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 | Amy MacDermott, Ph.D. Professor of Physiology & Cellular Biophysics, Director of Graduate Studies Email: abm1@columbia.edu Website: http://cpmcnet.columbia.edu/dept/physio/macdermott/ Tel: (212) 305-3889 Office: BB 11-1109 Fax: (212) 305-5775 |
| CURRENT RESEARCH REGULATION OF SYNAPTIC TRANSMISSION IN THE SUPERFICIAL DORSAL HORN. Nociceptors carrying pain input from the periphery terminate in the superficialaspect of the spinal cord dorsal horn. The input travels along primary afferentaxons of the dorsal root ganglia and its excitatory signal is transmitted bythe release of glutamate, substance P and possibly ATP onto target dorsal hornneurons. In this laboratory, we use electrophysiological, optical, and immunocytochemicaltechniques to study the regulation of synaptic transmission in the superficialdorsal horn. We have been investigating the specific role of glutamate, substanceP and ATP in synaptic transmission, synaptic plasticity, and development of synapsesin the spinal cord dorsal horn. SELECTED PUBLICATIONS Tong, C.K., and MacDermott, A.B. 2006. Both Ca2+ permeable and impermeable AMPA receptors are expressed at synapses between primary afferents and subpopulations of rat dorsal horn. J Physiol. 575(Pt 1):133-44. Torsney, C., Anderson, R.L., Ryce-Paul, K.A.G., and MacDermott, A.B. 2006. Characterization of sensory neuron subpopulations selectively expressing green fluorescent protein in phosphodiesterase 1C BAC transgenic mice. Mol Pain, 2(1):17. Torsney, C., and MacDermott, A.B. 2006. Disinhibition opens the gate to pathological pain signaling in superficial NK1 receptor expressing neurons in rat spinal cord. J Neurosci. 26(6):1833-43. Engelman, H.S., Anderson, R.A., Daniele, C., MacDermott, A.B. 2005. Presynaptic alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors modulate release of inhibitory amino acids in rat spinal cord dorsal horn. Neuroscience. 2006;139(2):539-53 Zhuo, M., Caterina, M., Macdermott, A.B., Malmberg, A., Neugebauer, V., 2005. Yoshimura, M. Molecular pain, a new era of pain research and medicine. Mol Pain 1(1):1. Torsney, C., and MacDermott, A.B. 2004. AMPA receptors bring on the pain. Neuron, 44(4):577-8. Engelman, H.S., and MacDermott, A.B. 2004. Presynaptic ionotropic receptors in the central nervous system. Nature Review Neuroscience, 5:135-45. Lee, C.J., Labrakakis, C., Joseph, D.J., and MacDermott, A.B. 2004. Functional similarities and differences of AMPA and kainate receptors expressed by cultured rat sensory neurons. Neuroscience 129(1):35-48. Bardoni, R., Toursney, C., Tong, C.K., Prandini, M., and MacDermott, A.B. 2004. Presynaptic NMDA receptors modulate glutamate release from primary sensory neurons in rat spinal cord dorsal horn. J Neurosci. 24(11):2774-81.
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