2007 Annual Report
Table of Contents

CRR Director: Eric J. Hall
Editor: Howard B. Lieberman
Asst Editor: Jinshuang Lu



The complete 2007 annual report can be downloaded as a PDF as can individual sections of this report from the links below. The table of contents is given below.

For annual reports from previous years click here.

Microbeam Development Studies [PDF]

The Permanent Magnet Microbeam at Columbia University
Guy Garty, Andrew Harken, Gerhard Randers-Pehrson and David J Brenner

Multiphoton Microscopy: Available Imaging Technique at RARAF
Alan W Bigelow, Gerhard Randers-Pehrson and David J Brenner

Under-Dish Detector for the Microbeam at Columbia University
Guy Garty, Chaitanya Medicherla, Gerhard Randers-Pehrson and David J Brenner

X-Ray Microbeam Development at RARAF
Andrew Harken, Gerhard Randers-Pehrson and David J Brenner

Bystander Studies [PDF]

Mitochondrial Function and NF-κB Mediated Signaling in Radiation-Induced Bystander Effects
Hongning Zhou, Vladimir N Ivanov, Yu-Chin Lien, Mercy Davidson and Tom K Hei

Improved Isolation of RNA for Microarray Analysis from Thin Slices of Human Skin Tissue
Sunirmal Paul and Sally A Amundson

Ionizing Radiation-Induced Bystander Effect Activates Protein Kinase C-ε Expression
Burong Hu, Yanrong Su, Peter Grabham, Adayabalam S Balajee and Charles R Geard

Micronucleus Formation in Primary Human Small Airway Epithelial Cells in Response to 05Gy α-Particles
Shanaz A Ghandhi and Sally A Amundson

Improved Preparation of Keratinocytes from 250┬Ám-Thin Tissue Slices for Binucleate Micronucleus Analysis
Alexandre V Mezentsev and Sally A Amundson

Bystander Responses of p53 and c-JUN Proteins in Artificial Epithelial Tissues
Bharat Patel, Brian Ponnaiya, Stephen Marino and Charles R Geard

Biophysical Model of Spatial Patterns of Radiation-Induced Bystander Effects in Three-Dimensional Tissues
Igor Shuryak, Rainer K Sachs and David J Brenner

Molecular Studies [PDF]

Methylation Screening of Betaig-H3 Promoter in Human Lung and Prostate Cancer by Methylation-specific PCR Method
Jinesh N Shah, Genze Shao, Tom K Hei and Yongliang Zhao

HRAD9 is Associated with Tumor Formation in Nude Mice
Aiping Zhu, Xiangyuan Wang and Howard B Lieberman

Comparison between Mrad9 and Mrad9B
Corinne Leloup, Kevin M Hopkins, Xiangyuan Wang, Aiping Zhu, Debra J Wolgemuth and Howard B Lieberman

Alterations in Human Rad9 Protein that Modulate Gamma-Ray and Hydroxyurea Resistance
Kevin M Hopkins, Xiaojian Wang and Howard B Lieberman

Human RAD9 Binds In Vitro and In Vivo to a Palindrome Motif in the Cox-2 Promoter
Xiaojian Wang, Kevin M Hopkins, Yuxin Yin and Howard B Lieberman

TP53-Dependent Radiation Responses in the NCI60 Cell Lines
Sally A Amundson

Histone H2AX is a Critical Factor for Cellular Protection against Genotoxic Agents
Jarah A Meador, Munan Zhao, Yanrong Su, Charles R Geard and Adayabalam S Balajee

Environmental Mutagens Induced Transversions but not Transitions in the Regulatory Region of Mitochondrial DNA
Michael A Partridge, Sarah Huang, Muhammad G Kibriya, Habibul Ahsan, Mercy M Davidson and Tom K Hei

BigH3 Protein Expression as a Marker for Breast Cancer
Gloria M Calaf, C Echibur├║-Chau, Yongliang Zhao and Tom K Hei

The Adaptive Response and Genomic Instability
Brian Ponnaiya and Charles R Geard

High Sensitivity Antigen Detection using Luminescence Substrates in ELISA
Michael A Partridge and Tom K Hei

Nuclear PTEN is a New Guardian of the Genome
Wenhong Shen, Adayabalam S Balajee, Jianli Wang and Yuxin Yin

Cellular Studies [PDF]

Radiosensitization of Melanoma Cells using Inhibition of Antiapoptotic Protein Regulators COX-2 and AKT
Geoffrey E Johnson, Vladimir N Ivanov and Tom K Hei

Increased Susceptibility of Human Small Airway Epithelial Cells to Apoptosis after Long Term Arsenic Treatment
Gengyun Wen, Michael A Partridge, Gloria M Calaf, Jarah A Meador, Burong Hu and Tom K Hei

TGFBI Suppresses Malignant Mesothelioma and Breast Cancer by Prolonging G1-S Transition and De-regulating Cell Invasion
Bingyan Li, Genyun Wen, Jian Tong and Tom K Hei

Human Endothelial Cells in 3D Model Vessel Systems; Differential Effects of High and Low LET Space Radiations
Peter Grabham, Burong Hu, Gloria Jenkins and Charles R Geard

Population-Based Radiology or Radiotherapy Oriented Studies [PDF]

Potential Use of Prophylactic Mammary Irradiation for Reduction of Second Breast Cancers
David J Brenner, Igor Shuryak, Sandra Russo and Rainer K Sachs

Stochastic Mechanistic Model of Second Cancers after Fractionated Radiotherapy
Rainer K Sachs, Igor Shuryak, David J Brenner, Hatim Fakir, Lynn Hlatkyand Philip Hahnfeldt

Immersion Mirau Interferometry
Oleksandra Lyulko, Gerhard Randers-Pehrson and David J Brenner

A Novel, Rapid Method to Characterize the Human Lymphocyte Concentration Based on Quantitative Light Absorption Analysis
Yanping Xu, Helen C Turner,Guy Garty, Gerhard Randers-Pehrson and David J Brenner

Investigation of Oxygen/Nitrogen Resonance Explosive Detector (ONRED) for Screening Baggage: Calculational Approach to its Characteristics and Feasibility
Kenichi Tanaka, Gehard Randers-Pehrson, Yanping Xu, Alan W Bigelow, Stephen A Marino and David J Brenner

Dosimetry using ATOM Phantoms in the Diagnostic and Therapeutic Regimes
Carl D Elliston, Edward L Nickoloff, Cheng-Shie Wuu, Andrew J Einstein, Sandra Russo and David J Brenner

Center for High-Throughput Minimally-Invasive Radiation Biodosimetry (U19) [PDF]

Early Radiation-Induced Gene Expression in Human PBL
Sally A Amundson and Sunirmal Paul

Testing High-Throughput Imaging Systems for Biodosimetry
Guy Garty, Gerhard Randers-Pehrson, Oleksandra V Lyulko and David J Brenner

Automated Robotic System for High-Throughput Radiation Biodosimetry
Guy Garty, Anubha Bhatla, Jian Zhang, Alessio Salerno, Nabil Simaan, Lawrence Y Yao and David J Brenner

Automation of Biodosimetry Assays: Micronuclei and γ-H2AX Foci Formation in Human Lymphocytes
Helen C Turner, Guy Garty, Aparajita Dutta and David J Brenner

Optimization of Lymphocyte Imaging in Filter Bottomed Plates
Oleksandra Lyulko, Helen Turner, Guy Garty, Gerhard Randers-Pehrson and David J Brenner

Radiological Science in the Context of Radiological Terrorism
Carl Elliston, David J Brenner and Eric J Hall

High Throughput Biodosimetry using Gene Expression
Muriel Brengues

DMS-Mass Spec Detection of Biomarkers for Radiation Exposure
Erkinjon Nazarov

Radiation Biodosimetry through Metabolomics
Jeffrey R Idle, Frank J Gonzalez, Erkinjon Nazarov and Albert J Fornace Jr

Informatics, Biostatistics and Data Management
Michael Bittner

Non-Invasive, High Throughput Cytogenetic Biodosimetry for Ionizing Radiation Exposure
Angela J Yoon, Jing Shen, Hui-Chen Wu, Regina Santella

High-Throughput Antibody-Based Assays to Detect Radiation-Induced Changes in Protein Levels
Michael A Partridge and Tom K Hei

Personal TLD Dosimeter in the Form of a Button
Stephen A Marino, Gary W Johnson and David J Brenner

Protein Phosphorylation Based Assays as Biomarkers for Exposure to Ionizing Radiation
Brian Ponnaiya

Radiation-Induced Mitochondrial DNA Damage: A Dosimeter for Radiation Exposure
Hongning Zhou, Yu-Chin Lien, Michael Partridge, Sarah Huang and Tom K Hei

Integrated Microfluidic Visualization on a Microchip for Ultrahigh-Throughput Low-Cost Radiation Biodosimetry
Daniel Attinger, Chee Wei Wong and Samuel K Sia

Phosphoproteome Profiling of Gamma Ray Exposed Lymphocytes
Yongliang Zhao, Gengyun Wen and Tom K Hei

The Radiological Research Accelerator Facility an NIH-Supported Resource Center [PDF]
Dir, David J Brenner, PhD, DSc; Assoc Dir Gerhard Randers-Pehrson, PhD; Mnger, Stephen A Marino, MS

The Radiation Safety Office [PDF]


Updated 10/05/2010


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