Richard Axel's lab is characterizing how individual olfactory neurons choose to express only one among thousands of odorant receptor genes. Steve Goff is exploring the molecular behavior of viral oncogenes and their role in signal transduction. Alla Grishok's lab studies short RNAs to regulation of gene expression through chromatin; epigenetic phenomena in C. elegans. Richard Mann’s lab studies post-transcriptional mechanisms that control activity and specificity of homeodomain-containing transcription factors. Max Gottesman's lab studies the control of transcription termination in bacteriophage by RNA binding proteins as well as the control of gene expression in thyroid cells.
Visualizing the olfactory sensory map: Neurons involved in smell (olfaction) have been genetically altered to express a protein that can stain them blue. From Mombaert and Axel et al. (1996) Cell, 87, 675-686.
A blastoderm embryo stained with antibodies that bind to the genes hunchback and extradenticle. From Mann, R. (1996) Nature, 383, p. 630.
A high magnification view of part of a leg imaginal disc in which an activated form of the Dpp receptor Tkv was expressed in clones, stained for Exd (green), Hth (blue), and CD2 (red). See Abu-Shaar and Mann (1998) Development 125, 3821-3830.
Goff, S.P., Moloney murine leukemia virus released from infected cells
Max Gottesman's Lab Studies the Regulation of transcription termination in E. coli and bacteriophage; DNA damage repair and signal transduction in eukaryotes.
Grishok, A., and Sharp, P.A. Negative regulation of nuclear divisions in Caenorhabditis elegans by retinoblastoma and RNA interference-related genes. PNAS 102, 17360-17365 (2005).