1999 Annual Report
Table of Contents

CRR Director: Eric J. Hall
Editor: Charles R. Geard
Asst Editors: Micaela J. Delegtianis
                    Mary T. Coady


The complete 1999 annual report can be downloaded as a PDF as can individual sections of this report from the links below. The table of contents is given below.

For annual reports from previous years click here.

Physics, Biophysics, and Risk Estimation [PDF]

Technical Characteristics of the Columbia University Single-Ion Microbeam
Gerhard Randers-Pehrson, Charles R. Geard, Gary W. Johnson, and David J. Brenner

Electrostatic Lens Design for the Columbia Microbeam
Alexander D. Dymnikov, David J. Brenner, Gary Johnson, and Gerhard Randers-Pehrson

The Low-Energy Neutron Facility
Stephen A. Marino, Dusan Srdoc, and Gary W. Johnson

Risks from Less than 10 Millisievert: What Do We Really Know? How Can We Learn More?
David J. Brenner

The Risk of Fatal Cancer from Pediatric Computed Tomography
David J. Brenner, Carl D. Elliston, Eric J. Hall, and Walter E. Berdon

A Polymer, Random Walk Model for the Size-Distribution of Large DNA Fragments After High-LET Radiation
David J. Brenner, with Artem Ponomarev and Rainer Sachs, and Lynn Hlatky

Microbeam: Cellular Studies [PDF]

Induction of a Bystander Mutagenic Effect of Alpha Particles on Mammalian
Hongning Zhou, Gerhard Randers-Pehrson, and Tom K. Hei

Intra- and Inter-Cellular Reponses Following Cell-Site-Specific Microbeam Irradiation
Charles R. Geard, Gerhard Randers-Pehrson, Stephen A. Marino, Gloria Jenkins-Baker, Tom K. Hei, Eric J. Hall, and David J. Brenner

Single Alpha-Particle Traversals and Tumor Promoters
Richard C. Miller, Satin Sawant, Gerhard Randers-Pehrson, Stephen A. Marino, Charles R. Geard, Eric J. Hall, and David J. Brenner

Bystander Effect of Radiation on Oncogenic Transformation
Satin G. Sawant, Gerhard Randers-Pehrson, Charles R. Geard, and Eric J. Hall

Role of Oxyradicals in DNA Damage Induced by Cytoplasmic Irradiation in Mammalian Cells
An Xu, Gerhard Randers-Pehrson, and Tom K. Hei

Cellular Studies [PDF]

RBE and Microdosimetry of Low-Energy X Rays
Stephen A. Marino, Dusan Srdoc, Satin Sawant, Charles R. Geard, and David J. Brenner, in collaboration with Zugen Fu

Establishment of an Alpha-Particle-Induced Estrogen-Dependent Breast Cancer Model
Gloria M. Calaf and Tom K. Hei

Genotoxicity Versus Carcinogenicity: Implications From Fiber Toxicity Studies
Tom K. Hei, An Xu, Darren Louie, and Yong-Liang Zhao

Induction of Reactive Oxygen Species by Crocidolite Asbestos in Mammalian Cells
An Xu and Tom K. Hei

Focal Adhesion Motility Revealed in Stationary Fibroblasts
Lubomir B. Smilenov with Alexei Mikhailov, and Robert J. Pelham, Jr., Eugene E. Marcantonia, and Gregg G. Gundersen

Transformation of Human Bronchial Epithelial Cells by the Tobacco-Specific N-Nitrosamine, NNK
Hongning Zhou and Tom K. Hei

Protein Expression in Tumorigenic Human Breast Epithelial Cells Transformed by Alpha Particles
Gloria M. Calaf and Tom K. Hei

Microsatellite Instability in Tumorigenic Human Bronchial Epithelial Cells Induced by Alpha Particles and Fe-56 Ions
Chang Q. Piao and Tom K. Hei

Malignant Transformation of Human Bronchial Epithelial Cells by Arsenite
Chang Q. Piao and Tom K. Hei

Radon, Arsenic, and Mutagenesis
Su X. Liu and Tom K. Hei

Cytogenetic Studies [PDF]

Chromosomal Aberrations in Tumorigenic Human Bronchial Epithelial Cells Transformed by Chrysolite Asbestos
Masao Suzuki, Chang-Qing Piao, and Tom K. Hei

Cytogenetic Effects of Heavy-Ion Beams in Normal Human Bronchial Epithelial Cells
Masao Suzuki, Chang-Qing Piao, and Tom K. Hei

Molecular Studies: Cell-Cycle Checkpoints [PDF]

Physical Interactions Among Human Checkpoint Control Proteins HHUS1p, HRAD1p, and HRAD9p, and Implications for the Regulation of Cell-Cycle Progression
Haiying Hang and Howard B. Lieberman

Two-Hybrid Interactions Between the Human HRAD9p Checkpoint Control Protein and the Tumor Suppressor p53
Sarah J. Rauth, Wei Zheng, and Howard B. Lieberman

Defective G2 Checkpoint by Inactivation of 14-3-3 Gene Influences Telomere Function
Sonu Dhar, Jain Kaung, Jeremy A. Squire, Charles R. Geard, Raymund J. Wellinger, and Tej K. Pandita

Molecular Studies: Damage Responsiveness [PDF]

Ionizing Radiation Activates ATM Kinase Throughout the Cell Cycle
Tej K. Pandita, Howard B. Lieberman, Dae-Sik Lim, Sonu Dhar, Wei Zhen, Yoichi Taya, and Michael B. Kastan

Ataxia Telangiectasia: Chronic Activation of Damage-Responsive Functions is Reduced by Alpha-Lipoic Acid
Magtouf Gatei, Dganit Shkedy, Kum Kum Khanna, Tamar Uziel, Yosef Shiloh, Tej K. Pandita, Martin F. Lavin, and Galit Rotman

Activation of Abl Tyrosine Kinase by Ionizing Radiation Requires ATM But Not DNA-PK
Sanjeev Shangary and Tamara Lataxes, Tej K. Pandita, Guillermo E. Taccioli, and R. Baskaran

Atm Inactivation Results in Aberrant Telomere Clustering During Meiotic Prophase
Tej K. Pandita, Christoph H. Westphal, Melanie Anger, Satin G. Sawant, Charles R. Geard, Raj K. Pandita, and Harry Scherthan

Influence of ATM Function on Telomere Chromatin Structure
Lubomir Smilenov, Sonu Dhar, and Tej K. Pandita

Expression of the Catalytic Subunit of Telomerase in Developing Brain Neurons: Evidence for a Cell-Survival-Promoting Function
Weiming Fu, Michael Killen, and Carsten Culmsee, Sonu Dhar, Tej K. Pandita, and Mark P. Mattson

The Human Homologue of Schizosaccharomyces pombe Rad9 protein, HRAD9p, Interacts with Bcl-2/Bcl-xL and Promotes Apoptosis
Howard B. Lieberman, Haiying Hang, Kevin Hopkins, and Wei Zheng, in collaboration with Kiyoshi Komatsu, Toshiyuki Miyashita, Sandy Cuddeback, Massao Yamada, and Hong-Gang Wang

Molecular Studies Oriented Towards Cancer [PDF]

Identification of THG1 as a Potential Suppressor of Testicular Tumorigenesis
Yuxin Yin

Molecular Mechanism of Radiation-Induced Transformation of Human Bronchial Epithelial Cells by High-LET Radiation
Yong L. Zhao, Chang Q. Piao, and Tom K. Hei

Expression of Transforming Genes and Allelic Imbalance in Human Breast Epithelial Cells Induced by High-LET Radiation
Debasish Roy, Gloria Calaf, and Tom K. Hei

Aberrant Hypermethylation of the 14-3-3 Gene is Associated with Gene Silencing in Breast Cancer
Anne T. Ferguson, Ella Evron, Christopher Umbricht, Tej K. Pandita, Heiko Hermeking, Jeffrey Marks, Andrew Futreal, Martha R. Stampfer, and Saraswati Sukumar

Studies Related to Radiation Therapy [PDF]

A More Robust Biologically Based Ranking Criterion for Treatment
David J. Brenner and Rainer K. Sachs

Tumor Heterogeneity and its Effect on Parameters Estimated Using the Linear-Quadratic Model
David J. Brenner and Eric J. Hall

The Radiological Research Accelerator Facility an NIH-Supported Resource Center [PDF]
Dir, David J Brenner, PhD, DSc; Chief Physicist, Randers-Pehrson, PhD; Mnger, Stephen A Marino, MS

The Radiation Safety Office [PDF]


Updated 10/07/2010


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