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Joseph A. Gogos, M.D., Ph.D. Assistant Professor of Physiology & Cellular Biophysics E-mail: jag90@columbia.edu Tel: (212) 305-0744 Office: P&S 11-518 Fax: (212) 305-5775 |
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CURRENT RESEARCH ASSEMBLY AND MAINTENANCE OF SENSORY MAPS IN THE BRAIN; ANIMAL MODELS FOR GENES PREDISPOSING TO PSYCHIATRIC DISORDERS. We are using powerful techniques that permit us to control the survival and synaptic transmission of specific subsets of olfactory neurons in a temporally and spatially regulated manner, to investigate a) how precise connections between the periphery and the brain are continually maintained to preserve the integrity of the olfactory sensory maps, b) to examine whether there is modularity in the assembly of these maps and c) to probe the role of activity-dependent plasticity in the establishment, maintenance, and refinement of the olfactory sensory projections. We are also collaborating with Dr. Karayiorgou's lab at Rockefeller University to follow-up genetic findings from families afflicted with schizophrenia and other psychiatric disorders, by generating transgenic mouse lines for candidate susceptibility genes in order to a) strengthen or weaken our hypotheses for a role of these genes in disease susceptibility and b) facilitate understanding of the function of these genes and how they may impact on the development of psychiatric disorders. SELECTED PUBLICATIONS Paterlini, M., Zakharenko, S.S., Lai W-S, Qin, J., Zhang, H., Mukai, J., Westphal, K.G.C., Olivier, B., Sulzer, D., Pavlidis, P., Siegelbaum, S.A., Karayiorgou, M., and Gogos, J.A. 2005. Transcriptional and behavioral interaction between 22q11.2 orthologs modulates schizophrenia-related phenotypes in mice. Nature Neuroscience, 8(11):1586-94. Yu, C.R., Power, J., Barnea, G., OÍDonnell, S., Brown, H.E.V., Osborne, J., Axel, R. and Gogos, J.A. 2004. Spontaneous neural activity is required for the establishment and maintenance of the olfactory sensory map. Neuron 42, 553-566. Eggan, K., Baldwin, K., Tackett, M., Osborne, J., Gogos, J.A., Chess, A., Axel, R., and Jaenisch, R. 2004. Mice cloned from olfactory sensory neurons. Nature 428, 44-49. Emamian, E.S., Hall, D., Birnbaum, M.J., Karayiorgou, M., Gogos, J.A. 2004. Convergent evidence for impaired AKT1-GSK3beta signaling in schizophrenia. Nature Genetics 36, 131-137. Mukai, J., Liu, H., Burt, R.A. , Swor, D.E., Lai, W-S., Karayiorgou, M., and Gogos, J.A. 2004. Evidence that the gene encoding ZDHHC8, a putative transmembrane palmitoyltransferase, contributes to the risk of the 22q11-associated schizophrenia Nature Genetics 36, 725-731. Gerber, D.J., Hall, D., Miyakawa, T., Demars, S., Gogos, J.A., Karayiorgou, M., and Tonegawa, S. 2003. Evidence for association of schizophrenia with genetic variation in the 8p21.3 gene, PPP3CC, encoding the calcineurin gamma subunit. Proc Natl Acad Sci USA 100, 8993-8998. Liu, H., Heath, S.C., Sobin, C., Roos, J.L., Galke, B.L., Blundell, M.L., Lenane, M., Robertson, B., Wijsman, E.M., Rapoport, J.L., Gogos, J.A., and Karayiorgou, M. 2002. Genetic variation at the 22q11 PRODH2/DGCR6 locus presents an unusual pattern and increases susceptibility to schizophrenia. Proc Natl Acad Sci USA 99, 3717-3722. Liu, H., Abecasis, G.R., Heath, S.C., Knowles, A., Demars, S., Chen, Y.J., Roos, J.L., Rapoport, J.L., Gogos, J.A., Karayiorgou, M. 2002. Genetic variation in the 22q11 locus and susceptibility to schizophrenia. Proc Natl Acad Sci USA 99, 16859-16864. Gogos, J.A., Osborne, J., Nemes, A., Mendelsohn, M., 2000. Axel, R. Genetic Ablation and Restoration of the Olfactory Topographic Map. Cell 103, 609-620. |
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