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Eric R. Kandel, M.D.
Professor of Physiology & Cellular Biophysics,
Biochemistry & Molecular Biophysics, and Psychiatry
Email: erk5@columbia.edu
Tel: (212) 543-5202
Office: PI Annex, 664
Fax: (212) 543-5474


CURRENT RESEARCH

CELLULAR AND MOLECULAR MECHANISMS OF ASSOCIATIVE AND NON-ASSOCIATIVE LEARNING.

Cell and molecular mechanisms of associative and nonassociative learning. We combine behavioral, cellular, and molecular biological approaches to delineate the changes that underlie simple forms of learning and memory in invertebrates and vertebrates. In invertebrates the focus of our research is on the gill-withdrawal reflex of Aplysia.  We study three elementary forms of learning: habituation, sensitization , and classical conditioning. Recently we have reconstituted critical components of this learning in dissociated cell culture, and we now use the reconstituted system to examine the molecular mechanisms which contribute to short-and long-term memory. In vertebrates we use genetically modified mice to examine the mechanisms of long-term potentiation in the mammalian hippocampus and its relation to spatial memory and maintenance.


SELECTED PUBLICATIONS

Saxe, M.D., Malleret, G., Vronskaya, S., Mendez, I., Garcia, A.D., Sofroniew, M.V., Kandel, E.R., and  Hen, R. 2007. Paradoxical influence of hippocampal neurogenesis on working memory.  PNAS 104:4642-4646.

Touzani, K., Puthanveettil, S.V., and  Kandel, E.R.  2007.  Consolidation of learning strategies during spatial working memory task requires synthesis in the prefrontal cortex.  PNAS 104:5632-5637.

Huang, Y-Y., and  Kandel, E.R. 2007. 5-Hydroxytryptamine induces a protein kinase A/mitogen-activated protein kinase-mediated and macromolecular synthesis-dependent late phase of long-term potentiation in the amygdala. J Neurosci 27(12):3111-3119.

Lee, S.H, Lim, C.S, Park, H., Lee, J.A., Han, J.H., Kim, H., Cheang, Y.H., Lee, SH., Lee, Y.S., Ko, H.G., Jang, D.H., Kim, H., Miniaci, M.C., Bartsch, D., Kim, E., Bailey, C.H., Kandel, E.R., and Kaang, B.K. 2007. Nuclear translocation of CAM-associated protein activates transcription for long-term facilitation in Aplysia. Cell 129:801-812.

Huang, Y.Y., and Kandel, E.R. 2007. Low-frequency stimulation induces a pathway-specific late phase of LTP in the amygdala that is mediated by PKA and dependent on protein synthesis. Learn Mem 14:497-503.

Drew, M.R., Simpson, E.H., Kellendonk, C., Herzberg, W.G., Lipatova, O., Fairhurst, S., Kandel, E.R., Malapani, C., and Balsam, P.D. 2007. Transient overexpression of striatal D2 receptors impairs operant motivation and interval timing. J Neurosci 27(29):7731-7739.

Mayford, M., Mansuy, I.M., Muller, R.U., and Kandel, E.R. 1997. Memory and behavior: a second generation of genetically modified mice. Current Biology, 7:R580-R589.

Martin K.C., Casadio, A., Zhu, H., E.Y., Rose, J.C., Chen, M., Bailey, C.H., and Kandel, E.R. 1997. Synapse-specific, long-term facilitation of Aplysia sensory to motor synapses: A function for local protein synthesis in memory storage. Cell, 91:927-938.


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