ERIC R. KANDEL

We combine behavioral, cellular, and molecular biological approaches to delineate the changes that underlie learning and memory in invertebrate Aplysia and in genetically modified mice. In recent years we have focused, in particular, on the switch from short- to long-term memory and on the mechanism of synapse specific modification.

Selected Publications

Goelet, P., Castellucci, V., Schacher, S. and Kandel, E.R. (1986) The long and short of long-term memory. Nature 322, 419-422.

Bartsch, D., Ghirardi, M., Skehel, P.A., Karl, K.A., Herder, S.P., Chen M., Bailey, C.H. and Kandel, E.R. (1995) Aplysia CREB2 represses long-term facilitation: Relief of repression converts transient facilitation into long-term functional and structural change. Cell 83, 979- 992.

Martin, K.C., Casadio, A., Zhu, H., Yaping, E., Rose, J., Bailey, C.H., Chen, M., and Kandel, E.R. (1998) Synapse-specific transcription-dependent long-term facilitation of the sensory to motor neuron connection in Aplysia: A function for local protein synthesis in memory storage. Cell 91:927-938.

Casadio, A., Martin, D.C., Giuststto, M., Zhu, H., Chen, M., Bartsch, D., Bailey, C.H., and Kandel, E.R. (1999) A transient neuron-wide form of CREB-mediated long-term facilitation can be stabilized at specific synapses by local protein synthesis. Cell 99:221-237.

Malleret, G., Haditsch, U., Genoux, D., Jones M.W., Bliss, T.V.P., Vanhoose, A.M., Weitlauf, C., Kandel, E.R., Winder, D.G. and Mansuy, I.M., (2001) Inducible and reversible enhancement of learning, memory and long-term potentiation by genetic inhibition of calcineurin. Cell 104:675-686.