Publications

Since 2000:

Mann, R.S. and G. Morata (2000). The developmental and molecular biology of genes that subdivide the body of Drosophila. Annual Review of Cell and Developmental Biology (invited review), 16:243-271.

Casares, F. and R.S. Mann (2000). Dual role for homothorax in inhibiting wing blade development and specifying proximal wing structures in Drosophila. Development, 127:1499-1508.

Affolter, M. and R.S.. Mann (2001). Development: legs, eyes, or wings – selectors and signals make the difference. Science (Perspective), 292:1080-1081.

Casares, F. and R.S. Mann (2001). The ground state of the ventral appendage in Drosophila. Science, 293:1477-1480.

Mann R.S. and F. Casares (2002) Developmental biology: Signalling legacies. Nature 418:737-739.

Mann, R.S. and S.B. Carroll (2002) Molecular mechanisms of selector gene function and evolution. Curr. Op. Genet. Dev. 12:592-600.

Bessa J, Gebelein B, Pichaud F, Casares F, Mann RS. Combinatorial control of Drosophila eye development by eyeless, homothorax, and teashirt. Genes Dev. 2002 Sep 15;16(18):2415-27.

Gebelein B, Culi J, Ryoo HD, Zhang W, Mann RS. (2002) Specificity of Distalless repression and limb primordia development by abdominal Hox proteins. Dev Cell. 3:487-98.

Wang Z, Mann RS. (2003) Requirement for two nearly identical TGIF-related homeobox genes in Drosophila spermatogenesis. Development 130:2853-65.

Culi J, Mann RS. (2003) Boca, an endoplasmic reticulum protein required for wingless signaling and trafficking of LDL receptor family members in Drosophila. Cell. 112:343-54.

Kobayashi M, Fujioka M, Tolkunova EN, Deka D, Abu-Shaar M, Mann RS, JaynesJB. (2003) Engrailed cooperates with extradenticle and homothorax to repress target genes in Drosophila. Development. 130:741-51

Sosinsky A, Bonin CP, Mann RS, Honig B. (2003) Target Explorer: An automated tool for the identification of new target genes for a specified set of transcription factors. Nucleic Acids Res. 31:3589-92.

Mann RS. (2004) Two Pax are better than one. Nat Genet. Jan;36(1):10-1.

Bonin CP, Mann RS. (2004) A piggyBac transposon gene trap for the analysis of gene expression and function in Drosophila. Genetics. 167(4):1801-11.

Culi J., Springer TA, and Mann RS (2004) Boca-dependent maturation of beta-propeller/EGF modules in low-density lipoprotein receptor proteins. EMBO J. Mar 24;23(6):1372-80.

Gebelein B, McKay DJ, and Mann RS (2004) Direct integration of Hox and segmentation gene inputs during Drosophila development. Nature (Article) Oct 7;431(7009):653-9.

Zirin JD and Mann RS (2004) Differing strategies for the establishment and maintenance of teashirt and homothorax repression in the Drosophila wing. Development. Nov;131(22):5683-93.

Wildonger, J. and Mann RS (2005) The t(8:21) translocation converts AML1 into a constitutive transcriptional repressor. Development. 132(10):2263-72.

Mann RS and Culi J. (2005) Developmental biology: morphogens hitch a greasy ride. Nature. May 5;435(7038):30-3.

Wildonger J, Sosinsky A, Honig B, and Mann RS. (2005) Lozenge directly activates argos and klumpfuss to regulate programmed cell death. Genes Dev. May 1;19(9):1034-9.

Ice RJ, Wildonger J, Mann RS, and Hiebert SW. (2005) Comment on "Nervy links protein kinase A to plexin-mediated semaphorin repulsion". Science. 2005 Jul 22;309(5734):558; & Supporting online supplementary data.

Culi, J., Aroca P., Modolell, J. and Mann RS (2006)jing is required for wing development and to establish the proximo-distal axis of the leg in Drosophila melanogaster. Genetics. 2006 May;173(1):255-66.

Crickmore, M. and Mann, RS. (2006) Hox control of organ size by regulation of morphogen production and mobility. Science (Article). 2006 Jul 7;313(5783):63-8.

Noro, B., Culi, J., McKay, DJ, Zhang, W., and Mann RS (2006) Distinct functions of homeodomain-containing and homeodomain-less isoforms encoded by homothorax. Genes Dev. 2006 Jun 15;20(12):1636-50

Crickmore, M. and Mann, RS.(2007) Hox control of morphogen mobility and organ development through regulation of glypican expression. Development, 2007 Jan;134(2):327-34

Stevens, KE and Mann, RS. (2007) A balance between two nuclear localization sequences and a nuclear export sequence governs extradenticle subcellular localization. Genetics. 2007 Apr;175(4):1625-36

Zirin, JD and Mann, RS. (2007) Nubbin and Teashirt mark barriers to clonal growth along the proximal-distal axis of the Drosophila wing. Dev Biol. 2007 Apr 15;304(2):745-58.

Sosinsky, A, Honig, B., Mann, RS, and Califano, A. (2007) Discovering transcriptional regulatory regions in Drosophila by a nonalignment method for phylogenetic footprinting. Proc Natl Acad Sci U S A. 2007 Apr 10;104(15):6305-10

Gebelein, B. and Mann, RS. (2007) Compartmental modulation of abdominal Hox expression by engrailed and sloppy-paired patterns the fly ectoderm. Dev Biol. 2007 May 24

Joshi, R. Passner, J., Rohs, R., Jain, R. Sosinsky, A., Crickmore, M.A., Jacob, V., Aggarwal, A.K., Honig, B. and Mann, RS. Functional specificity of a Hox protein mediated by the recognition of minor groove structure. Cell. (2007) 131(3):530-43.

Estella, C., McKay, D., and Mann, R.S. Direct integrations of Wingless, Decapentaplegic, and autoregulatory inputs into Distalless during Drosophila leg development. Dev. Cell, (2008) 14(1):86-96.

Estella, C. and Mann, R.S. Logic of Wg and Dpp induction of distal and medial fates in the Drosophila leg. Development, 2008, 135(4):627-636..

Representative publications prior to 2000:

Chan, S.-K. and R. S. Mann. (1993) The segment identity functions of Ultrabithorax are contained within its homeo domain and carboxy-terminal sequences. Genes & Development 7, 796-811.

Chan, S.-K., L. Jaffe, M. Capovilla, J. Botas, and R. S. Mann. (1994) The DNA Binding Specificity of Ultrabithorax is Modulated by Cooperative Interactions with Extradenticle, Another Homeoprotein. Cell 78, 603-615.

Mann, R.S.. (1994) engrailed-mediated repression of Ultrabithorax is necessary for the parasegment 6 identity in Drosophila. Development, 120, 3205-3212.

Feinstein, P., K. Kornfeld, D. Hogness, and R. S. Mann. (1995) Identification of Homeotic Target Genes in Drosophila melanogaster Including nervy, a Proto-Oncogene Homologue. Genetics 140, 573-586.

Pöpperl, H., M. Bienz, M. Studer, S.-K. Chan, S. Aparicio, S. Brenner, R.S. Mann and R. Krumlauf. (1995) Segmental Expression of Hoxb-1 Is Controlled by a Highly Conserved Autoregulatory Loop Dependent upon exd/pbx. Cell 81, 1031-1042.

Mann, R.S. (1995) The specificity of homeotic gene function. BioEssays 17, 855-863.

Chan, S.-K., H. Pöpperl, R. Krumlauf and R.S. Mann. (1996) An extradenticle-induced conformational change in a HOX protein overcomes an inhibitory function of the conserved hexapeptide motif. EMBO J. 15, 2476-2487.

Mann, R.S. and S.-K. Chan. (1996) Extra specificity from extradenticle: The partnership between HOX and PBX/EXD homeodomain proteins. (invited review) Trends Genet. 12, 25262.

Chan, S.-K. and R.S. Mann. (1996) A structural model of an Extradenticle-HOX-DNA complex accounts for the choice of HOX protein in the heterodimer. Proc. Natl. Acad. Sci. USA. 93, 5223-5228.

Mann, R.S. (1996) Flies in Crete: a report on the 10th annual EMBO Workshop on the Molecular and Developmental Biology of Drosophila. Trends Genet. 12, 427-428..

Mann, R.S. and M. Abu-Shaar. (1996) Nuclear import of the homeobox protein extradenticle induced by wg and dpp signaling. Nature, 383, 630-633.

Chan, S.-K., H.-D. Ryoo, A. Gould, R. Krumlauf, and R.S. Mann. (1997) Switching the in vivo specificity of a minimal HOX-responsive element. Development, 124,2007-2014.

Jaffe, L., H.-D. Ryoo, and R.S. Mann. (1997) A role for phosphorylation by casein kinase II in modulating Antennapedia function in Drosophila. Genes Dev., 11, 1327-1340.

Maconochie, M. K., S. Nonchev, H. Pöpperl, M.H. Sham, S.-K. Chan, R.S. Mann and R. Krumlauf. (1997) Cross-regulation in the mouse HoxB complex: Hoxb-1 regulates the expression of Hoxb-2 in rhombomere 4. Genes Dev. 11, 1885-1895.

Mann, R.S. (1997) Why are Hox genes clustered? BioEssays 19, 661-664.

Rieckhof, G., F. Casares, H.D. Ryoo, M. Abu-Shaar and R.S. Mann. (1997) Nuclear localization of Extradenticle requires homothorax, which encodes an Extradenticle-related homeodomain protein. Cell 91, 171-183.

Grieder, N., T. Marty, H.-D. Ryoo, R.S. Mann, and M. Affolter (1997) Synergistic activation of a Drosophila enhancer by HOM/EXD and DPP signaling. EMBO J., 16, 7402-7410.

Casares, F. and R.S. Mann (1998) Control of antennal versus leg development in Drosophila. Nature, 392, 723-726.

Gonzalez-Crespo, S., M. Abu-Shaar, M. Torres, C. Martínez-A, R. S. Mann and Ginés Morata (1998) Antagonistic interactions between extradenticle function and Hedgehog signalling in the developing limb. Nature, 394, 196-200.

Abu-Shaar, M. and R. S. Mann (1998) Generation of multiple antagonistic domains along the proximo-distal axis during Drosophila leg development. Development, 125, 3821-3830.

Passner, J., H.D. Ryoo, L. Shen, R.S. Mann, and A. Aggarwal (1999) Structure of a DNA-bound Ultrabithorax-Extradenticle homeodomain complex. Nature, 397:714-719.

Abu-Shaar, M., H.D. Ryoo, and R.S. Mann (1999) Control of the nuclear localization of Extradenticle by competing nuclear localization and export signals. Genes Dev., 13: 935-945.

Ryoo, H.D. and R.S.Mann (1999) The control of trunk Hox specificity and activity by Extradenticle. Genes Dev., 13:1704-1716.

Ryoo, H.D., Marty, T., Affolter, M., and R.S. Mann (1999) Control of Hox target genes by a DNA bound Hox/Extradenticle/Homothorax complex. Development, 126:5137-48.