Hongning Zhou,
M.D., M.P.H.

Contact Information

Center for Radiological Research
VC 11-201
630 W. 168th St.
New York, NY 10032

Tel: (212) 305-0846
Fax: (212) 305-3229
email: hz63@columbia.edu

Research Interests

  • Radiation-induced bystander effects

  • Signaling pathways involved in bystander effects

  • Adaptive response and genomic instability

  • Tobacco specific nitrosamine and mutation/transformation

    Academic Training  


M. P.H.:

Chinese Academy of Preventive Medicine, Beijing, 1989-1992                



Shanghai Medical University, Shanghai, 1983-1989


   Current Academic and Professional Appointments  

  • Research Scientist, Center for Radiological Research, College of Physicians & Surgeons of Columbia University Medical Center, New York

   Selected Publications  

  • Partridge MA, Chai Y, Zhou H, Hei TK. High-throughput antibody-based assays to identify and quantify radiation-responsive protein biomarkers. Int J Radiat Biol. 86:321-8, 2010. [abstract]

  • Ivanov VN, Zhou H, Ghandhi SA, Karasic TB, Yaghoubian B, Amundson SA, Hei TK. Radiation-induced bystander signaling pathways in human fibroblasts: A role for interleukin-33 in the signal transmission. Cell Signal. 22:1076-87, 2010. [abstract]

  • Zhou H, Hong M, Chai Y and Hei TK. Consequences of cytoplasmic irradiation: studies from microbeam. J Radiat Res (Tokyo) 50 Suppl A:A59-65, 2009. [abstract]

  • Ivanov VN, Zhou H, Partridge MA and Hei TK. Inhibition of ataxia telangiectasia mutated kinase activity enhances TRAIL-mediated apoptosis in human melanoma cells. Cancer Res 69:3510-9, 2009. [abstract]

  • T.K. Hei, H. Zhou, V.N. Ivanov, M. Hong, H.B. Lieberman, D.J. Brenner, S.A. Amundson, and C.R. Geard. Mechanism of radiation-induced bystander effects: a unifying model. J Pharm Pharmacol. 60: 943-50, 2008. [abstract]

  • H. Zhou, V.N. Ivanov, Y.C. Lien, M. Davidson, and T.K. Hei. Mitochondrial function and nuclear factor-kappaB-mediated signaling in radiation-induced bystander effects. Cancer Res. 68: 2233-40, 2008. [abstract]

  • V.N. Ivanov, M.A. Partridge, G.E. Johnson, S.X. Huang, H. Zhou, and T.K. Hei. Resveratrol sensitizes melanomas to TRAIL through modulation of antiapoptotic gene expression. Exp Cell Res. 314: 1163-76, 2008. [abstract]

  • R. Persaud, H. Zhou, T. K. Hei, and E. J. Hall. Demonstration of a radiation-induced bystander effect for low dose low LET beta-particles. Radiat Environ Biophys. 46: 395-400, 2007. [abstract]

  • V.N. Ivanov, H. Zhou, and T.K. Hei. Sequential treatment by ionizing radiation and sodium arsenite dramatically accelerates TRAIL-mediated apoptosis of human melanoma cells. Cancer Research. 67: 5397-5407, 2007. [abstract]

  • T.K. Hei, H. Zhou, Y. Lien, and Y. Zhao. Mechanism of radiation carcinogenesis: bigH3, COX-2 and beyond. International Congress Series. 1299: 114-120, 2007.

  • H. Zhou, A. Xu, J.A. Gillispie, C.A. Waldren, and T. K. Hei. Quantification of CD59- Mutants in Human-Hamster Hybrid (AL) Cells by Flow Cytometry. Mutation Research. 594: 113-119, 2006. [abstract]

  • H. Zhou, M. Suzuki, R. Persaud, J. Gillispie, G. Randers-Pehrson, and T. K. Hei. Contribution of bystander effects in radiation induced genotoxicity. Acta Med. Nagasaki. 50: 73-77.2005. [abstract]

  • R. Persaud, H. Zhou, S.E. Baker, T.K. Hei, and E.J. Hall. Assessment of low LET radiation-induced bystander mutagenesis in a three-dimensional culture model. Cancer Research. 65: 9876-9882, 2005. [abstract]

  • A. Zhu, H. Zhou, C. Leloup, S.A. Marino, C.R. Geard, T.K. Hei, and H.B. Lieberman. Differential impact of mouse Rad9 deletion on ionizing radiation-induced bystander effects. Radiation Research. 164: 655-661, 2005. [abstract]

  • H. Zhou, V. Ivanov, J.A. Gillispie, C. R. Geard, S. Amundson, D. J. Brenner, H.B. Lieberman, and T. K. Hei. Mechanism of radiation induced bystander effect: role of COX2 signalling pathway. Proceeding of National Academy of Science USA. 102: 14641-14646, 2005. [abstract]

  • H. Zhou, G. Randers-Pehrson, C.A. Waldren and T. K. Hei. Radiation-induced bystander effect and adaptive response in mammalian cells. Advances in Space Research. 34: 1368-1372, 2004. [abstract]

  • M. Suzuki, H. Zhou, C.R. Geard, and T.K. Hei. Effect of medium on chromatin damage in bystander mammalian cells. Radiation Research. 162: 264-269, 2004. [abstract]

  • T.K. Hei, R. Persaud, H. Zhou, and M. Suzuki. Genotoxicity in the eyes of bystander cells. Mutation Research. 568: 111-120, 2004. [abstract]

  • M. Suzuki, H. Zhou, C.R. Geard, and T.K. Hei. Effects of irradiated medium on chromatid aberrations in mammalian cells using double mylar dishes. Biol Sci Space. 18: 110-111, 2004. [abstract]

  • M. Suzuki, H. Zhou, T.K. Hei, C. Tsuruoka, and K. Fujitaka. Induction of a bystander chromosomal damage of He-ion microbeams in mammalian cells. Biol Sci Space. 17: 251-252, 2003. [abstract]

  • H. Zhou, G. Randers-Pehrson, C. R. Geard, D. J. Brenner, E. J. Hall, and T. K. Hei. Interaction between radiation-induced adaptive response and bystander mutagenesis in mammalian cells. Radiation Research. 160: 512-516, 2003. [abstract]

  • H. Zhou, G. Calaf, and T. K. Hei. Malignant Transformation of Human Bronchial Epithelial Cells with Tobacco-Specific Nitrosamine, 4-Methynitrosamine-1-3-Pyridyl-1-Butanone (NNK). International Journal of Cancer. 106: 821-826, 2003. [abstract]

  • A. Xu, H. Zhou, D. Z. Yu, and T. K. Hei. Mechanism(s) of the genotoxicity of crocidolite asbestos in mammalian cells: implication from mutation pattern induced by reactive oxygen species. Environ. Health Perspectives. 110: 1003-1008, 2002. [abstract]

  • H. Zhou, G. Randers-Pehrson, M. Suzuki, C. A. Waldren, E. J. Hall, and T. K. Hei. Genotoxic damage in non-irradiated cells: contribution from bystander effect. Radiation Protection Dosimetry. 99: 227-232, 2002. [abstract]

  • H. Zhou, A. Xu, M. Suzuki, G. Randers-Pehrson, C. A. Waldren, E. J. Hall, and T. K. Hei. The Yin and Yan of bystander versus adaptive response: lessons from the microbeam studies. International Congress Series. 746: 241-247, 2002.

  • H. Zhou, M. Suzuki, C. R. Geard, and T. K. Hei. Effects of irradiated medium with or without cells on bystander cell responses. Mutation Research. 499: 135-141, 2002. [abstract]

  • H. Zhou, G. Randers-Pehrson, M. Suzuki, C. A. Waldren, D. Vannals, G. Chen, J. E. Trosko, and T. K. Hei. Radiation risk to low fluences of particles may be greater than we thought. Proceeding of National Academy of Science USA. 98: 14410-14415, 2001. [abstract]

  • H. Zhou, G. Randers-Pehrson, C.A. Waldren, D. Vannals, E.J. Hall, and T.K. Hei. Induction of Bystander Mutagenic Effect of Alpha Particles in Mammalian Cells. Proceeding of National Academy of Science USA. 97: 2099-2104, 2000. [abstract]

  • H. Zhou, L.X. Zhu, K. Li, and T.K. Hei. Radon, Tobacco Specific Nitrosamine and Mutagenesis in Mammalian Cells. Mutation Research. 430: 145-153, 1999. [abstract]


Updated 04/30/10


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