department of neurology  
  neurology  
  Address: The Neurological Institute of New York, 710 West 168th Street, 3rd Floor, New York, NY 10032  
 
 
 

BASIC SCIENTIFIC RESEARCH



ROBERT E. BURKE


(The Burke Laboratory website)
Studies of mechanisms of programmed cell death in models of neurodegeneration related to disorders of the basal ganglia, especially parkinsonism. Studies are conducted both in vivo and in vitro, utilizing immunohistochemistry, quantitative morphologic analysis, in situ hybridization, differential display, receptor autoradiography, and enzyme assays.

UN JUNG KANG



SHENG-HAN KUO



OREN LEVY



EUGENE MOSHAROV



SERGE PRZEDBORSKI


(Neuroscience Research Laboratory Website)
Study of toxin-induced damage to neurotransmitter systems pertinent to movement disorders such as Parkinson disease, amyotrophic lateral sclerosis and Huntington disease. Modes of cell death and free radical-induced toxicity are also investigated. SOD1 mutant transgenic mice serve as a model for amyotrophic lateral sclerosis. Methods include transgenic mice, immunohistochemistry, in situ hybridization, quantitative morphology, receptor binding, HPLC, and classical histology.

DAVID SULZER


(Sulzer Laboratory Website)
Study of dopamine synaptic plasticity and its pharmacological manipulation by drugs used for treatment of Parkinson disease and schizophrenia, as well as modulation by intrinsic synaptic proteins. Investigations also include mechanisms of addictive drugs associated with dopamine systems and cell culture models of catecholamine neurotoxicity and neurodegeneration. Methods include electrophysiology, electrochemistry, HPLC, quantitative microscopy, molecular biology, and neuronal cell culture.

AI YAMAMOTO







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Copyright © 2004 The Neurological Institute of New York || Columbia University Medical Center || Division of Movement Disorders
Affiliated with New York-Presbyterian Hospital
710 W 168th St, New York, NY 10032
Last updated: August 13, 2013
 

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