By Car: From Eastside

FDR Drive Southbound: Use 63rd Street exit
FDR Drive Northbound: Use 61st Street exit

By Car: From Westside

Westside Highway Northbound: Use 57th Street exit
Westside Highway Southbound: Use 56th Street exit

By Public Transportation

#4, 5 and 6 trains to 59th Street (at Lexington Ave)
N, R, W trains to 5th Ave station (at 60th Street)
City buses also serve Columbia Eastside
Madison Ave buses travel uptown
Fifth and Lexington Ave buses travel uptown
There is a cross-town bus (M-28) on 57th Street