James Rothman, Ph.D.

Professor of Physiology & Cellular Biophysics
Russ Berrie Med Sc Pav
1150 St Nicholas Ave 520
E-mail: jr2269@columbia.edu


Tel: MS 1-5565
(212) 851-5565
Fax: (212) 851-5570



CURRENT RESEARCH - (See  Rothman Lab;  and Columbia Genome Center)

1) ELUCIDATING THE UNDERLYING MECHANISMS OF TRANSPORT WITHIN CELLS

2) HIGH THROUGHPUT CELL BIOLOGY


SELECTED PUBLICATIONS

Yamamoto, A. et al. 2006. Autophagy-mediated clearance of huntingtin aggregates triggered by the insulin-signaling pathway. J. Cell Biol. 172, 719-31.

Antinozzi, P.A. et al. 2006. Functional mapping of disease susceptibility loci using cell biology. PNAS 103, 3698-703.

Giraudo, C.G. 2006. et al. A clamping mechanism involved in SNARE-dependent exocytosis. Science 313, 676-80.

Becker, T., Volchuk, A., Rothman, J.E. 2005. Differential use of endoplasmic reticulum membrane for phagocytosis in J774 macrophages. Proc Natl Acad Sci U S A 102, 4022-6.

Cosson, P. et al. 2005. Dynamic transport of SNARE proteins in the Golgi apparatus. Proc Natl Acad Sci U S A 102, 14647-52.

Paumet, F., Rahimian, V., Di Liberto, M., and Rothman, J.E. 2005. Concerted auto-regulation in yeast endosomal t-SNAREs. J Biol Chem 280, 21137-43.

Giraudo, C.G. et al. 2005. SNAREs can promote complete fusion and hemifusion as alternative outcomes. J. Cell Biol. 170, 249-60.

Fix, M. et al. 2004. Imaging single membrane fusion events mediated by SNARE proteins. Proc Natl Acad Sci U S A 101, 7311-6.

Fukasawa, M., Varlamov, O., Eng, W.S., Sollner, T.H., 2004. Rothman, J.E. Localization and activity of the SNARE Ykt6 determined by its regulatory domain and palmitoylation. Proc Natl Acad Sci U S A 101, 4815-20.

Paumet, F., Rahimian, V., and Rothman, J.E. 2004. The specificity of SNARE-dependent fusion is encoded in the SNARE motif. Proc Natl Acad Sci U S A 101, 3376-80.

Varlamov, O. et al. 2004. i-SNAREs: inhibitory SNAREs that fine-tune the specificity of membrane fusion. J Cell Biol 164, 79-88.

Volchuk, A. et al. 2004. Countercurrent distribution of two distinct SNARE complexes mediating transport within the Golgi stack. Mol Biol Cell 15, 1506-18.

Hu, C. et al. 2003. Fusion of cells by flipped SNAREs. Science 300, 1745-9.



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