochemistry and Molecular Biophysics, in the Institute for Cancer Genetics, and in the Department of Biomedical Informatics. Director, Columbia Initiative in Systems Biology Director, JP Sulzberger MD Columbia Genome Center Associate Director, Herbert Irving Comprehensive Cancer Center

Dissecting and interrogating the regulatory logic of the cancer cell using a combination of high-throughput experimental and computational systems biology approaches. Identifying master regulators of stem cell pluripotency and lineage specific differentiation.

JOACHIM FRANK

Frank, Joachim

Email: jf2192@columbia.edu
Phone: 212-305-9510 Fax: 212-305-9500
Location: BB 221

Professor of Biochemistry & Molecular Biophysics and Biological Sciences
Investigator, Howard Hughes Medical Institute

We investigate the mechanism of translation on the ribosome by using cryo-electron microscopy and single-particle reconstruction. Using these methods, and flexible fitting of X-ray structures, the dynamics of the decoding and translocation mechanisms are revealed.

STEPHEN P. GOFF

Goff, Stephen P.

Email: spg1@columbia.edu
Phone: 212-305-3794 Fax: 212-305-5106
Location: HHSC-1310

Higgins Professor of Biochemistry and Molecular Biophysics and Professor of Microbiology
Investigator, Howard Hughes Medical Institute

Retroviral replication; tyrosine kinase oncogenes

MAX E. GOTTESMAN

Gottesman, Max E.

Email: meg8@columbia.edu
Phone: 212- 305-6900 Fax: 212-305-1741 Location: HHSC-1504

Charles H. Revson Professor of Biochemistry and Molecular Biophysics and Microbiology (in the Institute of Cancer Research); Director - Institute Cancer Research

Regulation of transcription termination in /E. coli/ and bacteriophage; DNA damage repair and signal transduction in eukaryotes.

ERIC C. GREENE

Greene, Eric C.

Email: ecg2108@columbia.edu
Phone: 212-342-2944 Fax: 212-305-5427 Location: BB-536

Associate Professor Biochemistry & Molecular Biophysics
Investigator, Howard Hughes Medical Institute

Molecular mechanisms of DNA recombination and repair; single molecule fluorescence microscopy and other biochemical approaches.

IVA GREENWALD

Greenwald, Iva

Email: isg4@columbia.edu
Phone: 212-305-6928 Fax: 212-305-1721 Location: HHSC-720

Professor of Biochemistry & Molecular Biophysics and Genetics & Development
Investigator, Howard Hughes Medical Institute

LIN-12/Notch signaling and cell-cell interactions during development.

ALLA GRISHOK

Grishok, Alla

Email: ag2691@columbia.edu
Phone: 212-305-9893 Fax: 212-304-5707 Location: HHSC 611

Assistant Professor of Biochemistry & Molecular Biophysics

Contribution of short RNAs to regulation of gene expression through chromatin; epigenetic phenomena in C. elegans

WAYNE A. HENDRICKSON

Hendrickson, Wayne

Email: wayne@convex.hhmi.columbia.edu
Phone: 212-305-3456 Fax: 212-305-7379 Location: BB-203

University Professor
Investigator, Howard Hughes Medical Institute

Structural biology of macromolecules; diffraction and computational methods

DAVID HIRSH

Hirsh, David

Email: dih1@columbia.edu
Phone: 212-851-4845 Fax: 212-854-1680 Location: ICRC Rm. 805

Executive Vice President for Research,
Professor of Biochemistry & Molecular Biophysics

Molecular genetics of endocytosis in C. elegans; Role of cytokines in the mammalian inflammatory and immune responses

OLIVER HOBERT

Hobert, Oliver

Email: or38@columbia.edu
Phone: 212-305-0063 Fax: 212-342-1810 Location: HHSC-726A

Professor Biochemistry & Molecular Biophysics
Investigator, Howard Hughes Medical Institute

Genetic programs that control neural development in C. elegans

BARRY HONIG

Honig, Barry

Email: bh6@columbia.edu
Phone: 212-851-4651 Fax: 212-851-4650
Location: ICRC (AUDIII - 1130 St. Nicholas Avenue) Room 815

Professor of Biochemistry and Molecular Biophysics, Director, Center for Computational Biology and Bioinformatics
Investigator, Howard Hughes Medical Institute

Computational approaches, based on both biophysics and bioinformatics, to study the structure and function of biological macromolecules

THOMAS M. JESSELL

Jessell, Thomas M.

Email: tmj1@columbia.edu
Phone: 212- 305-1531 Fax: 212-568-8473
Location: HHSC-1013

Claire Tow Professor, Neuroscience, Biochemistry & Molecular Biophysics
Investigator, Howard Hughes Medical Institute
Co-director, Kavli Institute

Molecular mechanisms of neuronal differentiation, axon guidance, and cell recognition in vertebrate development

ERIC R. KANDEL

Kandel, Eric R.

Email: erk5@columbia.edu
Phone: 212-305-4143 Fax: 212-543-5474 Location: P.I. Annex-663

University Professor, Neuroscience, Psychiatry, Physiology & Cellular Biophysics, Biochemistry & Molecular Biophysics
Investigator, Howard Hughes Medical Institute
Co-Director, Kavli Institute

Cell and molecular mechanisms of associative and non-associative learning in invertebrates and vertebrates

ARTHUR KARLIN

Karlin, Arthur

Email: ak12@columbia.edu
Phone: 212-305-5778 Fax: 212-305-5594 Location: P&S-11-401

Higgins Professor of Biochemistry and Molecular Biophysics and Neurology and Professor of Physiology and Cellular Biophysics; Director of Center for Molecular Recognition

Molecular mechanisms of receptor function

Maniatis, Tom

Chairman

Email: tm2472@columbia.edu
Phone: 212-305-3669 Fax: 212-305-7932 Location: HHSC-616

Isidore S. Edelman Professor of Biochemistry

Molecular and cellular mechanisms of gene regulation in the nervous system at the levels of signal transduction, transcription and RNA splicing.

RICHARD S. MANN

Mann, Richard S.

Email: rsm10@columbia.edu
Phone: 212-305-7731 Fax: 212-305-7924 Location: HHSC 1104

Higgins Professor of Biochemistry & Molecular Biophysics

Control of pattern formation by homeotic genes and their downstream targets in Drosophila

ARTHUR G. PALMER, III

Palmer, Arthur G. III Vice Chair

Email: agp6@columbia.edu
Phone: 212-305-8675 Fax: 212-305- 6949 Location: BB Rm. 504

Robert Wood Johnson Jr. Professor of Biochemistry & Molecular Biophysics

Structure, function, and dynamics of proteins, fluctuations in chemical and biological systems; and nuclear magnetic resonance and fluorescence spectroscopies

BURKHARD ROST

Shapiro, Lawrence

Email: lss8@columbia.edu
Phone: 212-342-6029 Fax: 212-342-6026 Location: Russ Berrie Rm. 403

Associate Professor, Columbia University, Department of Biochemistry and Molecular Biophysics and Edward S. Harkness Eye
Institute, Member of the Naomi S. Berrie Diabetes Center,
Jules and Doris Stein Professor of Research to Prevent Blindness, RPB Foundation

Structural information obtained from X-ray crystallography to direct biochemical studies of biological problems, particularly involving neuronal cell adhesion and neural patterning

Peter Sims

Sims, Peter

Email: pas2182@columbia.edu
Phone: 212-851-5369 Fax: 212-342-6026 Location: ICRC Bldg., Rm. 1002B

Assistant Professor, Columbia University,
Columbia Initiative for Systems Biology
Department of Biochemistry and Molecular Biophysics

We develop new technology for single cell analysis, focusing mainly on proteomics and transcriptomics. By combining cutting-edge microscopy, next-generation sequencing, and microfabrication, we enable novel, unbiased measurements for investigation of heterogeneous biological systems

Sobolevsky, Alexander

Email: as4005@columbia.edu
Phone: 212-305-4249

Fax: 212-305-7932

Location: BB 513

Assistant Professor, Columbia University, Department of Biochemistry and Molecular Biophysics

Studies of ion channel structure and function using biophysical and biochemical approaches including X-ray crystallography and electrophysiology.

Tavazoie, Saeed

Tavazoie, Saeed

Email: st2744@columbia.edu
Phone: 212-851-5166 Fax: 212-305-7932
Location: Russ Berrie-405A

Professor of Biochemistry and Molecular Biophysics

Columbia Initiative in Systems Biology

Organizing principles underlying the evolution and function of molecular networks; predictive models of gene expression from sequence; elucidating regulatory perturbations in pathological states such as cancer; evolution of complex microbial behaviors; antibiotic tolerance pathways

Zuker, Charles

Email: cz2195@columbia.edu
Phone: 212-305-7819 Fax: 212-342-5747
Location: HHSC 517A

Professor, Columbia University, Departments of Biochemistry and Molecular Biophysics & Neuroscience,

Investigator, Howard Hughes Medical Institute

Charles Zuker's laboratory is using a combined molecular, genetic, and physiological approach to study signal processing, information transfer, and coding mechanisms in sensory systems.

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BUILDING ABBREVIATION

P&S: College of Physicians & Surgeons
BB: William H. Black Building
HHSC: Hammer Health Sciences Center