Howard B. Lieberman, Ph.D.

Center for Radiological Research           Email:
630 West 168th St., VC 11-219/220      Tel: 212-305-9241
New York, N.Y. 10032                                Fax: 212-305-3229

Research Interests

  • Understanding molecular aspects of radioresistance, chemoresistance and regulation of cell cycle progression in human, mouse and yeast cells.

  • Understanding mechanisms of carcinogenesis.

Laboratory Members

Kevin Hopkins (Senior Staff Associate)
Aiping Zhu (Senior Staff Associate)
Dr. Corinne Leloup (Asso. Research Scientist)
Dr. Constantinos Broustas (Asso. Research Scientist)
Dr. Ana Vasileva (Asso. Research Scientist)
Joshua Daniel Bernstock (Research Worker)

     Academic Training  


B.S., Brooklyn College, 1977


Ph.D., Rutgers University, 1982


Yale University, 1986

   Current Academic and Professional Appointments  

  • Director, Radiation Research Laboratory Core Facility, Herbert Irving Comprehensive Cancer Center, Columbia University

  • Professor of Radiation Oncology, Center for Radiological Research, College of Physicians & Surgeons of Columbia University

  • Professor of Environmental Health Sciences, Mailman School of Public Health, Columbia University

   Select Publications Online  

Click here to download a full CV (requires Adobe Acrobat Reader, available for free download here: )

If you do not find what you are looking for below, try searching for Howard Lieberman on PubMed.

  • Han L, Hu Z, Liu Y, Wang X, Hopkins KM, Lieberman HB and Hang H. Mouse Rad1 deletion enhances susceptibility for skin tumor development. Mol Cancer. 9:67, 2010. [abstract]

  • Hei TK, Zhou H, Ivanov VN, Hong M, Lieberman HB, Brenner DJ, Amundson SA and Geard CR. Mechanism of Radiation-Induced Bystander Effects: A Unifying Model. J. Pharmacy Pharmacol. 60:943-50, 2008. [abstract]

  • Hu Z, Liu Y, Zhang C, Zhao Y, He W, Han L, Yang L, Hopkins KM, Yang X, Lieberman HB and Hang H. Targeted deletion of Rad9 in mouse skin keratinocytes enhances genotoxin-induced tumor development. Cancer Res. 68:5552-61, 2008.[abstract]

  • Lieberman HB. DNA damage repair and response proteins as targets for cancer therapy. Curr Med Chem. 15:360-7, (2008). [abstract]

  • Zhu A, Zhang CX and Lieberman HB. Rad9 has a functional role in human prostate carcinogenesis. Cancer Res. 68:1267-74, (2008). [abstract]

  • Liu YX, Wang J, Guo J, Wu J, Lieberman HB and Yin Y. DUSP1 Is Controlled by p53 during the Cellular Response to Oxidative Stress.Mol Cancer Res. 6:624-33, (2008). [abstract]

  • Kleiman NJ, David J, Elliston CD, Hopkins KM, Smilenov LB, Brenner DJ, Worgul BV, Hall EJ, Lieberman HB. Mrad9 and atm haploinsufficiency enhance spontaneous and X-ray-induced cataractogenesis in mice. Radiat Res. 168:567-73, (2007). [abstract]

  • Pandita RK, Sharma GG, Laszlo A, Hopkins KM, Davey S, Chakhparonian M, Gupta A, Wellinger RJ, Zhang J, Powell SN, Roti Roti JL, Lieberman HB and Pandita TK. Mammalian Rad9 plays a role in telomere stability, S- and G2-phase-specific cell survival, and homologous recombinational repair. Mol Cell Biol. 26:1850-64, (2006). [abstract]

  • Lieberman HB. Rad9, an evolutionarily conserved gene with multiple functions for preserving genomic integrity. J Cell Biochem 97:690-7, (2006). [abstract]

  • Zhu A, Zhou H, Leloup C, Marino SA, Geard CR, Hei TK and Lieberman HB. Differential impact of mouse Rad9 deletion on ionizing radiation-induced bystander effects. Radiat Res 164:655-61, (2005). [abstract]

  • Zhou H, Ivanov VN, Gillespie J, Geard CR, Amundson SA, Brenner DJ, Yu Z, Lieberman HB and Hei TK. Mechanism of radiation-induced bystander effect: role of the cyclooxygenase-2 signaling pathway. Proc Natl Acad Sci U S A 102:14641-6, (2005). [abstract]

  • Smilenov LB, Lieberman HB, Mitchell SA, Baker RA, Hopkins KM and Hall EJ. Combined haploinsufficiency for ATM and RAD9 as a factor in cell transformation, apoptosis, and DNA lesion repair dynamics. Cancer Res 65:933-8, (2005). [abstract]

  • Cell Cycle Checkpoint Control Protocols. Edited by Lieberman HB, Humana Press, Totowa, NJ, (2004).

  • Hopkins KM, Auerbach W, Wang XY, Hande MP, Hang H, Wolgemuth DJ, Joyner AL and Lieberman HB. Deletion of mouse rad9 causes abnormal cellular responses to DNA damage, genomic instability, and embryonic lethality. Mol Cell Biol 24:7235-48, (2004). [abstract]

  • Lieberman HB and Hopkins KM. Methods to induce cell cycle checkpoints. Methods Mol Biol 241:3-10, (2004).

  • Lieberman HB and Yin Y. A novel function for human Rad9 protein as a transcriptional activator of gene expression. Cell Cycle 3:1008-10, (2004). [abstract]

  • Yin Y, Zhu A, Jin YJ, Liu YX, Zhang X, Hopkins KM and Lieberman HB. Human RAD9 checkpoint control/proapoptotic protein can activate transcription of p21. Proc Natl Acad Sci U S A 101:8864-9, (2004). [abstract]

  • Hopkins KM, Wang X, Berlin A, Hang H, Thaker HM and Lieberman HB. Expression of mammalian paralogues of HRAD9 and Mrad9 checkpoint control genes in normal and cancerous testicular tissue. Cancer Res 63:5291-8, (2003). [abstract]

  • Hang H, Zhang Y, Dunbrack RL Jr, Wang C, Lieberman HB. Identification and characterization of a paralog of human cell cycle checkpoint gene HUS1. Genomics. 79(4):487-92 (2002). [abstract]

  • Sawant SG, Zheng W, Hopkins KM, Randers-Pehrson G, Lieberman HB, Hall EJ. The radiation-induced bystander effect for clonogenic survival. Radiat Res. 157(4):361-4 (2002). [abstract]

  • Elder RT, Song XQ, Chen M, Hopkins KM, Lieberman HB, Zhao Y. Involvement of rhp23, a Schizosaccharomyces pombe homolog of the human HHR23A and Saccharomyces cerevisiae RAD23 nucleotide excision repair genes, in cell cycle control and protein ubiquitination. Nucleic Acids Res. 30(2):581-91 (2002). [abstract]

  • Chen MJ, Lin YT, Lieberman HB, Chen G, Lee EY.ATM-dependent phosphorylation of human Rad9 is required for ionizing radiation-induced checkpoint activation. J Biol Chem. 276(19):16580-6 (2001). [abstract]

  • Komatsu K, Wharton W, Hang H, Wu C, Singh S, Lieberman HB, Pledger WJ, Wang HG. PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition. Oncogene. 19(46):5291-7 (2000). [abstract]

  • Hang H, Rauth SJ, Hopkins KM, Lieberman HB. Mutant alleles of Schizosaccharomyces pombe rad9(+) alter hydroxyurea resistance, radioresistance and checkpoint control. Nucleic Acids Res. 28(21):4340-9 (2000). [abstract]

  • Komatsu K, Hopkins KM, Lieberman HB, Wang H. Schizosaccharomyces pombe Rad9 contains a BH3-like region and interacts with the anti-apoptotic protein Bcl-2. FEBS Lett. 481(2):122-6 (2000). [abstract]

  • Hang H, Lieberman HB. Physical interactions among human checkpoint control proteins HUS1p, RAD1p, and RAD9p, and implications for the regulation of cell cycle progression. Genomics. 65(1):24-33 (2000). [abstract]

  • Pandita TK, Lieberman HB, Lim DS, Dhar S, Zheng W, Taya Y, Kastan MB. Ionizing radiation activates the ATM kinase throughout the cell cycle. Oncogene.  19(11):1386-91 (2000). [abstract]

  • Komatsu K, Miyashita T, Hang H, Hopkins KM, Zheng W, Cuddeback S, Yamada M, Lieberman HB, Wang HG. Human homologue of S. pombe Rad9 interacts with BCL-2/BCL-xL and promotes apoptosis. Nat Cell Biol. 2(1):1-6 (2000). [abstract]

  • Hang H, Rauth SJ, Hopkins KM, Davey SK, Lieberman HB. Molecular cloning and tissue-specific expression of Mrad9, a murine orthologue of the Schizosaccharomyces pombe rad9+ checkpoint control gene. J Cell Physiol. 177(2):241-7 (1998). [abstract]

  • Davey S, Han CS, Ramer SA, Klassen JC, Jacobson A, Eisenberger A, Hopkins KM, Lieberman HB, Freyer GA. Fission yeast rad12+ regulates cell cycle checkpoint control and is homologous to the Bloom's syndrome disease gene. Mol Cell Biol.18(5):2721-8 (1998). [abstract]

  • Lieberman HB, Hopkins KM, Nass M, Demetrick D, Davey S. A human homolog of the Schizosaccharomyces pombe rad9+ checkpoint control gene. Proc Natl Acad Sci USA. 93(24):13890-5 (1996). [abstract]

  • Hang H, Hager DN, Goriparthi L, Hopkins KM, Shih H, Lieberman HB. Schizosaccharomyces pombe rad23 is allelic with swi10, a mating-type switching/radioresistance gene that shares sequence homology with human and mouse ERCC1. Gene. 170(1):113-7 (1996). [abstract]

  • Lieberman HB. Extragenic suppressors of Schizosaccharomyces pombe rad9 mutations uncouple radioresistance and hydroxyurea sensitivity from cell cycle checkpoint control. Genetics. 141(1):107-17 (1995). [abstract]

  • Zhao Y, Lieberman HB. Schizosaccharomyces pombe: a model for molecular studies of eukaryotic genes. DNA Cell Biol. 14(5):359-71. Review (1995). [abstract]


Updated 08/17/10