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Francis Y. Lee, M.D.
 •  Special Honors
 •  Academic Assignments (Present & Past)
 •  Research
 •  Publications
 •  Presentations
 
   



PRESENTATIONS:

 

  1. NFAT REGULATES LPS-INDUCED M-CSF EXPRESSION IN PRE-OSTEOBLASTIC CELLS. 53RD Annual Meeting of Orthopaedic Research Society, San Diego, 2007.
  2. CALCINEURIN/NFATC1 AXIS REGULATES UHMWPE WEAR PARTICLE-INDUCED CYTOKINE EXPRESSION IN BOTH PREOSTEOBLASTIC MC3T3-E1 CELLS AND RAW 264.7 CELLS. 53RD Annual Meeting of Orthopaedic Research Society, San Diego, 2007.
  3. NFAT AND ERK SIGNALING REGULATE M-CSF EXPRESSION INDUCED BY TITANIUM NANOPARTICLES IN MC3T3-E1 MURINE CALVARIAL PRE-OSTEOBLASTIC CELLS. 53RD Annual Meeting of Orthopaedic Research Society, San Diego, 2007.
  4. Kim, D W; Seo, S W; Ahn, J M; Lee, S E; Lee, H-J.; Lee, F Y : THE CALCINEURIN / NUCLEAR FACTOR OF ACTIVATED T CELL (NFAT) AXIS MEDIATES FLUID SHEAR STRESS-INDUCED COX-2 EXPRESSION IN MC3T3-E1 CELLS. 52ND Annual Meeting of Orthopaedic Research Society, Chicago, 2006.
  5. Kim, D W; Lee, S E; Seo, S W; Cho, S; Hei, T; Lee, F Y : DUAL SILENCING OF Bcl-2 and Bcl-XL GENES ENHANCES RADIOSENSITIVITY IN CHONDROSARCOMA. 52ND Annual Meeting of Orthopaedic Research Society, Chicago, 2006.
  6. Lee, H.-J., Kim, DW,*Kim, A., Tolchin, B., Ahn, JM, and Lee, FY : REGULATION OF THE RANKL/OPG RATIO BY FLUID SHEAR STRESS in MC3T3-E1 CELLS. 52ND Annual Meeting of Orthopaedic Research Society, Chicago, 2006.
  7. Suratwala, S J; Gardner, T R;  Seo S W;  Ahn J M;  Park, S H;  Yeh, J K; Lee, F Y : BISPHOSPHONATE/HYDROXYAPATITE COATED FEMORAL NAILS PRESERVE PERIPROSTHETIC BONE MASS AND EXHIBIT HIGHER FAILURE LOAD IN A RODENT OSTEOLYSIS MODEL. 52ND Annual Meeting of Orthopaedic Research Society, Chicago, 2006.
  8. Fujisawa M; Ankem HK; Moon YL; Minematsu H; Chang S-S; Lee HJ; Lee FY : Bigliani LU and Blaine TA: MECHANICAL STRAIN INDUCED ACTIVATION OF IL-6, COX-2 AND SDF-1 IN SUBACROMIAL BURSAL CELLS INVOLVES ERK (MAPK), P38, JNK AND NF-kb SIGNALING PATHWAYS. 52ND Annual Meeting of Orthopaedic Research Society, Chicago, 2006.
  9. Fujisawa M; Ankem HK; Moon YL; Minematsu H; Chang S-S; Lee HJ; Lee FY ; Bigliani LU and Blaine TA: MECHANICAL STRAIN INDUCES ACTIVATION OF INFLAMMATORY CYTOKINES IN SUBACROMIAL BURSAL CELLS: AN IN VITRO MODEL FOR SUBACROMIAL IMPINGEMENT. 52ND Annual Meeting of Orthopaedic Research Society, Chicago, 2006.
  10. Tolchin BD; Birk DM; Chang SS; Chung W; Cho SK; Kwon A; Lee HJ; Lee FY : MECHANICAL LOADING ALTERS THE EXPRESSION OF OSTEOGENIC AND OSTEOCLASTOGENIC REGULATORS IN VITRO   51st Annual Meeting of Orthopaedic Research Society, 2005.
  11. Karmin, J; Chang, S-S; Shrivastana, N; Lin S; Wang, D; Blaine, TA; Bigliani, LU; Lee FY ;  Lee, H-J: Small Interfering RNA (siRNA) Targeting Receptor for Advanced Glycation End Products (RAGE) Downregulates Stromal Cell Derived Factor 1 (SDF-1) in Rheumatoid Arthritis Cells. Annual Meeting of Orthopaedic Research Society, 2005.
  12. Fujisawa M; Kim, Y-S; Murakami, K; Chang, S-S; Lee, H-J; Lee FY ; Bigliani L ; Blaine TA: EXPRESSION PROFILE OF MATRIX/ADHESION MOLECULESIN SUBACROMIAL BURSITIS. 51st Annual Meeting of Orthopaedic Research Society, 2005.
  13. Kim, D W;  Abdelmessieh, P; Lin, S; Wang, D; Fujisawa M; Chang, S S; Lee, H J; Lee F Y : Neoplastic Chondrocytes of Chondrosarcoma Activate Bcl-2 Cell Survival Machinery and Inhibitors of Apoptosis Under Nutritional Deprivation. 51st Annual Meeting of Orthopaedic Research Society, 2005.
  14. Hong, D; Chung, WS; Shrivastava, N; Bigliani, LU; Lee FY, ;Lee HJ: CALPAIN IS A MEDIATOR OF RANKL INDUCED OSTEOCLASTOGENESIS OF MURINE  MACROPHAGES IN VITRO. 51st Annual Meeting of Orthopaedic Research Society, 2005.
  15. Fujisawa M, Kim Y-S, Murakami K, Abdelmessieh P, Chang, S-S, Lee, H-J, Blaine TA, and Lee FY ; FUNCTION OF A HECT DOMAIN UBIQUITIN LIGASE IN OSTEOBLAST DIFFERENTIATION. 51st Annual Meeting of Orthopaedic Research Society, 2005.
  16. Birk DM; Tolchin BD; Chang SS; Shrivastana N; Lee HJ; Blaine TA; Lee FY : The effect of mechanical strain on Osteoclastogenesis in RAW 264.7 Cells in Vitro . 51st Annual Meeting of Orthopaedic Research Society, 2005.
  17. Kim YS, Lee HJ, Chang SS,  Lee FY , Bigliani LU, Blaine TA: SDF-1 expression in shoulder bursitis. 51st Annual Meeting of Orthopaedic Research Society, 2005.
  18. Suratwala, S; Sinicropi. S; Lee, H J; Lee, F S, Vitale, M G; Roye, D P; Choi, I H, Delloye, C; Lee FY : Recombinant Human Bone Morphogenetic Proteins Are Not Sufficient To Induce Healing in Difficult Human Nonunions. 51st Annual Meeting of Orthopaedic Research Society, 2005.
  19. Suratwala S, Storer SK, Martin G, Yeh JK, Lee FY : The effect of bisphosphonates on allograft incorporation.Annual Meeting of American Academy of Orthopaedic Surgeons, 2005
  20. Lee FY , Suratwala, S, Yu J: Treatment of aggressive osteolytic benign bone lesions with topical antiresorptive agents:Scientific rationale and preliminary clinical results. Musculoskeletal Tumor Society, 2004
  21. Delloy C, Suratwala S, Lee FY : Lack of healing response in allograft surgeries. Musculoskeletal Tumor Society, 2004
  22. Lee FY et al: Recruitment of osteoclast precursor cells by stromal cell derived factor-1 in giant cell tumor of bone. 10th Workshop on Frontiers of Skeletal Biology, Davos, 2004.
  23. Lee FY , Suratwala, S, Yu J: Treatment of aggressive osteolytic benign bone lesions with topical antiresorptive agents: Part I.Scientific rationale. 10th Workshop on Frontiers of Skeletal Biology, Davos, 2004.
  24. Lee FY et al:  Treatment of aggressive osteolytic benign bone lesions with topical antiresorptive agents: Part II. Preliminary clinical results. 10th Workshop on Frontiers of Skeletal Biology, Davos, 2004.
  25. Lee FY et al: Diagnostic value and limitations of 18-FDG PET scan for cartilaginous tumors of bone. 2003 Musculoskeletal Tumor Society Meeting, Chicago, May 2003
  26. Lee FY et al: Anti-resorptive agent as a novel adjuvant therapy for giant cell tumor of bone. 2003 Musculoskeletal Tumor Society Meeting, Chicago, May 2003.
  27. Lee FY et al: Induction of Apoptosis in Giant Cell Tumor Cells. 30th European Symposium on Calcified Tissue, May 2003.
  28. MA Vitale, JC Choe, AM Sesko, JE Hyman, FY Lee , DP Roye, MG Vitale: The Effect of Leg Length Discrepancy on Health-Related Quality of Life: Is the "2cm Rule" Appropriate? American Academy of Orthopaedic Surgeons New Orleans, LA, 2003
  29. O Ugwonali, G Lomas, JC Choe, JE Hyman, FY Lee , MG Vitale, DP Roye: Effect of Bracing on the Quality of Life of Adolescents with Idiopathic Scoliosis.  Scoliosis Research Society, Seattle, WA, 2002
  30. SK Storer, MG Vitale DE Long, JC Choe, JE Hyman, FY Lee , DP Roye: Correction of Adolescent Idiopathic Scoliosis Using Thoracic Pedicle Screw Fixation vs. Traditional Hook Constructs: A Single Surgeon Retrospective Review. International Congress on Spinal Surgery Turkey, 2002
  31. MG Vitale JC Choe, MA Vitale, BD Roye, JE Hyman, FY Lee , DP Roye: Patient-Based Outcomes Following Clubfoot Surgery: A Fifteen Year Follow-Up Study. American Academy of Orthopaedic Surgeons. Dallas, TX, 2002
  32. MG Vitale DE Levy, JC Choe, AC Gelijns, AJ Moskowitz, JE Hyman, FY Lee , DP Roye : Pediatric Spine Deformity: Assessing Patient Outcomes and Quality of Life. International Congress on Spinal Surgery. Turkey, 2002
  33. MG Vitale, JC Choe, AC Gelijns, AJ Moskowitz, JE Hyman, FY Lee , DP Roye: Assessment of Health Status in Patients with Cerebral Palsy: What is the Role of Quality of Life Measures? International Society for Quality of Life Research. Amsterdam, 2001
  34. MG Vitale, JC Choe, MW Hwang, RM Bauer, JE Hyman, FY Lee , DP Roye: Postoperative Use of Ketorolac Tromethamine in Children Undergoing Scoliosis Surgery: An Analysis of Complications. North American Spine Society, New York, NY, 2002
  35. Lee FY , Heddon D, Alman B : Granulomatous foreign body reaction to metal wear debris following posterioir spine instrumentation for scoliosis. 69th Annual Meeting of American Academy of Orthopaedic Surgeons, Dallas, Texas, 2002.
  36. Lee FY , Osgood G, Parisien M, Dick HM: Cellular origin and osteolytic activity if the unicameral bone cyst. 1st Combined meeting of  International Bone and Mineral Society and European Connective Tissue Society, Madrid, Spain, 2001.
  37. Lee FY , Scanlan M, Ho M, Parisien M, Feldman F, Dick HM: Functional imaging of the cartilaginous bone tumors using positron emission tomography. 1st Combined meeting of  International Bone and Mineral Society and European Connective Tissue Society, Madrid, Spain, 2001.
  38. Lee FY , Ho M, Jayaraman T, Dick HM: Expression of cell death and calcium regulatory gene products during endochondral bone formation. 1st Combined meeting of  International Bone and Mineral Society and European Connective Tissue Society, Madrid, Spain, 2001.
  39. Lee FY , Ho M, Scanlan M, Parisien M, V Murty, T Jayaraman, Dick HM: Novel translocation t(9;12)(q12;q24) in secondary chondrosarcoma arising from hereditary multiple exostosis. 1st International Genetic Bone Disease Meeting, Davos, Switzerland, 2001.
  40. Lee FY , Storer S, Hazan EJ, Gebhardt MC, Mankin HJ: Repair of Bone Allograft Fracture Using Bone morphogenetic protein-2. 68th Annual Meeting of American Academy of Orthopaedic Surgeons, San Francisco, 2001.
  41. Lee FY , Hazan EJ, Snyder B, Gebhardt MC, Mankin HJ: Bone morphogenetic protein-2 can initiate and conduct repair process at allograft fracture sites. Annual Meeting of Musculo-Skeletal Tumor Society, Gainsville, Florida, May, 2000.
  42. Hyman J, Narayanan U, Lee FY , Alman B: Complications of flexible intramedullary nailing for femur fracture in children. The 67th Annual Meeting of  American Academy of Orthopapedic Surgeons, Orlando, Florida, 2000.
  43. Lee FY , Hazan EJ, Snyder B, Gebhardt MC, Mankin HJ: Bone morphogenetic protein-2 can initiate and conduct repair process at allograft fracture sites. Orthopaedic Research Society, Anaheim, CA, 1999*.
  44. Lee FY , Mankin HJ, Fondren G, Gebhardt MC, Springfield DS, Jennings LC: Clinical results of chondrosarcoma after surgical treatment. The 66th Annual Meeting of American Academy of Orthopaedic Surgeons, Anaheim, CA, 1999*.
  45. Ramappa A, Lee FY , Carson J, Hazan EJ, Gebhardt MC, Mankin HJ: The outcome of patients with chondroblastoma after surgical treatment. The 66th Annual Meeting of American Academy of Orthopaedic Surgeons, Anaheim, CA, 1999* (Manuscript Submitted, Pending).
  46. Richolt JA, Lee FY , Millis MB, Jaramillo D, Hresko T, Ready J, Gebhardt MC: Planning of musculoskeletal tumor surgeries using interactive three dimensional visulaization of MR imaging. The 66th Annual Meeting of American Academy of Orthopaedic Surgeons, Anaheim, CA, 1999*.
  47. Lee FY , Rocholt JA, Millis MB, Gebhardt MC: Planning of musculoskeletal surgeries using interactive 3-dimensional magnetic resonance iamging and computed tomography. The 66th Annual Meeting of American Academy of Orthopaedic Surgeons, Anaheim, CA, 1999*.
  48. Carson J, Mankin HJ, Gebhardt MC, Lee FY , Ramappa A, Hazan EJ: Osteoarticular femoral condyle allografts for osteochondral defects. The 66th Annual Meeting of American Academy of Orthopaedic Surgeons, Anaheim, CA, 1999*.
  49. Lee FY , Mankin HJ, Fondren G, Gebhardt MC, Springfield DS, Rosenberg A, Jennings LC: Chondrosarcoma of bone-An assessment of Outcome. The 4th International Combined Meeting of the American and European Musculoskeletal Tumor Societies, Washington, May, 1998*.
  50. Lee FY , Rho JY, Harten R, Arakal R, Zimmerman MC, Parsons JR, Behrens FF: Nanoindentation characteristics of the different zones of the articular cartilage. 30th Annual American Orthopaedic Association Residents' Conference, New York, New York, March, 1997*.
  51. Lee FY , Keem SS, Zimmerman MC, Dunn SD, Behrens FF: How safe is percutaneous iliosacral screw fixation under image control? Delinieation of the safe and blind zones in pelvic radiographs. Poster Exhibit, 64th Annual Meeting of American Academy of Orthopaedic Surgeons & 43rd Annual Meeting of Orthopaedic Research Society, San Francisco, California, 1997*.
  52. Lee FY , Choi YW, Behrens FF, DeFouw DO, and Einhorn TA: Synchronous removal of chondrocytes during fracture healing - Evidence for programmed and nonprogrammed cell death -, The 5th Meeting of the International Society for Fracture Repair, Ottawa-Hull, Canada, 1996.
  53. Lee FY , Harten R, Zimmerman MC, and Behrens, FF: In situ characterization of the regional and temporal variations in the acoustic properties of fracture callus, The 5th Meeting of the International Society for Fracture Repair, Ottawa-Hull, Canada, 1996.
  54. Lee FY , Behrens FF, DeFouw DO, and Einhorn TA: Synchronous cell removal during fracture healing: Evidence for programmed and nonprogrammed cell death. 109th Annual Meeting of American Orthopaedic Association, Colorado Springs, Colorado, 1996.
  55. Lee FY , Keem S, Zimmerman M, Dunn S, and Behrens F: Percutaneous iliosacral screw fixation under image control - Is it safe?, American Fracture Association, Philadelphia, Pennsylvania, 1996.
  56. Lee FY , Behrens FF, DeFouw DO, and Einhorn TA: Synchronous cell removal during fracture healing: Evidence for programmed and nonprogrammed cell death. Orthopaedic Research Society, Atlanta, Georgia, 1996*.
  57. Lee FY , Lee FS, Behrens, FF, DeFouw DO, and TA Einhorn: In situ cell death in physiologic turnover of articular chondrocytes. Orthopaedic Research Society, Atlanta, Georgia, 1996*.
  58. Harten RD, Zimmerman MC,  Lee FY ,  and Alberta F: Corticotomy method improves the acoustic properties of bone regenerate in the early phase of limb lengthening, Orthopaedic Research Society, Atlanta, Georgia, 1996*.
  59. Harten RD, Lee FY , Hurowitz EJ, Arakal RJ, Zimmerman MC, and Behrens FF: Regional and temporal changes in the acoustic properties of fracture callus in secondary bone healing. Orthopaedic Research Society, Atlanta, Georgia, 1996*.
  60. Lee FY , Schenk RS, Aurori BF, and Aurori KC: Pinless external skeletal fixation in the tibia - A preliminary report on indications and results. 63rd Annual Meeting of American Academy of Orthopaedic Surgeons, Atlanta, Georgia, 1996*.
  61. Lee SH, Lee FY , Kim DJ, Kim HG, Lee KH et al: Diagnosis of metastatic bone tumor using Tc-99m labeled antigranulocyte antibody bone marrow immunoscintigraphy. Joint meeting EMSOS-AMSTS, Florence, Italy, 1995.
  62. Lee HK, Lee SH, Kim DJ, and Lee FY : Limb salvage with tumor prosthesis for osteosarcoma of distal tibia and fibula. 8th International Symposium on Limb Salvage, Florence, Italy, 1995.
  63. Harten RD, Zimmerman MC, Weiss S, and Lee FY : Limb lengthening rates affect micromechanical properties of distraction callus. 21st Annual Meeting of the Society for Biomaterials, San Francisco, California, 1995.
  64. Lee HK, Chung MS, Kim HJ, Lee FY , Lee SH, Lee SY: An experimental study on the changes in biomechanical property, bone density and the area of trabeculae of osteoporotic bone. 60th Annual Meeting of American Academy of Orthopaedic Surgeons, San Francisco, California, 1993*.
  65. Kim YM, Kim HJ, Lee FY , Koo KH, and Ahn JH: Changes of bone scanning before and after cementless hip replacement arthroplasties. 59th Annual Meeting of American Academy of Orthopaedic Surgeons, Washington D.C., 1992.
  66. Lee FY , and Chung MS: Biomechanical chnages of tendon at various tension speed. 5th International Federation of Surgery of the Hand, Paris, France, 1992.
  67. Lee DY, Choi IH, and Lee FY : Surgical reconstruction of old unreduced congenital dislocation of the hip in adolescence and late childhood - New modified Klisic-Colonna procedure. Pediatric Orthopaedic Society of North America, 1991.