ACADEMIC TITLE:
Chief, Division of Infectious Diseases
Harold C. Neu Professor of Medicine
Professor of Epidemiology
EDUCATION:
Columbia College, BA, 1968
Columbia University College of Physicians and Surgeons, MD, 1972
SPECIALTY: HIV pathogenesis, therapy, and vaccine development
RESEARCH SUMMARY:
Dr Scott Hammer is the Harold
C. Neu Professor of Medicine, professor of epidemiology, and chief of the
Division of Infectious Diseases at the Columbia University Medical
Center. He is also the program director for the Infectious Disease
Fellowship at Columbia University Medical Center. His career has been
devoted to improving the treatment of HIV infection. He has been an
active investigator in the Adult AIDS Clinical Trials Group (AACTG)
sponsored by the National Institute of Health (NIH). In the 1990s, he
chaired the two largest antiretroviral trials of the AACTG, ACTG 175 and
ACTG 320, which helped advance combination therapy as the standard of
care worldwide. Dr Hammer is also an investigator in the NIH-sponsored
HIV Vaccine Trials Network (HVTN), a multicenter organization whose
mission is to develop an effective preventive HIV vaccine. He is the
Protocol Chair for the Partnership for AIDS Vaccine Evaluation (PAVE)
100, a phase IIb clinical trial to evaluate the efficacy, safety, and
immunogenicity of a multiclade HIV-1 DNA plasmid vaccine followed by a
multiclade recombinant adenoviral vector vaccine in HIV-uninfected
persons. He currently is a member of the executive committee of the
AACTG and is chair of the phase I/II committee of the HVTN. He has served
as an adviser to the Swiss HIV Cohort Study, the French Agence Nationale
de Recherches sur le SIDA (ANRS), and the HIV
Netherlands–Australia–Thailand (NAT) Research Collaborative. He is vice
chair of the IAS–USA Antiretroviral Guidelines Panel and editor in chief
of the World Health Organization's (WHO) Antiretroviral Guidelines for Resource Limited
Settings. He also serves as a member of the governing council
of the International AIDS Society.
SELECTED PUBLICATIONS:
Hammer
SM, Katzenstein DA, Hughes MD, Gundacker H, Schooley RT, Haubrich RH,
Henry WK, Lederman MM, Phair JP, Niu M, Hirsch MS, Merigan TC (for the
ACTG 175 study team). A trial of nucleoside monotherapy vs. combination
therapy in HIV-infected adults with CD4 cell counts between 200 and 500
per cubic millimeter: NIAID-sponsored AIDS clinical trials group study
175. N Engl J Med.
1996;335:1081-1096.
Hammer SM, Squires KE, Hughes MD, Grimes JM, Demeter LM, Currier JS, Eron
JJ, Feinberg JE, Balfour HH, Deyton LR, Chodakewitz JA, Fischl MA (for
the AIDS clinical trials group 320 study team). A controlled trial of two
nucleoside analogues plus indinavir in persons with human
immunodeficiency virus infection and CD4 cell counts of 200 per cubic
millimeter or less. N
Engl J Med. 1997;337:725-733.
Hogan CM, Hammer SM. Host determinants in HIV infection and disease. Part
1: Cellular and humoral immune responses. Ann Intern Med. 2001;134:761-776.
Hogan CM, Hammer SM. Host determinants in HIV infection and disease. Part
2: Genetic factors and implications for antiretroviral therapeutics. Ann Intern Med.
2001;134:978-996.
Hammer SM. Increasing choices for HIV therapy. N Engl J Med.
2002;346:2022-2023.
Hammer S, Gibb D, Havlir D, Mofenson L, VAn Beek I, Vella S, Vareldzis B,
Perriens J and the WHO Writing Committee: Scaling up antiretroviral
therapy in resource-limited settings: guidelines for a public health
approach. World
Health Organization, April 2002, available at www.who.int.
Hammer
SM, Vaida F, Bennett KK, Holohan MK, Sheiner L, Eron JJ, Wheat LJ, Mitsuyasu
RT, Gulick RM, Valentine FT, Aberg JA, Rogers MD, Karol CN, Saah AJ,
Lewis RH, Bessen LJ, Brosgart C, DeGruttola V, and Mellors JW (for the
AIDS clinical trials group 398 study team). Dual vs. single protease
inhibitor therapy following antiretroviral treatment failure: A
randomized trial. J
Am Med Assoc. 2002;288:169-180.
Hammer SM, Bassett R, Squires KE, Fischl M, Demeter LM, Currier JS,
Mellors JW, Morse GD, Eron JJ, Santana JL, and DeGruttola V. A randomized
trial of nelfinavir and abacavir in combination with efavirenz and
adefovir dipivoxil in HIV-1-infected persons with virological failure
receiving indinavir. Antivir
Ther. 2003;8:507-518.
Hammer SM,
Mofenson L, Havlir D, Vitorio M, Perriens J and the WHO Writing
Committee: Scaling up antiretroviral therapy in resource-limited
settings: treatment guidelines for a public health approach, 2003
version. World
Health Organization, December 2003, available at www.who.int.
Hammer SM. Clinical practice. Management of newly diagnosed HIV
infection. N Engl J
Med. 2005;353:1702-1710.
Sobieszczyk ME, Jones J, Wilkin T, Hammer SM. Advances in antiretroviral
therapy. Top HIV Med.
2006;14:36-62.
Katzenstein DA, Richman DD, Vella S,
Yeni PG, Volberding PA; International AIDS Society--USA Panel. Treatment
for adult HIV infection: 2006 recommendations of the International AIDS
Society--USA panel. JAMA
2006;296:827-43.
B, Hammer SM, Kuritzkes DR; A5118
Team. Amdoxovir versus placebo with enfuvirtide plus optimized background
therapy for HIV-1-infected subjects failing current therapy (AACTG
A5118). Antivir Ther.
2006;11:619-23.
Katzenstein
DA, Richman DD, Vella S, Yeni PG, Volberding PA; International AIDS
Society--USA Panel. Treatment for adult HIV infection: 2006
recommendations of the International AIDS Society--USA panel. Top HIV Med.
2006;14:827-43.
Hammer S,
Riley A, Calmy A, Harries A, Duncombe C, Havlir D, Katabira E, Scano F,
Malkin JE, Lange J, Mukerjee J, Currier J, Mofenson L, Harrington M,
Schechter M, Kumarasamy N, Sow PS, Munderi P, Ojoo S, Cahn P, Phanuphak
P, Eholie S, El Sadr W, Rodriguez W: Antiretroviral therapy for HIV
infection in adults and adolescents: recommendations for a public health
approach 2006 revision. World Health Organization, August 2006, available
at www.who.int.
Taylor BS, Sobieszczyk ME,
McCutchan FE and Hammer SM: The challenge of HIV-1 subtype
diversity. NEJM
2008;358:1590-1602.
Hirsch MS, Gunthard HF, Schapiro JM, Brun-Vezinet F,
Clotet B, Hammer SM, Johnson VA, Kuritzkes DR, Mellors JW, Pillay D, Yeni
PG, Jacobsen DM and Richman DD: Antiretroviral drug resistance testing in
adult HIV-1 infection: 2008 recommendations of an International AIDS
Society - USA Panel. Clin Infect Dis 2008;47:266-285
Hammer SM, Eron JJ, Reiss P, Schooley RT, Thompson MA,
Walmsley S, Cahn P, Fischl MA, Gatell JM, Hirsch MS, Jacobsen DM,
Montaner JSG, Richman DD, Yeni PG and Volberding PA: Antiretroviral
treatment of adult HIV infection: 2008 recommendations of the
International AIDS Society – USA Panel. JAMA 2008; 300:555-570.
Demeter
LM, DeGruttola V, Lustgarten S, Bettendorf D, Fischl M, Eshleman S,
Spreen W, Nguyen BY, Koval CE, Eron JJ, Hammer S and Squires K:
Association of efavirenz hypersusceptibility with virologic response in
ACTG 368, a randomized trial of abacavir (ABC) in combination with
efavirenz (EFV) and indinavir (IDV) in HIV-infected subjects with prior
nucleoside analog experience. HIV
Clin Trials 2008;9:11-25
OFFICE INFORMATION:
Department of Medicine
Division of Infectious Diseases
630 West 168th Street, Box 82
New York, NY 10032
Tel: (212) 305-7185
Fax: (212) 305-7290
E-mail: smh48@columbia.edu
ACADEMIC TITLE:
Assistant Clinical Professor of Medicine
EDUCATION:
Yale University, BA, 1973
Columbia University College of Physicians and Surgeons, MD, 1980
SPECIALTY: HIV pathogenesis, therapy, and vaccine development
RESEARCH SUMMARY:
Dr Brudney is the director of the Infectious Disease/AIDS Clinic and the
director of TB service at NewYork–Presbyterian Hospital. She is also the
program director for the Treatment Adherence Demonstration Project. In
order to improve antiretroviral adherence in difficult populations, an
interdisciplinary program called Jumpstart was initiated in 1998 in the
Infectious Disease/AIDS Clinic at NewYork–Presbyterian Hospital. Results
from this successful program are currently being analyzed. Dr Brudney is
also the recipient of a Fogarty Award for AIDS International Training and
Research to deliver HIV treatment and study the epidemiology of sexually
transmitted diseases in Santo Domingo, Dominican Republic.
SELECTED PUBLICATIONS:
Brudney K, Dobkin JF. Resurgent tuberculosis in New York City: HIV
homelessness and the decline of TB control programs. Am Rev Respir
Dis. 1991;144:745-749.
Brudney K, Dobkin JF. A tale of two cities: TB control in Nicaragua and
New York. Sem Resp Inf. 1991;6:261-272.
Brudney K. Homelessness and tuberculosis: A study in failure. J Law
Med Eth. 1993;23:360-367.
Frieden TR et al. A multi-institutional outbreak of highly drug-resistant
tuberculosis: Epidemiology and clinical outcomes. JAMA.
1996;276:1229-1235.
Sackoff J et al. Purified protein derivative testing and tuberculosis
preventive therapy for HIV-infected patients in NYC. AIDS.
1998;12:2017-2023.
Ellerbock TV et al. Incidence of cervical squamous intraepithelial
lesions in HIV-infected women. JAMA. 2000;283:1031-1037.
Wilkin TJ, Palmer S, Brudney KF, Chiasson MA, Wright TC. Anal
intraepithelial neoplasia in heterosexual and homosexual HIV-positive men
with access to anti-retroviral therapy. J Infect Dis.
2004;190:1685-1691.
Yin M, Dobkin JF, Brudney KF, Becker C, Zadel JL, Manandhar M, Addesso-Dodd
V, Shane E. Bone mass and mineral metabolism in HIV-infected
postmenopausal women. Osteoporos Int. 2005;16:1345-1352.
Furuya EY,
Paez A, Srinivasan A, Cooksey R, Augunbraun M, Baron M, Brudney K,
Della-Latta P, Concepcion E, Fischer S, Flood M, Kellner P, Roman C,
Yakrus M, Weiss D, Granowitz EV. “Outbreak of Mycobacterium abscessus wound
infections among ‘Lipotourists’ from the United States who underwent
abdominoplasty in the Dominican Republic.” Clinical Infectious Diseases
46:1181-8; 2008.
OFFICE INFORMATION:
Harkness Pavilion, 6th Floor
180 Fort Washington Avenue
New York, NY 10032
Tel: 212-305-7068
Fax: 212-305-7692
E-mail: Kfb2@columbia.edu
ACADEMIC TITLE:
Associate Professor of Clinical Epidemiology (in Medicine)
EDUCATION:
Bennington College, BA, 1972
New York University, MS, 1978
Columbia University Mailman School of Public Health, MPH, 1985
Columbia University Mailman School of Public Health, DrPH, 1988
SPECIALTY: Epidemiology
of HIV, HPV, and other STIs; reproductive health
RESEARCH SUMMARY:
Dr Mary Ann Chiasson is an epidemiologist with a part-time faculty
appointment in the Division of Infectious Diseases. Her primary
appointment is in the Epidemiology Division at Columbia's Mailman School
of Public Health where she directed the Epidemiology of HIV/AIDS course
from 1989 through 2003. Dr Chiasson has been the vice president for
research and evaluation at Public Health Solutions since 1999. Before
joining Public Health Solutions, she served for nine years as an
assistant commissioner of health at the New York City Department of
Health with scientific and administrative responsibility for AIDS
surveillance, HIV/AIDS research and vital statistics, and epidemiology.
Dr Chiasson's research interests include the epidemiology of HIV
(particularly risk factors for sexual transmission and gynecologic
manifestations of HIV), women's reproductive health, and infant
mortality. Her current research focuses on the role of the Internet in
increasing high risk sexual behavior among men who have sex with men. The
online HIV prevention videos produced by the research collaboration she
leads can be viewed at http://www.hivbigdeal.org/.
SELECTED
PUBLICATIONS:
Sun X-W, Kuhn L, Ellerbrock TV, Chiasson MA, Bush TJ, Wright TC. Human
papillomavirus infection in women infected with the human
immunodeficiency virus. N
Engl J Med. 1997;337:1343-1349.
Chiasson MA, Berenson L, Li W, Schwartz S, Singh T, Forlenza S, Mojica BA
Hamburg MA. Declining HIV/AIDS mortality in New York City. JAIDS.1999;21:59-64.
Ellerbrock TV, Chiasson MA, Bush TJ, Sun X-W, Sawo D, Brudney K, Wright
TC. Incidence of cervical squamous intraepithelial lesions in
HIV-infected women. JAMA.
2000;283:1031-1037.
Chiasson MA,
Parsons JT, Tesoriero JM, Carballo-Dieguez A, Hirshfield S, Remien RH.
HIV behavioral research online. J Urban Health 2006; 83:73-85.
Aidala AA, Lee G, Garbers S, Chiasson MA. Sexual behavior and sexual risk
in a prospective cohort of HIV-positive men and women in New York City,
1994-2002: Implications for prevention. AIDS Educ Prev 2006; 18:12-32.
Chiasson MA,
Hirshfield S, Remien RH, Humberstone M, Wong T, Wolitski RJ. A comparison
of online and offline sexual risk in men who have sex with men: An
event-based online survey 2006. JAIDS in press.
OFFICE
INFORMATION:
Public
Health Solutions
220 Church Street, 5th floor
New York, NY 10013
Tel: 646-619-6411
Fax: 646-619-6777
ACADEMIC TITLE: Director, Clinical Microbiology Service
Professor of Clinical Pathology in Medicine
EDUCATION:
St. John’s University, MSc,
New York University, PhD, 1978
SPECIALTY: Developing and incorporating rapid laboratory assays, focusing on molecular technology to detect, characterize and study microbial pathogens causing hospital-associated and community-associated infections.
RESEARCH SUMMARY:
Dr Phyllis Della-Latta is Professor of Clinical Pathology in Medicine and Director of the Clinical Microbiology Service at the Columbia University Medical Center, NYPH. She is the recipient of the Distinguished Achievements in Clinical Microbiology Award given by the American Society for Microbiology, NYC branch and is a fellow of the American Academy of Microbiology. Her current activities include USA editor-in-chief of the Reviews in Medical Microbiology and reviewer of several national and international scientific journals. Dr. Della-Latta has served as Chair of the Advisory Committee to the Commissioner of Health on emerging pathogens and bioterrorism and is a member of the medical devices advisory committee of the Food and Drug Administration. Her appointments in professional societies include President and both fundraising and program chair of the American Society of Microbiology, NYC branch. She was a former chair of the Microbiology section of the New York Academy of Sciences and served on the NYAS presidential advisory council.
SELECTED PUBLICATIONS:
Della-Latta P and Jonas V. Inhibitory effect of Alpha-Tec XPR-Plus phosphate buffer on the enhanced Gen-Probe Amplified Mycobacterium Tuberculosis Direct Test. J Clin Microbiol 37:1234-1235, 1999.
Della-Latta P. The Mycobacteriology Milestones: Journeying to the New Millennium.
Laboratory Medicine 30:408-417, 1999.
Catanzaro, A, Perry S, Clarridge JE, Dunbar S and Della-Latta P. The role of clinical suspicion in evaluating a new diagnostic test or active tuberculosis: results of a multi-center prospective trial. JAMA 283:639-645, 2000.
Wu F and Della-Latta P. Molecular Typing Strategies. Review in Seminars in Perinatology 26 (5): pp. 357-366, 2002.
Jones RN, Della-Latta P, Lee L and Biedenbach DJ. Linezolid-Resistant Enterococcus faecium isolated from a patient without prior exposure to an oxazolidinone: Report from the SENTRY Antimicrobial Surveillance Program Diag Micro & Infect Dis 42:137-139, 2002.
Morel A-S, Wu F, Della-Latta P, Cronquist A, Rubenstein D and Saiman L. Nosocomial transmission of methicillin-resistant Staphylococcus aureus from a mother to her preterm quadruplet infants. Am J Infect Control 30:170-173, 2002.
Libre PE, Chin N-X and Della-Latta P. Intracameral antibiotics for endophthalmitis prophylaxis: A pharmacokinetic model. J. Cataract & Refractive Surgery 29:1791-1794, 2003
Larson EL, Lin SX, Gomez-Pichardo C and Della-Latta P. Effect of antibacterial home cleaning and handwashing products on infectious disease symptoms: a randomized, double-blind trial. Ann Intern Med 140:321-329, 2004.
Gupta A., Della-Latta P, Todd B, San Gabriel B, Haas J, Wu F, Rubenstein D and Saiman L. Outbreak of extended-spectrum b-lactamase-producing Klebsiella pneumoniae in a neonatal intensive care unit linked to artificial nails. Infect Control Hosp Epidemiol 25:210-215, 2004.
Sobieszczyk ME, Furuya EY, Hay CM, Pancholi P, Della-Latta P, Hammer SM, Kubin CJ. Combination therapy with polymyxin B for the treatment of multidrug-resistant gram-negative respiratory tract infections. J Antimicrob Chemotherapy 54:566-9, 2004.
Della-Latta P,Mycobacteriology (Section Editor). In Essential Procedures for Clinical Microbiology. Chapter 7. 2nd ed. H.J. Isenberg (editor-in-chief). American Society for Microbiology, Washington DC, 2004.
Weiner RS, Della-Latta P and Schluger NW. Effect of nucleic acid amplification for Mycobacterium tuberculosis on clinical decision making in suspected extrapulmonary tuberculosis. Chest 128:102-107, 2005.
Pancholi P, Healy M, Bittner T, Webb R, Wu F, Aiello A, Larson E and Della-Latta P. Molecular characterization of hand flora and environmental isolates in a community setting. J. Clin. Microbiol. 43:5202-5207, 2005.
Wu F and Della-Latta P. Pulsed- Field Gel Electrophoresis (PFGE). InAdvanced Techniques in Diagnostic Microbiology, Part I, Chapter 9, pp. 143-157. Eds.Yi-Wei Tang and C.W. Stratton. Springer Science + Business Media, LLC, 2006.
Alberte-Castineiras, A, Brezmes-Valivieso MG, Campos-Bueno A, Montes-Martinez I, Lopez-Medrano R, Avellaneda C, Perez-Pascual P and Della-Latta P. Drug-resistant tuberculosis in Castilla-Leon, Spain, 1996-2000. Int J Tuberc Lung Dis 10:554-558, 2006.
Graham PL, Della-Latta P, Wu F, Zhou J and Saiman L. The gastrointestinal tract serves as the reservoir for gram-negative pathogens in very low birth weight infants. Ped Infect Dis 26:1153-1155, 2007.
Chen KT, Campbell H, Borrell LN, Huard RC, Saiman L and Della-Latta P. Predictors and outcomes for pregnant women with vaginal-rectal carriage of community-associated methicillin-resistant Staphylococcusaureus. Am J. Perinatol 24:235-240, 2007.
Cook HA, Cimiotti JP, Della-Latta P, Saiman L and Larson EL. Antimicrobial resistance patterns of colonizing flora on nurses’ hands in the neonatal intensive care unit. Amer J. Infect Control 35:231-236, 2007.
Furuya EY, Cook HA, Lee M-H, Miller M, Larson E, Hyman S, Della-Latta P, Mendonca E and Lowy F. Community-associated methicillin-resistant Staphylococcus aureus prevalence: How common is it? A methodological comparison of prevalence ascertainment. Amer J. Infect Control 35:359-366, 2007.
Della-Latta P. Nucleic Acid Amplification Tests (NAATs) for Direct Detection of M. tuberculosis Complex in Clinical Specimens; Approved Guideline, In Clinical and Laboratory Standards Institute (CLSI, formerly NCCLS), Chapter 7.2, Volume 28, M48-A, Wayne, PA, 2008.
Schlaberg R, Huard RC and Della-Latta P. Nocardia cyriacigeorgica, an emerging pathogen in the United States. J. Clin. Micro 46:265-273, 2008.
Bodle ED, Cunningham JA, Della-Latta P, Schluger NW and Saiman L. Epidemiology of nontuberculous mycobacteria in patients without HIV infection, New York City. Emer Infect Dis 14:390-396, 2008.
Furuya EY, Paez A, Srinivasan A, Cooksey R, Augenbraun M, Baron M, Brudney K, Della-Latta P, Estivariz C, Fischer S, Flood M, Kellner P, Roman C, Yakrus M, Weiss D and Granowitz E. Outbreak of Mycobacterium abscessus wound infections among “lipotourists” from the United States who underwent abdominoplasty in the Dominican Republic. Clin Infect Dis 46:1181-1188, 2008.
Shepard JR, Addison RM, Alexander BD, Della-Latta P, Gherna M, Haase G, Hall G, Johnson JK, Merz WG, Peltroche-Llacsahuanga H, Stender H, Venezia RA, Wilson D, Procop GW, Wu F and. Fiandaca MJ. Multicenter evaluation of the Candida albicans/Candida glabrata peptide nucleic acid fluorescent in situ hybridization methods for simultaneous dual-color identification of C.albicans and C.glabrata directly from blood culture bottles J. Clin Micro 46:50-55, 2008.
Reich-Slotsky R., Wu F, Della-Latta P, Savage DG and Schwartz J. Application of pulsed-field electrophoresis to dienify the source of bacterial contamination of peripheral blood progenitor cell products. Transfusion 48:2409-2423, 2008.
OFFICE INFORMATION:
Department of Pathology
Clinical Microbiology Service, CHC 3-325
622 West 168th Street
New York, NY 10032
Tel: (212) 305-2929
Fax: (212) 305-8971
E-mail: pd23@columbia.edu
ACADEMIC TITLE:
Arnold P. Gold Foundation Associate Professor of Clinical Medicine
EDUCATION:
Columbia College, BA, 1968
Dartmouth Medical School, BMS, 1970
Harvard Medical School, MD, 1972
SPECIALTY: Antiretroviral therapy, harm reduction
RESEARCH SUMMARY:
Dr Jay Dobkin is the Arnold P. Gold Foundation Associate Professor of
Clinical Medicine. Dr Dobkin is the director of the AIDS program at
Columbia University Medical Center. He is the principal investigator of
an ongoing series of quantitative assessments of interventions to promote
improved adherence to antiretroviral therapy. Dr Dobkin is also
developing assessment strategies for antiretroviral treatment programs
targeting injection drug users in the former Soviet Union in
collaboration with several nongovernmental organizations active in these
areas including the Open Society Institute (New York) and the Open Health
Institute (Moscow). He serves as a consultant to the World Health
Organization on care and treatment of HIV-infected injection drug users.
He is involved in research examining the pathogenesis of HIV-associated
bone loss in a longitudinal cohort of postmenopausal women. Dr Dobkin is
also the principal investigator of several industry-sponsored studies of
new antiretroviral agents.
SELECTED PUBLICATIONS:
Cohn D, Dobkin JF. Treatment and prevention of tuberculosis in HIV
infection. AIDS. 1993;7(suppl 1):S195-S202.
Brunswick A et al. HIV-1 seroprevalence and risk behaviors in an urban
African American community cohort. Am J Public Health.
1993;83:1390-1394.
Gormam JM et al. Development and characteristics of a medical staging
system for HIV infection. Int J Methods Psychiatr Res.
1993;2:117-124.
Thomas C, Dobkin JF, Weinberger O. TAT-medicated transcellular activation
of HIV-1 long terminal repeat directed gene expression by HIV-1 infected
peripheral blood mononuclear cells. J Immunology.
1994;153:3831-3839.
Lutfey M et al. Independent origin of mono-rifampin-resistant
mycobacterium tuberculosis in patients with AIDS. Am J Respir Crit
Care Med. 1996;153:837-840.
Simpson D et al. Peptide T in the treatment of painful distal neuropathy
associated with AIDS: Results of a placebo-controlled trial. Neurology.
1996;44:1254-1259.
Bangsberg D et al. Reduction in tuberculin skin-test conversions among
medical house staff associated with improved tuberculosis infection
control practices. Infect Control Hosp Epidemiol. 1998;18:566-570.
Yin M, Dobkin JF, Brudney KF, Becker C, Zadel JL, Manandhar M,
Addesso-Dodd V, Shane E. Bone mass and mineral metabolism in HIV-infected
postmenopausal women. Osteoporos Int. 2005;16:1345-1352.
Dobkin J. Preventing pneumococcal disease. AIDS Reader. 2006.
16(2):81-2
AIDS Read. 2006 Feb;16(2):81-2.
OFFICE INFORMATION:
Harkness Pavilion, 6th Floor
180 Fort Washington Avenue
New York, NY 10032
Tel: 212-305-8507
Fax: 212-305-7692
E-mail: Jfd2@columbia.edu
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NAME: Alan Dunn, MD
ACADEMIC TITLE:
Assistant Clinical Professor of Medicine
EDUCATION:
New York University, 1967
New York Medical College, MD, 1971
SPECIALTY: Sexually transmitted diseases
OFFICE INFORMATION:
New York City Department of Health
Sexually Transmitted Disease Program
160 West 100th Street, Room 146
New York, NY 10025
Tel: 212-865-1951
E-mail: adunn@health.nyc.gov
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NAME: David A. Fidock, PhD
ACADEMIC TITLE:
Associate
Professor of Microbiology and Medicine
EDUCATION:
Adelaide University, South Australia B.Sc., 1986
University Paris VII, France, Ph.D.,
1994
SPECIALTY:
Malaria drug resistance, chemotherapy, pathogenesis, cell development
RESEARCH
SUMMARY:
A major focus of our group is to
elucidate the molecular basis of chloroquine resistance (CQR). By genetic
linkage and positional cloning, we earlier identified the pfcrt gene,
located within a chromosomal segment tightly linked to CQR, which encodes
a novel 10-transmembrane transporter located on the intra-erythrocytic
parasite’s digestive vacuole. Using allelic exchange techniques, we
recently proved that mutations in this gene, identified in drug resistant
parasites from around the globe, are sufficient to confer CQR to
CQ-sensitive parasites. Current work focuses on understanding the
contribution of the individual mutations to CQR, determining their impact
on parasite resistance to other antimalarials, and investigating the
biochemical basis of CQR. We are also developing animal models to explore
the role of pre-existing immunity on host clearance of drug-resistant
infections. In collaboration with Dr. Myles Akabas at AECOM, we are also
investigating the natural transport properties of pfcrt in heterologous
cells. Other studies focus on defining the role of PfATPase6, pfmdr1 and
pfnhe in contributing to parasite susceptibility to artemisinin, quinine
and mefloquine.
We are also deeply involved in a
major public/private partnership, funded by the Medicines for Malaria
Venture and the NIH, and including GlaxoSmithKline and several academic
partners, that aims to develop new antimalarial drugs that target fatty
acid biosynthesis in the malaria parasite.
Another aspect of our research is to
investigate the molecular basis of how parasitized erythrocytes bind to
host endothelium, enabling them to avoid splenic clearance. A variant
antigen family, PfEMP1, mediates this binding. We are investigating
mechanisms of gene regulation that contribute to this switching of gene
expression between different members of this family and exploring the
genetic basis of endothelial receptor specificity.
The
fourth area of research focuses on the digestive vacuole, the site of CQ
action. Specifically, we are examining which ER or Golgi proteins are
involved in protein trafficking to this compartment and using
transfection and bio-informatic approaches to define sequence motifs that
direct proteins to this site.
SELECTED
PUBLICATIONS:
Sisowath C,
Petersen I, Veiga IM, Martensson A, Premji Z, Bjorkman A, Fidock DA &
Gil JP (2008). In
vivo selection of P.
falciparum parasites carrying the chloroquine-sensitive pfcrt K76 allele
upon treatment with artemether-lumefantrine in Africa. J. Infect. Dis.
(in press).
Fidock DA, Eastmasn RE, Ward
SA & Meshnick SR (2008). Recent highlights in antimalarial drug
resistance and chemotherapy research. Trends
in Parasitol. (in press).
Lee MCS, Moura PA, Miller EA & Fidock DA (2008). Plasmodium falciparum
Sec24 marks transitional ER that exports a model cargo via a diacidic
motif. Mol.
Microbiol. 68: 1535-1546.
Greenwood BM, Fidock DA, Kyle
DE, Kappe SH, Collins FH & Duffy PE (2008). Malaria: progress,
perils, and prospects for eradication. J.
Clin. Invest. 118: 1266-1276.
Lee MCS & Fidock DA
(2008). Arresting malaria parasite egress from infected red blood cells. NatureChem. Biol. 4:
161-162.
Ekland EH & Fidock DA
(2007). Advances in understanding the genetic basis of antimalarial drug
resistance. Curr.
Opinion Microbiol. 10: 363-370.
Sidhu AB, Sun
Q, Nkrumah LJ, Dunne MW, Sacchettini JC & Fidock DA (2007). In vitro efficacy,
resistance selection, and structural modeling studies implicate the
malarial parasite apicoplast as the target of azithromycin. J. Biol. Chem. 282:
2494-504.
Nkrumah LN,
Muhle RA, Moura PA, Ghosh P, Hatfull G, Jacobs Jr. WR & Fidock DA
(2006). Efficient site-specific integration in Plasmodium falciparum
chromosomes mediated by mycobacteriophage Bxb1 integrase. Nature Methods
3: 615-21.
Lakshmanan V, Bray PG, Verdier-Pinard
D, Johnson DJ, Horrocks P, Muhle RA, Alakpa GE, Hughes RH, Ward SA,
Krogstad DJ, Sidhu ABS & Fidock DA (2005). A critical role for PfCRT
K76T in Plasmodium falciparum verapamil-reversible chloroquine
resistance. EMBO J. 24: 2294-305.
Johnson DJ,
Fidock DA, Mungthin M, Lakshmanan V, Sidhu ABS, Bray PG, & Ward SA*
(2004) Evidence for a central role for PfCRT in conferring Plasmodium falciparum
resistance to diverse antimalarial agents. Mol. Cell 15: 867-77.
*Co-corresponding authors.
Fidock DA, Rosenthal PJ, Croft SL, Brun R
& Nwaka S (2004). Antimalarial drug discovery: efficacy models for
compound screening. Nature Rev. Drug Disc. 3:
509-20.
Sidhu ABS,
Verdier-Pinard D & Fidock DA (2002). pfcrt mutations confer chloroquine
resistance to Plasmodium falciparum malaria parasites. Science 298: 210-3
Djimdé
A, Doumbo OK, Cortese JF, Kayentao K, Doumbo S, Diourté Y, Coulibaly D,
Dicko A, Su X-z, Nomura T, Fidock DA, Wellems TE, and Plowe CV (2001). A
molecular marker for chloroquine resistant falciparum malaria. New Engl.
J. Med. 344:257-63.
Fidock DA, Nomura T, Talley AK,
Cooper RA, Dzekunov SM, Ferdig MT, Ursos LM, Sidhu ABS, Deitsch K, Su
X-z, Wootton JC, Roepe PD & Wellems TE (2000). Mutations in the P. falciparum
digestive vacuole transmembrane protein PfCRT and evidence for their role
in chloroquine resistance. Mol. Cell 6:681-71.
OFFICE INFORMATION:
Department of Medicine and Microbiology
Hammer Health Sciences Center Room 1502
701 West 168th Street
New York, NY 10032
Tel: (212) 305-0816
Fax: (212) 305-4038
ACADEMIC TITLE:
Assistant Professor of Clinical Medicine
EDUCATION:
Dominican College of Blauvelt, BS, 1968
New York University, PhD, 1976
Teachers College, Columbia University, MA, 1983
Columbia College of Physicians and Surgeons, MD, 1987
SPECIALTY: General infectious diseases, HIV primary care, travel
medicine
RESEARCH SUMMARY:
With a background in cell biology and basic science research, Dr. Flood
focuses on clinical infectious diseases. Her interests include general
infectious diseases with a particular interest in HIV primary care,
infections in immunocompromised patients, endocarditis and septic
arthritis. Dr. Flood is also qualified to do travel recommendations and
immunizations.
SELECTED PUBLICATIONS:
Flood MT. "Infectious Arthritis." In: Current Practice of
Medicine. RC Bone MD ed. Current Medicine, Philadelphia 1996, VIII:
16.1-10.
Brunswick AF, Messeri PA, Dobkin J, Flood MT, Yang A. "Sibling
homophily in HIV infection: biopsychosocial linkages in an urban
African-American sample. NIDA Research Monograph 151, 1995
Blaner WS, Das Sr, Gouras P, Flood MT. "Hydrolysis of 11-cis and
all-trans retinyl palmitate by homogenates of human retinal epithelial
cells. J Biol Chem 262 (1987): 53-58.
Flood MT, Gouras P, Kjeldbye H. "Growth characteristics and
ultrastructure of human retinal pigment epithelium in vitro. Invest
Ophthal Vis Sci 19 (1980): 1309-1320.
OFFICE INFORMATION:
NewYork–Presbyterian Hospital
161 Fort Washington Avenue
Irving Pavilion, Room 221
New York, NY 10032
Tel: 212-305-8039
Fax: 212-305-1754
E-mail: mtf2@columbia.edu
ACADEMIC TITLE:
Assistant Professor of Clinical Medicine
EDUCATION:
Harvard University, BA, 1995
University of Pennsylvania School of Medicine, MD, 1999
Columbia University Mailman
School of Public Health, MS (Epidemiology), 2006
SPECIALTY: Clinical research in hospital epidemiology,
antimicrobial resistance, and community-associated methicillin-resistant Staphylococcus aureus
RESEARCH SUMMARY:
Dr E. Yoko Furuya is the assistant director of hospital epidemiology for
NewYork–Presbyterian Hospital, Columbia University Medical Center. Her
research interests are focused in the areas of hospital epidemiology and
antimicrobial resistance. She is a coinvestigator with Dr Franklin Lowy
on a CDC-funded study investigating the prevalence of and risk factors
for community-associated methicillin-resistant Staphylococcus aureus
in northern Manhattan. Other current projects include the evaluation of
hospital-specific empiric antibiotic guidelines on antibiotic utilization
and resistance and the creation of a computer assisted hospital infection
control surveillance system, which is a joint project with Infectious
Diseases, Epidemiology, and Biomedical Informatics.
SELECTED PUBLICATIONS:
Furuya EY, Lowy FD: Antimicrobial
strategies for the prevention and treatment of cardiovascular infections
including cardiothoracic surgery and device implants. Curr Opin Pharmacol 3:
464-9, 2003.
Sobieszczyk ME, Furuya EY, Hay CM, Pancholi
P, Della-Latta P, Hammer SM, Kubin CJ: Combination therapy with polymyxin
B for the treatment of multidrug-resistant Gram-negative respiratory
tract infections. J
Antimicrob Chemotherapy 54: 566-9, 2004.
Furuya EY, Cook HA, Lee M, Miller M,
Larson E, Hyman S, Della-Latta P, Mendonca E, Lowy FD:
Community-associated methicillin-resistant Staphylococcus aureus prevalence: how
common is it? A methodological comparison of prevalence ascertainment. Am J Infect Control
35: 359-66, 2007.
Furuya EY, Paez A, Srinivasan A, Cooksey R, Augenbraun M,
Baron M, Brudney K, Della-Latta P, Estivariz C, Fischer S, Flood M,
Kellner P, Roman C, Yakrus M, Weiss D, Granowitz EV: Outbreak of Mycobacterium abscessus
wound infections in US lipotourists who underwent abdominoplasty in the
Dominican Republic. Clin
Infect Dis 46: 1181-8, 2008.
OFFICE
INFORMATION:
Department
of Medicine
Division of Infectious Diseases
630 West 168th Street, Box 82
New York, NY 10032
Tel: 212-305-7185
Fax: 212-305-7290
E-mail: eyf2002@columbia.edu
ACADEMIC TITLE:
Assistant Professor of Clinical Medicine
EDUCATION:
SUNY at Stony Brook, BS, 1986
SUNY at Stony Brook, School of Medicine, MD, 1990
SPECIALTY: HIV primary care, HIV clinical trials, HIV/HCV
coinfection
RESEARCH SUMMARY:
Dr Gordon is an assistant professor of clinical medicine in the Division
of Infectious Diseases at CUMC and the medical director of the
NewYork–Presbyterian System Select Health, an HIV Special Needs Plan
(SNP). He is also a coinvestigator for the Adult AIDS Clinical Trials
Unit at CUMC and a principal investigator for industry-sponsored studies
of new antiretroviral agents.
OFFICE INFORMATION:
Harkness Pavilion, 6th Floor
180 Fort Washington Avenue
New York, NY 10032
Tel: 212-305-9396
Fax: 212-305-7692
E-mail: pgg2@columbia.edu
ACADEMIC TITLE:
Assistant Professor of Clinical Medicine
Assistant Professor of Clinical Epidemiology
EDUCATION:
Yale University, B.S., 1996
Vanderbilt University School of Medicine, M.D., 2000
Columbia University Mailman School of Public Health, M.P.H. 2004
SPECIALTY: Staphylococcal molecular epidemiology and pathogenesis
RESEARCH SUMMARY:
Dr Rachel Gordon is an instructor in clinical medicine in the Division of
Infectious Diseases at the Columbia University Medical Center.
Her research interests include the molecular epidemiology of
Staphylococcal colonization and disease as well as Staphylococcal
pathogenesis.
In a past project, she described two major Staphylococcus aureus clonal types
colonizing and infecting AIDS patients in a drug rehabilitation facility.
This research demonstrated instability of the mec element, which is responsible for
methicillin-resistance. Currently, she is completing a double-blinded,
randomized controlled trial of mupirocin vs. placebo in the same
population to see if nasal carriage and infection with S. aureus can be
reduced. Currently, Dr. Gordon is investigating the molecular
epidemiology and pathogenesis of S.
epidermidis in ventricular assist device-related infections.
She is also interested in bacterial infections in drug users.
SELECTED PUBLICATIONS:
Cespedes, C., B. Said-Salim, M. Miller, S.H. Lo, B.N. Kreiswirth, R.J.
Gordon ,
P. Vavagiakis, R.S. Klein, and F.D. Lowy FD. The clonality of Staphylococcus aureus
nasal carriage. J.
Infect. Dis. 2005;191(3):444-52.
Gordon, R.J.,
B. Quagliarello, C. Cespedes, M. Chung, H. de Lencastre, P. Vavagiakis,
M. Miller, B. Zeller, and F.D. Lowy. A Molecular Epidemiological
Analysis of 2 Staphylococcus
aureus Clonal Types Colonizing and Infecting Patients with
AIDS. Clin.
Infect. Dis. 2005;40:1028-1036.
Gordon, R.J. and F.D. Lowy.
Bacterial Infections in Drug Users. NEJM 2005; 353:1945-54.
Gordon, R.J., B. Quagliarello, and F.D. Lowy.
Ventricular assist device-related infections. Lancet Infect. Dis. 2006; 6:426-37.
Gordon, R.J. and F.D. Lowy. Pathogenesis of Methicillin-Resistant
Staphylococcus aureus Infection. Clinical Infectious Diseases 2008;
46:S350-9.
ABSTRACTS
Jankolovits, R., B. Quagliarello,
C. Cespedes, M. Miller, M. Chung, H. De Lencastre, B. Zeller, J.
Justman, and F.D. Lowy. Two clonal types of Staphylococcus aureus
dominate infection and nasal colonization in a NYC AIDS and drug
treatment facility. Slide presentation at the Interscience Conference on
Antimicrobial Agents and Chemotherapy (ICAAC), September, 2002.
Gordon, R. J., T. Martens, R. Wang,
Y. Naka, B. Scully, E. Blumberg, and F. Lowy. Diagnostic Criteria for
Diagnosing Ventricular Assist Device-Related Infections. Poster
presentation at the 46th ICAAC, September, 2006.
R.
Gordon, M. Bhat, C. Fairchild, J. Choe, U. Rawiel, D. Ascheim, M.
Slaughter, Y. Naka, F. Lowy. Ventricular Assist Device Recipients Share
Commensal S. epidermidis Clones and are Infected with Colonizing Strains.
Poster presentation at the 48th Annual ICAAC/IDSA 46th Annual Meeting,
October 2008.
R. Gordon, N. Chez, H. Jia, B. Zeller, M. Sobieszczyk, C. Brennan, K.
Hisert, M. Lee, P. Vavagiakis, F. Lowy. Monthly mupirocin decreases S.
aureus nasal colonization in HIV/AIDS patients. Poster presentation at
the 48th Annual ICAAC/IDSA 46th Annual Meeting, October 2008.
OFFICE INFORMATION:
Department of Medicine
Division of Infectious Diseases
630 West 168th Street, Box 82
New York, NY 10032
Phone: (212) 342-0109
Fax (212) 305-5794
ACADEMIC TITLE:
Assistant Professor of Clinical Medicine
SPECIALTY: Acute and
recent HIV-1 infection
RESEARCH SUMMARY:
Christine Hogan is an assistant professor in the Division of Infectious
Diseases at Columbia University Medical Center. She is a subinvestigator
in the AACTG, contributing to clinical trials of HIV therapeutics. She
also leads CUMC's Acute HIV Infection program, the purpose of which is to
identify persons with acute or recent HIV-1 infection, engage them in
comprehensive HIV care, and invite them to participate in clinical
trials. The clinical trials are part of the NIH-funded Acute Infection
and Early Disease Research Program (AIEDRP), a multisite pathogenesis and
clinical trials network in which Columbia participates. Dr Hogan is the
national protocol chair of a multisite protocol of treatment during early
HIV-1 infection which is being performed within the AACTG as well as
AIEDRP. Dr Hogan follows a panel of patients longitudinally in the
department's HIV clinic and precepts ID fellows during their outpatient
clinic experience. She is the course director for Microbiology/Infectious
Diseases, the second-year medical student course in infectious diseases
at Columbia University.
SELECTED PUBLICATIONS:
Hogan C, Hammer S. Host determinants in HIV infection and disease Part 1:
Cellular and humoral immune responses. Ann Intern Med.
2001;134:761-776.
Hogan C, Hammer S. Host determinants in HIV infection and disease Part 2:
Genetic factors and implications for antiretroviral therapeutics. Ann
Intern Med. 2001;134:978-996.
Louie M, Hogan C, Di Mascio M, Hurley A, Simon V, Rooney J, Ruiz N, Brun
S, Sun E, Perelson A, Ho D, Markowitz M. Determining the relative
efficacy of highly active antiretroviral therapy. J Infect Dis.
2003;187:896-900.
Louie M, Hogan C, Hurley A, Simon V, Chung C, Padte N, Lamy P, Flaherty
J, Coakley D, Di Mascio M, Perelson A, Markowitz M. Determining the
antiviral activity of tenofovir disoproxil fumarate in treatment-naïve
chronically HIV-1-infected individuals. AIDS. 2003;17:1151-1156.
Mehandru S, Poles MA, Tenner-Racz K, Horowitz A, Hurley A, Hogan C, Boden
D, Racz P, Markowitz M. Primary HIV-1 infection is associated with
preferential depletion of CD4+ T lymphocytes from effector sites in the
gastrointestinal tract. J Exp Med. 2004;200:761-770.
Mehandru S,
Wrin T, Galovich J, Stiegler G, Vcelar B, Hurley A, Hogan C, Vasan S,
Katinger H, Petropoulos CJ, Markowitz M. Neutralization profiles of newly
transmitted human immunodeficiency virus type 1 by monoclonal antibodies
2G12, 2F5, and 4E10. J Virol. 2004;78:14039-14042.
OFFICE INFORMATION:
630 West 168th Street, Box 82
New
York, NY 10032
Tel: 212-305-7185 Fax: 212-305-7290
E-mail: ch358@columbia.edu
ACADEMIC TITLE:
Assistant Professor of Clinical Epidemiology and Medicine
EDUCATION:
Yale University, BS, 1981
University of Rochester, MD, 1985
SPECIALTY: HIV primary care, antiretroviral therapy, metabolic
complications
RESEARCH SUMMARY:
Dr Justman is the associate director of the Center for Infectious Disease
Epidemiologic Research (CIDER). In addition, within the International
Center for AIDS Care and Treatment Programs (ICAP), she is director of the
University Technical Assistance program. Both CIDER and ICAP are part of
the Mailman School of Public Health, Columbia University. Dr Justman's
research interests are in the areas of microbicides and the metabolic
complications of antiretroviral agents. Within the NIAID-funded HIV
Prevention Trials Network (HPTN), she served as the principal
investigator of the Bronx–Lebanon HPTN site, and conducted two phase I
safety of vaginal microbicides in both HIV-infected and uninfected women
and couples. Dr Justman is a cochair of HPTN 059, a phase II extended
safety microbicide study which will enroll 200 women. She has worked with
the NIAID-funded Women's Interagency HIV Study (WIHS) and has several
publications on metabolic complications in this cohort. She also serves
as vice chair of the New York State AIDS Institute's Medical Care
Criteria Committee.
SELECTED PUBLICATIONS:
Justman JE, Benning L, Danoff A, Minkoff H, Levine A, Greenblatt RM,
Weber K, Piessens E, Eobinson E, Anastos K. Protease inhibitor use and
the incidence of diabetes mellitus in a large cohort of HIV-infected
women. J Acquir Immune Defic Syndr. 2003;32:298-302.
Tien PC, Cole SR, Williams CM, Li R, Justman JE, Cohen MH, Young M, Rubin
N, Augenbraun M, Grunfeld C. Incidence of lipoatrophy and lipohypertrophy
in the women's interagency HIV study. J Acquir Immune Defic Syndr.
2003;5:461-466.
Mulligan K, Anasos K, Justman J, Freeman R, Wichienkuer P, Robison E,
Hessol NA. Fat distribution in HIV-infected women in the United States:
DEXA substudy in the women's interagency HIV study. J Acquir Immune
Defic Syndr. 2005;38:18-22.
Danoff A, Shi Q, Justman J, Mulligan K, Hessol N, Robison E, Lu D,
Williams T, Wichienkuer P, Anaasotos K. Oral glucose tolerance and
insulin sensitivity are unaffected by HIV infection or antiretroviral
therapy in overweight women. Acquir Immune Defic Syndr.
2005;39:55-62.
Tien PC, Schneider MF, Cole SR, Justman JE, French
AL, Young M, DeHovitz J, Nathwani N, Brown TT. Relation of stavudine
discontinuation to anthropometric changes among HIV-infected women. J Acquir Immune Defic Syndr.
2007. 44(1):43-8.
Watts DH, Springer G, Minkoff H, Hillier SL, Jacobson
L, Moxley M, Justman J, Cejtin H, O’Connell C, Greenblatt RM. The
occurrence of vaginal infections among HIV-infected and high-risk
HIV-uninfected women: longitudinal findings of the women's interagency
HIV study. J Acquir
Immune Defic Syndr. 2006. 43(2):161-8.
El-Sadr WM, Mayer KH, Maslankowski L, Hoesley C, Justman
J, Gai F, Mauck C, Absalon J, Morrow K, Masse B, Soto-Torres L, Kwiecien
A. Safety and acceptability of cellulose sulfate as a vaginal microbicide
in HIV-infected women. AIDS. 2006. 20(8):1109-16.
Mayer KH,
Maslankowski LA, Gai F, El-Sadr WM, Justman J, Kwiecien A, Masse B,
Eshleman SH, Hendrix C, Morrow K, Rooney JF, Soto-Torres L; HPTN 050
Protocol Team. Safety and tolerability of tenofovir vaginal gel in
abstinent and sexually active HIV-infected and uninfected women. AIDS.
2006. 20(4):543-51.
OFFICE INFORMATION:
722 W 168th Street, Room 714
Columbia University Medical Center
New York, New York 10032
Tel: 212-342-0537
E-mail: jj2158@columbia.edu
Charles Knirsch, MD, MPH research has
integrated work with several Public-Private-Partnerships to collaborate
on disease control and elimination programs. This has involved work on
addressing information management for tuberculosis patient treatment
protocols and hospital epidemiology in New York to more recent
international sector collaborations on malaria with The National Institutes
of Health and The Centers for Disease Control and Prevention. Chuck
currently collaborates with The World Health Organization and The
International Trachoma Initiative on a program to eliminate blinding
trachoma by the year 2020.
SELECTED
PUBLICATIONS:
Pablos-Mendez A, Knirsch CA, Barr
RG, Lerner BH, Frieden TR. Noncompliance with antituberculosis treatment:
Predictors and consequences in New York City. Am J Med 1997;102:164-170.
Pablos-Mendez A, Blustein J,
Knirsch CA. The role of diabetes mellitus in the higher prevalence of
tuberculosis among Hispanics. Am
J Public Health 1997; 87:574-579.
Knirsch CA, Jain NL,
Pablos-Mendez A, Friedman C, Hripcsak G. Tuberculosis Detection and
Monitoring by an Automated Clinical Decision Support System. Infect Control Hosp Epidemiol
1998;19 (2) 94-100.
Hripcsak G, Knirsch CA, Jain
N, Stazesky RC, Pablos-Mendez A, Fulmer T. A health information network
for managing inner-city Tuberculosis: Bridging clinical care, public
health, and home care. Computers
and Biomedical Research 1999 Feb;32 (1):67-76.
Barr RG, Diez-Roux AV, Knirsch
CA, Pablos-Méndez A. Neighborhood poverty and the resurgence of
Tuberculosis in New York City, 1984 to 1992. Am J Public Health 2001
Sep;91(9):1487-93.
Mecaskey JW, Knirsch CA,
Kumaresan JA, Cook JA. The possibility of eliminating blinding trachoma. Lancet Infect Dis.
2003 Nov;3(11):728-34.
Noedl H, Krudsood S,
Chalermratana K, Silachamroon U, Leowattana W, Tangpukdee N, Looareesuwan
S, Miller RS, Fukuda M, Jongsakul K, Sriwichai S, Rowan J, Bhattacharyya
H, Ohrt C, Knirsch C. Azithromycin combination therapy with artesunate or
quinine for the treatment of uncomplicated Plasmodium falciparum malaria
in adults: a randomized, phase 2 clinical trial in Thailand. Clin Infect Dis. 2006
Nov 15;43(10):1264-71.
Noedl H, Krudsood S,
Leowattana W, Tangpukdee N, Thanachartwet W, Looareesuwan S, Miller RS,
Fukuda M, Jongsakul K, Yingyuen K, Sriwichai S, Ohrt C, Knirsch C. In vitro
antimalarial activity of azithromycin, artesunate, and quinine in
combination and correlation with clinical outcome. Antimicrob Agents Chemother.
2007 Feb;51(2):651-6.
Knirsch C. Trachoma: ancient
scourge, disease elimination, and future research. Curr Infect Dis Rep.
2007 Jan;9(1):21-8.
El-Tahtawy A, Glue P, Andrews
EN, Mardekian J, Amsden GW, Knirsch CA. The Effect of Azithromycin on
Ivermectin Pharmacokinetics – A Population Pharmacokinetic Model
Analysis. PLoS Negl
Trop Dis. 2008 May 14;2(5):e236.
OFFICE
INFORMATION:
Pfizer Inc.
235 East 42nd Street
New York, NY 10017
EDUCATION:
University of North Carolina at Chapel Hill, PharmD, 1998
SPECIALTY: Anti-infective pharmacology and therapeutics, antimicrobial
resistance and epidemiology, antifungal therapy
RESEARCH SUMMARY:
Dr Kubin is the clinical pharmacy manager in the Division of Infectious
Diseases at NewYork–Presbyterian Hospital, Columbia University Medical
Center and a board-certified pharmacotherapy specialist. Her research
interests focus on anti-infective treatment outcomes and the epidemiology
of multi-drug resistant pathogens. Dr Kubin is a member of the joint
Anti-Infective Subcommittee at NewYork–Presbyterian Hospital and co-spearheads
antimicrobial stewardship activities with Dr. Furuya. Current projects
include evaluating treatment outcomes and therapies for infections caused
by carbapenem-resistant organisms, evaluating the relationships of
antibiotic utilization and resistance within the hospital, and creating
microbiology and antibiotic utilization components of the
computer-assisted hospital infection control surveillance system
currently in development.
SELECTED ABSTRACTS AND PUBLICATIONS:
Zeana C, Kubin CJ, Della-Latta P, Hammer S. Vancomycin-resistant Enterococcus
faecium meningitis successfully managed with linezolid: Case report
and review of the literature. Clin Infect Dis. 2001 Aug
15;33(4):477-482.
Kubin CJ. Antimicrobial control programs. Semin Perinatol. 2002
Oct;26(5):379-386.
Sobieszczyk ME, Kubin CJ, Della-Latta P, Scully B. Antimicrobial use and
rate of vancomycin-resistant Enterococcus infections in
neutropenic patients on a hematology/oncology unit. Abstract presented
at: 41st Annual Meeting of the Infectious Diseases Society of America;
October 9-12, 2003; San Diego, CA.
Furuya EY, Sobieszczyk ME, Kubin CJ, Hay CM. Intraventricular polymyxin B
for the treatment of multi-drug resistant gram-negative bacillary
ventriculitis: Two successful cases. Abstract presented at: 41st Annual
Meeting of the Infectious Diseases Society of America; October 9-12,
2003; San Diego, CA.
Sobieszczyk ME, Furuya EY, Hay CM, Pancholi P, Della-Latta P, Hammer SM,
Kubin CJ. Combination therapy with polymyxin B for the treatment of multi-drug
resistant gram-negative respiratory tract infections. J Antimicrob
Chemoth. 2004 Aug;54(2):566-569.
Furuya EY, Kubin CJ, Yin MT, Lowy FD, Della-Latta P, Hammer SM.
Daptomycin experience and comparison with linezolid for the treatment of
vancomycin-resistant enterococcal bacteremia. Abstract presented at: 45th
Annual Meeting of the Interscience Conference on Antimicrobial Agents and
Chemotherapy; December 16-19, 2005; Washington, DC.
Kubin CJ, Lam S, Hammer SM, Della-Latta P, Yin MT. Impact of caspofungin
compared to fluconazole and lipid amphotericin B on outcomes in patients
with candidemia. Abstract presented at: 45th Annual Meeting of the
Interscience Conference on Antimicrobial Agents and Chemotherapy;
December 16-19, 2005; Washington, DC.
Kubin CJ, Dzierba A. The effects of continuous renal replacement therapy
(CRRT) on anti-infective therapy in the critically ill. J Oncol Pharm
Pract. 2005;18:109-117.
Wong
KK, Kubin CJ, Furuya EY. Characterization of Carbapenem-Resistant
Klebsiella pneumoniae and Comparison with Carbapenem-Susceptible
Klebsiella pneumoniae in Bacteremias. Abstract presented at: Annual
Meeting of the Infectious Diseases Society of America; October 4-7, 2007;
San Diego, CA.
Hu J, Yin MT, Furuya Y, Eschenauer G, Hartman B, Hammer SM, Lowy FD,
Kubin CJ. Outcomes in Patients Receiving Tigecycline for Infections due
to Multi-drug Resistant Gram-Negative Organisms. Abstract presented
at: 47th Annual Meeting of the Interscience Conference on Antimicrobial
Agents and Chemotherapy; September 17-20, 2007; Chicago, IL.
Patel SJ, Larson EL, Kubin CJ, Saiman L. A Review of Antimicrobial
Control Strategies in Hospitalized and Ambulatory Pediatric Populations.
Pediatr Infect Dis J 2007; 26(6):531-537.
Kubin CJ. Antimicrobial Stewardship Programs: Role in Optimizing
Infectious Disease Outcomes. Disease Management and Health Outcomes
2008; (in press).
OFFICE INFORMATION:
Department of Medicine
Division of Infectious Diseases
630 West 168th Street, Box 82
New York, NY 10032
Tel: 212-305-7185
Fax: 212-305-7290
E-mail: cck27@columbia.edu
ACADEMIC TITLE:
Professor of Medicine and Pathology
EDUCATION:
Columbia College BA, 1968
Columbia University College of Physicians and Surgeons, MD, 1972
SPECIALTY:Internal Medicine and Infectious
Diseases
RESEARCH SUMMARY:
Dr Franklin Lowy is a professor of medicine and pathology in the Division
of Infectious Diseases in the College of Physicians and Surgeons at Columbia
University. Dr Lowy's laboratory currently investigates the pathogenesis
and epidemiology of Staphylococcus
aureus and Staphylococcus
epidermidis infections.
Studies
on the pathogenesis of staphylococcal infections:
One area of
research his an investigation of the pathogenesis of staphylococcal
infections in patients with left ventricular assist devices (LVADs). The
laboratory is investigating the role of different S. aureus and S. epidermidis
surface proteins as mediators of adherence to explanted LVAD material.
The goal is to identify potential vaccine candidates. A multi-center
observational trial is also part of this project. The goal is to better
understand the epidemiology of LVAD-related infections.
A second laboratory-based project is an investigation of the pathogenesis
of community-associated methicillin-resistant S. aureus pneumonia.
This invasive infection has accounted for increasing morbidity and
mortality on the past few years. A mouse post-influenza model for S. aureus pneumoniahas
been developed to determine which bacterial genes are unregulated during
infections.
Studies
on the transmission of S.
aureus among high-risk populations:
Dr.
Lowy’s group is conducting studies on the transmission of S. aureus among high
risk populations including injecting and inhalation drug users in Bedford
Stuyvesant, Brooklyn, in New York State Prisons, and in the Dominican
population of Northern Manhattan. The goal of these studies is to gain a
better understanding of the factors that contribute to the dissemination
of S. aureus
among the high risk groups.
Cespedes C et al. The clonality of Staphylococcus
aureus nasal carriage. J
Infect Dis. 2005;191:444-452.
Gordon RJ et al. A molecular epidemiological analysis of 2 Staphylococcus aureus
conal types colonizing and infecting patients with AIDS. Clin Infect Dis.
2005;40:1028-1036.
Gordon RJ, Lowy FD. Bacterial infections in drug users. N Engl J Med.
2005;353:1945-1954.
Furuya EY,
Lowy FD. Antimicrobial-resistant bacteria in the community setting. Nature Microbiol Rev.
2006;4:36-45.
Arrecubieta C, Asai T, Bayern M, Loughman A., Fitzgerald J Ross, Shelton
CE, Baron HM, Dang NC, Deng M, Naka Y, Foster TJ, and Lowy FD. The role
of S. aureus
adhesions in the pathogenesis of ventricular assist device related
infections. J Infect
Dis. 2006;193:1109-1119.
Aiello AE, Lowy FD, Wright LN, Larson
EL. Meticillin-resistant Staphylococcus
aureus among US prisoners and military personnel: review and
recommendations for future studies. Lancet
Infect Dis. 2006;6:335-41.
Cook
HA, Furuya EY, Larson E, Vasquez G, Lowy FD. Heterosexual transmission of
community-associated methicillin-resistant Staphylococcus aureus. Clin Infect Dis.
2007;44:410-3.
Lowy,
F.D., Aiello, A.E., Bhat, M., Johnson-Lawrence, V.D., Lee, M., Burrell,
E., Wright, L.N., Vasquez, G. and Larson, E.L. Staphylococcus aureus colonization
and infection in New York State Prisons. J. Infect. Dis. 196:911-918,
2007.
Arrecubieta,
C., Lee, M., Macey, A., Foster, T.J. and Lowy, F.D. SdrF, a Staphylococcus epidermidis surface
protein, binds type 1 collagen. J. Biol. Chem. 282:18767-18776, 2007.
Lowy,
F. D. Secrets of a superbug. Nat. Med.13:1418-1420, 2007.
Gordon, R. and Lowy, F.D. Pathogenesis of methicillin-resistant Staphylococcus aureus
infection. Clin. Infect. Dis. 46:5350-359, 2008.
Lowy, F.D. Staphylococcal Infections In: Harrison’s Principles of
Internal Medicine, 17th edition. Editors: A. S. Fauci, E. Braunwald,
D.L. Casper, S. L. Hauser, D. L. Longo, J. L. Jameson
and J. Loscalzo. The McGraw- Hill Companies, Inc., p.872-881,
2008.
OFFICE
INFORMATION:
Department of Medicine
Division of Infectious Diseases
630 West 168th Street, 9-458
New York, NY 10032
Tel: 212-305-7185
Fax: 212-305-5794
E-mail: fl189@columbia.edu
ACADEMIC TITLE:
Adjunct Instructor in Clinical Medicine
EDUCATION:
Long Island University, BS, 1985
Morehouse School of Medicine, MD, 1995
SPECIALTY: General infectious diseases, substance abuse
OFFICE INFORMATION:
St. Luke's–Roosevelt Hospital Center
Addiction Institute of New York
Clark 6–Detoxification Unit
1111 Amsterdam Avenue
New York, NY 10025
E-mail: Wme150@columbia.edu
ACADEMIC TITLE:
Assistant Professor of Clinical Medicine and Clinical Epidemiology
EDUCATION:
Olivet Nazarene College, BA, 1979
Washington University School of Medicine, MD, 1984
Columbia University Mailman School of Public Health, MPH, 1996
SPECIALTY: General infectious diseases, HIV/AIDS, sexually transmitted diseases, infections in pregnancy
RESEARCH SUMMARY:
Dr Morrison is an assistant professor of clinical medicine in the Division of Infectious Diseases. She is the program director for the Nicholas A. Rango HIV Scholar's program at NewYork–Presbyterian Hospital. Dr Morrison is also the medical director of the HIV Counseling and Testing Service at NewYork–Presbyterian Hospital.
SELECTED PUBLICATIONS:
Morrison EAB et al. Human papillomavirus infection and other risk factors for cervical neoplasia: A case control study. Int J Cancer. 1991;49:6-13.
Morrison EAB et al. Self-administered home cervicovaginal lavage: A novel tool for the clinical/epidemiological investigation of genital HPV Infections. Am J Obstet Gynecol. 1992;167:104-107.
Morrison EAB et al. Quantitation may improve clinical utility. J Clin Micro. 1992;30:2539-2543.
Morrison EAB et al. Pregnancy and cervical infection with human papillomaviruses. Int J Gyn Obstet. 1996;54:125-130.
Morrison EAB et al. Low prevalence of cervical human papillomavirus infection in renal transplant recipients. Neph Dial Trans. 1996:1603-1606.
Morrison EAB et al. Development of a multi-item scale to quantitatively assess sexual behaviors and the transmission of high and low risk human papillomaviruses. Sex Trans Dis. 1998;25:509-515.
Morrison EAB and Levenson J. Medical Treatment and Occupational Exposure. In: Fernandez F and Ruiz P, eds. Psychiatric Aspects of HIV/AIDS. Philadelphia: Lippincott Williams and Wilkins; 2006:23-35.
OFFICE INFORMATION:
Harkness Pavilion, 6th Floor
180 Fort Washington Avenue
New York, NY 10032
Tel: 212-305-6328
E-mail: eam6@columbia.edu
EDUCATION:
SUNY at Albany, BA, 1994
NYU School of Medicine, MD, 2002
SPECIALTY: HIV primary
care
SELECTED PUBLICATIONS:
Olender S, Saito M, Apgar J, et al. "Low prevalence and increased
household clustering of Mycobacterium tuberculosis infection in high
altitude villages in Peru" Am J Trop Med Hyg. 2003 Jun;68(6):721-7.
Chiasson
MA, Massad LS, Olender S, Wright TC. HIV Infection in Women in Atlas of
AIDS. Mandell GL and Mildvan D editors, Fourth Edition. Current Medicine,
2007.
Sasadeusz J,
Audsley J, Mijch A, Baden R, Caro J, Hunter H, Matthews G, McMahon MA,
Olender SA, Siliciano RF, Lewin SR, Thio CL. The anti-HIV activity of entecavir:
a multicentre evaluation of lamivudine-experienced and lamivudine-naïve
patients. AIDS, 2008; 22(8):947-55.
OFFICE INFORMATION:
Harkness Pavilion, 6th Floor
180 Fort Washington Avenue
New York, NY 10032
Tel: 212-305-3174
Fax: 212-305-7692
E-mail: so2045@columbia.edu
ACADEMIC TITLE:
Assistant Professor of Clinical Medicine
EDUCATION:
University of Pennsylvania, BA, 1983
Mount Sinai School of Medicine, MD, 1987
SPECIALTY: General infectious diseases, travel medicine, immunizations
RESEARCH SUMMARY:
Dr Rudin consults as an infectious disease specialist on the inpatient service both at NewYork–Presbyterian Hospital and at Valley Hospital in Ridgewood, New Jersey, a Columbia community hospital affiliate. Specific areas of interest include infections in neurosurgical, urology, and transplant patients. Dr Rudin also provides comprehensive health care for travelers, including pretravel medical evaluations, immunizations, and posttravel diagnosis and treatment of tropical and travel-related illnesses.
RESEARCH SUMMARY:
Dr Scully is the chair of the Infection Control Committee at
NewYork–Presbyterian Hospital, and cochair of the Joint Infection Control
Committee and the Joint Subcommittee on Anti-infective Use. His research
interests are in nosocomial infections, transplant infectious disease,
and hospital epidemiology.
SELECTED PUBLICATIONS:
Argenziano et al. The influence of infection on survival and successful
transplantation in patients with left ventricular assist devices. J
Heart Lung Transplant. 1997;16:822-831.
Sinha et al. Infections during left ventricular assist device support do
not affect postransplant outcomes. Circulation.
2000;102III:194-199.
Knirsh CA et al. An outbreak of Legionella micdadei pneumonia in
transplant patients: Evaluation, molecular epidemiology, and control. Am
J Med. 2000;108:290-295.
Saiman L et al. Banning artificial nails from health care settings. Am
J Infect Control. 2002;11:252-254.
Lux JZ et al. Transfusion-associated babesiosis after heart transplant. Emerg
Infect Dis. 2003;9:116-119.
Farr M, Rubin AI, Mangurian C, Scully B et al. Late
syphilis in cardiac transplant patient. J Heart Lung Transplant. 2006 25(3):
358-61.
OFFICE INFORMATION:
Department of Medicine
Division of Infectious Diseases
630 West 168th Street, Box 82
New York, NY 10032
Tel: 212-305-7185
Fax: 212-305-7290
EDUCATION:
University of California, Berkeley, BA, 1996
NYU School of Medicine, MD, 2003
SPECIALTY: HIV primary care, correctional medicine
RESEARCH SUMMARY:
Dr. Noga Shalev is an Instructor in Clinical Medicine in the Infectious Diseases Division at the Columbia University College of Physicians. She is the recipient of the NIH LRP for the study of Health Disparities. Her research focuses on the evaluation of medical care in correctional settings and its impact on health inequities.
SELECTED ABSTRACTS AND PUBLICATIONS:
Shalev, N. From public to private care: the historical trajectory of medical services in a New York City jail. American Journal of Public Health, accepted December 2007.
Kluger M, Shalev N, Capponi L, Heinzerling K. Designing a clinical hepatitis screening and prevention program. 4th National Harm Reduction Conference, Seattle, WA, December 2002
Heinzerling K, Shalev N. Brief interventions to reduce harmful injection practices among drug users in health care settings. 4th National Harm reduction Conference, Seattle, WA December 2002
Yount GL, Afshar G, Ries S, Korn M, Shalev N, Basila D, McCormick F, Hass-Kogan DA. Transcription activation of TRADD mediated p53 independent radiation-induced apoptosis of glioma cells. Oncogene 2001;20:2826-35.
Shalev, N. Hepatitis Screening and vaccination at a syringe exchange. 3rd National Harm Reduction Conference, Plenary Session, Miami, FL, October 2000
Haas-Kogan DA, Shalev N, Wong M, Mills G, Yount G, Stokoe D. Protein Kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC. Current Biology 1998;8:1195-8.
OFFICE INFORMATION:
Harkness Pavilion, 6th Floor
180 Fort Washington Avenue
New York, NY 10032
Tel: 212-305-4707
Fax: 212-305-7692
E-mail: ns2413@columbia.edu
ACADEMIC TITLE:
Assistant Professor of Clinical Medicine
EDUCATION:
Harvard University, BA, 1994
Columbia College of Physicians and Surgeons, MD, 1998
Columbia University Mailman School of Public Health, MPH, 2006
SPECIALTY: HIV vaccine trials, international HIV, metabolic
complications of HIV therapy
RESEARCH SUMMARY:
Dr. Magdalena Sobieszczyk is an
Assistant Professor of Clinical Medicine in the Infectious Diseases
Division at the Columbia University College of Physicians. Her current research
experience includes complications of antiretroviral therapy, and HIV
vaccines. Under the auspices of the Center for Infectious Disease
Epidemiologic Research (CIDER), she is collaborating with Dr. Jessica
Justman at the Mailman School of Public Health to study the prevalence of
the metabolic syndrome and its association with inflammatory markers
among HIV-infected women in The Women’s Interagency HIV Study (WIHS)
cohort. She is a co-investigator of the Centre for the AIDS Program of
Research in South Africa (CAPRISA) project entitled “Viral Setpoint and
Clinical Progression in HIV-1 Subtype C Infection: The Role of
Immunological and Viral Factors During Acute and Early Infection” (Salim
Abdool Karim, PI). Dr. Sobieszczyk is also a co-PI for a study evaluating
the prevalence of insulin resistance among HIV-1 negative and recently
infected South African women in the Acute Infection Study cohort.
She is a co-investigator for the New
York HIV Vaccine Trials Unit at Columbia University and the New York Blood
Center and is involved in developing and chairing a national and
international HIV vaccine protocol.
SELECTED ABSTRACTS AND PUBLICATIONS:
Sobieszczyk ME, Kubin CJ, Della-Latta
P, Scully B. Antimicrobial use and rate of Vancomycin-resistant Enterococcus infections in neutropenic patients on a Hematology- Oncology unit. Abstract
presented at the 41st Annual Meeting of the Infectious Diseases Society
of America. October 2003.
Furuya EY, Sobieszczyk ME, Kubin CJ,
Hay CM. Intraventricular Polymyxin B for the treatment of multi-drug
resistant Gram-negative bacillary ventriculitis: Two successful cases.
Abstract presented at the 41st Annual Meeting of the Infectious Diseases
Society of America. October 2003.
Sobieszczyk ME, Furuya EY, Kubin CJ,
Hay CM. Efficacy and safety of Polymyxin B in the treatment of infections
caused by multi-drug resistant Gram-negative organisms. Journal of
Antimicrobial Chemotherapy. 2004 Aug; 54(2):566-9.
Sobieszczyk ME, Hay CM.
“Gender-Specific Issues in Non-HIV Viral Infections” in Principles of
Gender Specific Medicine. Edited by Marianne J. Lagato Academic Press May 2004.
Sobieszczyk ME, Coakley EP, Wilkin
TJ, Hammer, SM. Advances in antiretroviral therapy. Highlights of the
11th Conference on Retroviruses and Opportunistic Infections, February
8-11, 2004.
Topics in HIV Medicine. 2004 Mar-Apr;12(1):9-2
Mariller MM, Abramson D, Sobieszczyk
ME. The Validity of Self-Reported Clinical Markers and Medication
Regimens: A Pilot Study. CHAIN Report 2004-6. Submitted Nov 17, 2004.
Sobieszczyk ME, Talley AK, Wilkin T,
Hammer SM. Advances in antiretroviral therapy. Highlights of the 12th
Conference on Retroviruses and Opportunistic Infections, 2005. Topics in
HIV Medicine. 2005 Mar-April; 13(1):22-44.
Sobieszczyk ME, Jones J, Wilkin
T, Hammer SM. Advances in antiretroviral therapy. Highlights of the
13th Conference on Retroviruses and Opportunistic Infections, 2006.
Topics in HIV M edicine. 2006 April; 14(1):22-44.
Sobieszczyk ME, D.R. Hoover, K.
Anastos, K. Mulligan, T. Tan, C. Hyman, M.H. Cohen, S.R. Cole, J.
Justman, Women's Interagency HIV Study. Prevalence and predictors
of metabolic syndrome among HIV-positive and negative women. J Acquir
Immune Defic Syndr, 2008; 48:272-280
Sobieszczyk ME, Taylor B, Hammer SM. Antiretroviral Agents. In Clinical
Virology, Richman Whitley, Hayden, Third Edition, 2008.
Taylor BS, Sobieszczyk ME, McCutchan FE, Hammer SM. The Challenge of
HIV-1 Subtype Diversity. New England Journal of Medicine, 2008; 358:1590-1602
Mlisana K, Auld SC, Grobler A, van Loggerenberg F, Williamson C, Iriogbe
I, Sobieszczyk ME, Abdool Karim SS; CAPRISA Acute Infection Study Team.
Anaemia in acute HIV-1 subtype C infection. PLOS One, 2008; 3(2):e1626
K. Mlisana, A. Feinstein, M. Sobieszczyk, L. Werner, C. Williamson, F.
Van Loggerenberg, S. Abdool Karim, CAPRISA 002 Acute HIV Infection Study
Team. Clinical signs and symptoms of Aacute HIV subtype C infection among
South African women. AIDS 2008 - XVII International AIDS Conference
Abstract no. THPE0084. Manuscript in progress
M. Sobieszczyk, K. Mlisana, A. Feinstein, L. Werner, S. Auld, C.
Williamson, F. Van Loggerenberg, S. Abdool Karim, CAPRISA 002 Acute HIV
Infection Study Team3.
Metabolic syndrome in acutely HIV-infected South African women. AIDS 2008
- XVII International AIDS Conference Abstract no. THPE0088. Manuscript in progress
OFFICE
INFORMATION:
630 W 168th Street, Box 82
Columbia University Medical Center
New York, New York 10032
Tel: 212-305-7185
E-mail: mes52@columbia.edu
SPECIALTY:
HIV treatment in Spanish-speaking populations
RESEARCH SUMMARY: Dr. Taylor’s research focuses on the interactions
between mobility, antiretroviral adherence, and HIV treatment outcomes.
She is also interested in the relationship between antiretroviral
adherence, the acquisition of antiretroviral resistance, and treatment
failure. She works in the Dominican Republic and in Washington Heights,
New York.
SELECTED PUBLICATIONS and
ABSTRACTS:
Chiasson
M, Taylor B, Scheinmann R, Hirshfield S, Humberstone M, Remien R, Wolitski
R, Wong T. “Comparison of Sexual Risk Behaviors in Non-Hispanic Black and
White Men Who Have Sex with Men Recruited in Online Surveys.” Poster
Presentation. 15th Conference on Retroviruses and Opportunistic
Infections. Boston, Feb 2-6, 2008.
Taylor
BS, Sobieszczyk ME, McCutchan FE, Hammer SM. “The Challenge of HIV
Subtype Diversity.” New England Journal of Medicine. 2008; 358:1590-602. http://content.nejm.org/cgi/content/full/358/15/1590*
Dumortier
C, Taylor B, Sanchez E. J, Leon P, Rojas R, Rodriguez C, Yunen J, Olive
C, Bhat M, Lowy F. “Evidence of S. aureus transmission between the USA
and the Dominican Republic.” Poster Presentation. 48th Annual ICAAC/46th
Annual IDSA Meeting. Washington DC, October 25-29, 2008.
Bhat
M, Dumortier C, Taylor B, Miller M, Vasquez G, Yunen J, Brudney K,
Sánchez E. J, Leon C, Rodriguez-Taveras C, Rojas R, Lowy FD. “Detection
of Staphylococcus aureus ST398 in Northern Manhattan and the Dominican
Republic.” Emerging Infectious Diseases, 2009; 15(2):in press.
Hunt
G, Taylor B, Coovadia A, Abrams E, Sherman G, Meyers T, Morris L, Kuhn L.
“Development of Drug Resistance among a Cohort of HIV-infected Infants
Exposed to Nevirapine for pMTCT Initiating Protease-Inhibitor-based
Antiretroviral Therapy in South Africa.” Poster Presentation. 16th
Conference on Retroviruses and Opportunistic Infections. Montreal, Feb
8-11, 2009.
OFFICE INFORMATION:
630 W 168th Street, Box 82
Columbia University Medical Center
New York, New York 10032
Tel: 212-305-7185
Fax: 212-305-7290
E-mail: bs2026@columbia.edu
Columbia University Mailman School of Public Health, MS, 2009
SPECIALTY: HIV prevention and vaccine trials, TB and HIV co-infections in Southeast Asia
RESEARCH SUMMARY:
Dr. Hong Van Tieu is an Instructor of Clinical Medicine in the Division of Infectious Diseases at Columbia University, as well as an Associate Member in the Laboratory of Infectious Disease Prevention at the New York Blood Center. During fellowship at Columbia University, she studied immunologic markers to predict and diagnose tuberculosis-associated immune reconstitution inflammatory syndrome in HIV and TB co-infected adults in Thailand. She also investigated the acceptability of male circumcision to prevent HIV among high-risk Thai men. She is currently a co-investigator of a latent TB diagnosis study in HIV infected and uninfected children in Thailand. Hong's interests also include HIV prevention and vaccine trials. She is a co-investigator of the New York City site for the HIV Prevention Trials Network (HPTN) 061 study to prevent HIV infection among Black men who have sex with men. She is also involved in HIV vaccine studies with the Columbia University HIV Vaccine Trials Unit in collaboration with the New York Blood Center.
SELECTED ABSTRACTS AND PUBLICATIONS:
Tieu HV. Toxoplasma Pneumonitis in an AIDS Patient. Infectious Disease Images oral case presentation, Infectious Diseases Society of America Annual Meeting, Toronto, Ontario, Canada, October 12, 2006.
Tieu HV. "IDSA 2006 Fellows Day Case Summary: A Man with Dyspnea and Cough." December 2006. Partners Infectious Disease Images. Retrieved December 15, 2006 from Partners Infectious Disease Images 2006 <http://www.idimages.org>.
Tieu HV, Ananworanich J, Avihingsanon A, Apateerapong W, Sirivichayakul S, Klongugkara S, Boonchokchai B, Siangphoe U, Hammer S, Manosuthi W. Immunologic Markers as Predictors of TB-associated Immune Reconstitution Inflammatory Syndrome in HIV/TB Co-infected Persons in Thailand [Abstract 1008]. 15th Conference on Retroviruses and Opportunistic Infections, Boston, MA, February 3-6, 2008. Manuscript in progress.
Tieu HV, Phanuphak N, Ananworanich J, Pharachetsakul N, Mingkwanrungrueng P, Buajoom R, Teeratakulpisarn , Hammer S, Chiasson MA, Phanuphak P. Acceptability of Male Circumcision for Prevention of HIV among High-risk Heterosexual Men in Thailand [Abstract MOPE0547]. XVII International AIDS Conference, Mexico City, Mexico, August 3-8, 2008. Manuscript submitted.
Tieu HV, Xu G, Koblin B. Sexual Partnering and HIV Risk among Black Men Who Have Sex With Men in New York City [Abstract 1022]. 16th Conference on Retroviruses and Opportunistic Infections, Montreal, Canada, February 8-11, 2009. Manuscript in progress.
Yin M, Brust J, Tieu HV, Hammer SM. Antiviral Agents. In: Richman D, Whitley R, Hayden F, eds. Clinical Virology. Third ed. Washington, D.C.: ASM Press; 2009.
ACADEMIC TITLE:
Assistant Professor of Clinical Medicine and Clinical Epidemiology
EDUCATION:
Johns Hopkins University School of Arts and Sciences, BA, 1994
Johns Hopkins University School of Medicine, MD, 1998
Columbia University Mailman School of Public Health, MPH, 2004
SPECIALTY: TB and TB/HIV epidemiology, TB diagnostics
RESEARCH SUMMARY:
Dr. Simon
Tsiouris is assistant professor of clinical medicine and clinical
epidemiology at the Columbia University Medical Center and assistant
attending in infectious diseases at the New York–Presbyterian Hospital.
Dr Tsiouris's research interests include TB and HIV epidemiology, TB
diagnostics, and TB/HIV operational research. He has conducted a latent
TB infection survey of schoolchildren in a South African township and he has
been involved in a similar survey in Peru. His work in South Africa has
included the evaluation of the sensitivity of a TB-specific whole blood
interferon-gamma release assay. Dr. Tsiouris is co-investigator on a CDC
Tuberculosis Epidemiologic Studies Consortium-sponsored multi-site study
to evaluate new interferon-gamma release assays in the diagnosis of LTBI
in health care workers. He is also co-investigator on the NIH
sponsored East Africa International Epidemiologic Databases to Evaluate
AIDS (IeDEA) study. Dr. Tsiouris is also involved in an ongoing
study of the diagnosis of TB and LTBI in children in Thailand.
SELECTED
PUBLICATIONS:
El-Sadr WM and Tsiouris SJ*.
HIV-Associated Tuberculosis: Diagnostic and Treatment Challenges. Seminars
in Respiratory and Critical Care Medicine. 2008; 29(5): 525-531
*Corresponding author
M Gasana, G Vandebriel, G Kabanda, SJ Tsiouris*, J
Justman, R Sahabo, D Kamugundu, W El-Sadr. Integrating Tuberculosis and
HIV care in rural Rwanda. International Journal of Tuberculosis and
Lung Disease.2008; 12(3):S39–S43. *Corresponding author
Gasana M, Vandebriel G, Kabanda G, Mugabo J, Tsiouris SJ,
Ayaba A, Finlay A, Justman J, Sahabo R, El-Sadr W. Tuberculosis in
Rwanda: Challenges to reaching the targets. Bulletin of the World
Health Organization: Special theme: Tuberculosis control. 2007;
85(5):383-384.
SJ Tsiouris, NR Gandhi, WM. El-Sadr, G Friedland.
Tuberculosis and HIV, Needed: A New Paradigm for the Control and
Management of Linked Epidemics. eJournal of the International AIDS
Society Medscape General Medicine. 2007;9(3):62. Posted 09/25/2007.
Available at: http://www.medscape.com/viewarticle/561367
Y Hirsch-Moverman, S Tsiouris, J Salazar-Schicchi, PW
Colson, H Muttana, W El-Sadr. Physician Attitudes Regarding Latent
Tuberculosis Infection: International vs. U.S. Medical Graduates.
International Journal of Tuberculosis and Lung
Disease.2006;10(10):1178–1180.
SJ Tsiouris, D Coetzee, PL Toro, J Austin, Z Stein, W
El-Sadr. Sensitivity Analysis and Potential Uses of a Novel Gamma
Interferon Release Assay for Diagnosis of Tuberculosis. Journal of
Clinical Microbiology. 2006;44(8):2844-2850.
SJ Tsiouris, J Austin, P Toro, D Coetzee, K Weyer, Z
Stein, W El-Sadr. Results of a tuberculosis-specific IFN-γ assay in
children at high risk for tuberculosis infection. International
Journal of Tuberculosis and Lung Disease. 2006; 10(8):939-941.
M Saito, W Pan, R Gilman, C Bautista, S Bamrah, C Martin,
S Tsiouris, DF rguello, G Martinez-Carrasco. Comparison of altitude
effect on Mycobacterium tuberculosis infection between rural and urban
communities in Peru. American Journal of Tropical Medicine &
Hygiene. 2006; 75(1): 49–54.
Tsiouris S, Lowy FD. “Gender and Bacterial Infections” in
Principles and Practices of Gender Specific Medicine. 1st ed., Legato MJ,
editor. Academic Press, San Diego 2004.
Tsiouris SJ, Breschel TS, Xu J, McInnis MG, McMahon FJ.
Linkage disequilibrium analysis of G-olf alpha (GNAL) in bipolar
affective disorder. American Journal of Medical Genetics. 1996 Sep 20;
67(5):491-4.
SELECTED
ABSTRACTS:
Gasana M,
Vandebriel G, Gaspard K, Tsiouris S. Integrating Tuberculosis and
HIV Care in Rwanda, Oral presentation, the President’s Emergency Plan for
AIDS Relief Third Annual Field Meeting, 2006, Durban.
Vandebriel G, El-Sadr W,
Gasana M, Justman J, Koscelnik V, Tsiouris S. Increasing
collaboration and integration between TB and HIV programs and services in
Rwanda. Oral presentation, the President’s Emergency Plan for AIDS Relief
Second Annual Field Meeting, 2005, Addis Ababa.
OFFICE INFORMATION:
630 W 168th Street, Box 82
Columbia University Medical Center
New York, New York 10032
Tel: 212-305-7185
Fax: 212-305-7290
E-mail: st326@columbia.edu
ACADEMIC TITLE:
Assistant Professor of Clinical Medicine
EDUCATION:
Princeton University, BA, 1991
Columbia College of Physicians and Surgeons, MD, 1996
Columbia University Mailman School of Public Health, MS (Epidemiology),
2004
SPECIALTY: HIV therapy and metabolic complications
RESEARCH SUMMARY:
Dr Yin is an assistant professor of clinical medicine in the Division of
Infectious Diseases. Dr Yin's primary research interest is in the
metabolic complications of HIV infection and antiretroviral therapy. With
support from an NIH/NIAID K23 research career award, he is examining the
pathogenesis of HIV-associated bone loss in women utilizing novel
molecular assays and bone histomorphometry. He is a member of the
NIH-sponsored Women’s Health Interagency Study (WIHS) Metabolic Working
Group, and is the lead investigator for several bone metabolism related
analyses. He is also a site investigator in the AIDS Clinical
Trials Unit and the HIV Vaccine Trials Unit at Columbia University
Medical Center.
SELECTED PUBLICATIONS:
Yin M, Despommier D. Gender and parasitic infections. In: Legato,MJ, ed. Principles and Practices of
Gender-Specific Medicine. 1st ed. San Diego, CA: Academic
Press; 2004.
Yin M, Dobkin JF, Brudney KF, Becker
C, Zadel JL, Manandhar M, Addesso-Dodd V, Shane E. Bone mass and mineral
metabolism in HIV infected postmenopausal women. Osteoporosis International,
2005; 16(11):1345-52
Yin MT, Glesby M. Recombinant human
growth hormone (somatropin) therapy in HIV-associated wasting and
visceral adiposity. Expert
Review in Anti-Infective Therapy, 2005; 3(5): 727-38
Yin MT, Glesby M. Low Bone Mineral
Density, HIV, and Women: Fracture or Fiction? Clinical Infectious Diseases, 2006;
42(7):1021-3.
Yin MT, Shane E. Low bone mineral
density in patients with HIV: pathogenesis and clinical significance. Current Opinion in
Endocrinology and Diabetes, 2006; 13:497-502
Yin MT, Dobkin J, Grbric J. HIV
Infection and Associated Periodontal Manifestations. Periodontology 2000,
2007; 44: 1-27.
Yin MT, Brust JCM, Tieu HV, and Hammer SM. Antiherpesvirus, Antihepatitis Virus, and Anti-respiratory Virus Agents. In: Richman D, Whitley R and Hayden F, editors. Clinical Virology. 3rd ed.; Washington D.C.: ASM Press
Yin MT, Shane E, Anastos K. Clinical significance of HIV-associated bone loss: when and how to intervene. Future HIV Therapy, 2008;2(5):465-478.
Yin MT, Cremers S, Lu D, Shane E, Gao W, McMahon D, Anastos K. Short term bone loss in HIV infected premenopausal women. 15th Conference on Retroviruses and Opportunistic Infections: Boston, February 2008.
Stein EM, Yin MT, Shu A, McMahon DJ, Thomas V, Ferris D, Laurence J, Shane E. Vitamin D Insufficiency is Common in Racially Diverse Postmenopausal Women with Human Immunodeficiency Virus (HIV). American Society for Bone and Mineral Research 30th Annual Meeting, September, 2008
Shu AD, Yin MT, Ferris DJ, McMahon DJ, Eisenberg H, Thomas VK, Cabral S, Shane ES. Cortical and trabecular microarchitecture in postmenopausal HIV-infected women. American Society for Bone and Mineral Research 30th Annual Meeting, September, 2008
Yin MT, Ferris D, McMahon DJ, Cabral S, Eisenberg H, Laurence J, Thomas VK, Cremers S, Shane E. Determinants of low BMD in HIV infected postmenopausal women. American Society for Bone and Mineral Research 30th Annual Meeting, September, 2008
Modarresi R, Xiang Z, Yin M, Laurence J. WNT/B-catenin signaling is involved in regulation of osteoclast differentiation by HIV protease inhibitor ritonavir: relationship to HIV-linked bone demineralization, American Journal of Pathology, 2009; 174(5)123-145.
Yin MT, Ferris D, McMahon D, Laurence J, Eisenberg H, Cremers S, Shane E. Determinants of low bone density in postmenopausal women. 16th Conference on Retroviruses and Opportunistic Infections: Montreal, February 2009.
OFFICE INFORMATION:
Department of Medicine
Division of Infectious Diseases
630 West 168th Street, Box 82
New York, NY 10032
Tel: 212-305-7185
Fax: 212-305-7290
E-mail: mty4@columbia.edu
