Immunology
Center
College of Physicians and
Surgeons
Columbia
University
1. Introduction to Immunology - Course Number G4020 -
2002Rover Conference room, P&S 11-505, Tuesdays 2-3 PM and Thursdays 2-3 PM
Course Director - Paul Rothman Ext. 7-1984 / pbr3@columbia.edu
The textbook for the
course is "Immunobiology" edited by Janeway and Travers, which is available in
the Barnes and Noble bookstore.
Date Reading Lecture
1.
1/22
/02
Introduction- Rothman
2.
1/24
Clonal Selection; Structure of B/TCR proteins - Calame
3.
1/29
Organization of Ig and TCR genes - Calame
4.
1/31
Mechanism and regulation of VDJ recombination - Calame
5.
2/5
Antigen-independent phase of B-cell development -Rothman
6
2/7
B Cells- switch/hypermutation/Ig function - Calame
7.
2/12
Immune techniques and assays - Calame
8.
2/14
Discussion Section
9.
2/19
MHC Biology - Clynes
10.
2/21
off
11.
2/26
MHC Biology - Clynes
12.
2/28
T Cells- Effector Functions- Pernis
13.
3/5
T Cells- Thymic differentiation/restriction - Pernis
14.
3/7
T Cells- Activation - Pernis
15.
3/12
Tolerance to self - Pernis
16.
3/14
Germinal Center- Ag depend. B cell development- Calame
17.
3/19
Cytokines- Rothman
18.
3/21
Discussion Section
19.
3/26
Midterm Discussion
20.
3/28
Complement - Greenberg
21.
4/2
Innate immunity-effector functions - Greenberg
22.
4/4
Innate immunity-effector functions - Greenberg
23
4/9
Cytokine Signaling -Rothman
24.
4/11
Innate immunity-effector functions - Greenberg
25.
4/16
Hypersensitivity Reactions
Greenberg
26.
4/18
Autoimmunity - Rothman
27.
4/23
Discussion Section
28.
4/25
Acquired Immunodeficiency - Luban
29.
4/30
Congenital Immunodeficiency - Rothman
30.
5/2
Mucosal Immunity - Greenberg
31.
5/7
Discussion Section
32.
5/9
Review Section
33.
5/14
EXAM In class- open book
Revised: January 18, 2002