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Selected publications for Ruth Ottman, Ph.D.

Ottman R, Annegers JF, Hauser WA, and Kurland LT. Higher risk of seizures in offspring of mothers than of fathers with epilepsy. Am J Hum Genet 1988; 43:257 264.

Ottman R. An epidemiologic approach to gene environment interaction. Genetic Epidemiol 1990;7:177 185.

Siris ES, Ottman R, Flaster E, Kelsey JL. Familial aggregation of Paget's disease of bone. J Bone and Mineral Res 1991;6:495 500.

Ottman R, Hauser WA, Susser M. Validity of family history data on seizure disorders. Epilepsia 1993;34:469-475.

Ottman R, Hong S, Lipton RB. Validity of family history data on severe headache and migraine. Neurology 1993;43:1954-1960.

Mayeux R, Stern Y, Ottman R, Tatemichi TK, Tang M-X, Maestre G, Ngai C, Tycko B, Ginsberg H. The apolipoprotein E4 allele in patients with Alzheimer's disease. Ann Neurol 1993;34:752-754.

Ottman R. Epidemiologic analysis of gene environment interaction in twins. Genetic Epidemiol 1994;11:75-86.

Ottman R, Risch N, Hauser WA, Pedley TA, Lee JH, Barker-Cummings C, Lustenberger A, Nagle KJ, Lee KS, Scheuer ML, Neystat M, Susser M, Wilhelmsen K. Localization of a gene for partial epilepsy to chromosome 10q. Nature Genetics 1995;10:56-60.

Ottman R, Annegers JF, Risch N, Hauser WA, Susser M. Relations of genetic and environmental factors in the etiology of epilepsy. Ann Neurol 1996;39:442-449.

Ottman R, Lee JH, Risch N, Hauser WA, Susser M. Clinical indicators of genetic susceptibility to epilepsy. Epilepsia 1996;37:353-361.

Louis ED, Ottman R. How familial is familial tremor? The genetic epidemiology of essential tremor. Neurology 1996;46:1200-1205.

Ottman R. Gene-environment interaction: definitions and study designs. Preventive Medicine 1996;25:764-770.

Ottman R, Hauser WA, Barker-Cummings C, Lee JH, Risch N. Segregation analysis of cryptogenic epilepsy and an empirical test of the validity of the results. Am J Hum Genet 1997;60:667-675.

Ottman R. Genetic epidemiology of epilepsy. Epidemiologic Reviews 1997;19:120-128.

Ottman R, Lee JH, Hauser WA, Risch N. Are generalized and localization-related epilepsies genetically distinct? Arch Neurol 1998;55:339-344.

Tanner CM, Ottman R, Goldman SM, Ellenberg J, Chan P, Mayeux R, Langston JW. Parkinson’s disease in twins: an etiologic study. JAMA 1999;281:341-346.

Louis ED, Ford B, Wendt KJ, Ottman R. Validity of family history data on essential tremor. Movement Disorders 1999;14:456-461.

Winawer MR, Ottman R, Hauser WA, Pedley TA. Autosomal dominant partial epilepsy with auditory features: defining the phenotype. Neurology 2000;54:2173-2176.

Winawer M, Ottman R, Rabinowitz D. Concordance of disease form in kindreds ascertained through affected individuals. Statistics in Medicine 2002;21:1887-1897.

Meisler MH, Kearney J, Ottman R, Escayg A. Identification of epilepsy genes in human and mouse. Ann Rev Genetics 2001;35:567-588.

Winawer M, Martinelli Boneschi F, Barker-Cummings C, Lee JH, Liu J, Mekios C, Gilliam TC, Pedley TA, Hauser WA, Ottman R. Linkage to chromosome 10q24 in 4 new families with autosomal dominant partial epilepsy with auditory features. Epilepsia 2002; 43:55-66.

Kalachikov S, Evgrafov O, Ross B, Winawer M, Barker-Cummings C, Martinelli Boneschi F, Choi C, Morozov P, Das K, Teplitskaya E, Yu A, Cayanis E, Penchaszadeh G, Kottmann AH, Pedley TA, Hauser WA, Ottman R, Gilliam TC. Mutations in LGI1 cause autosomal dominant partial epilepsy with auditory features. Nature Genetics 2002;30:335-341.

Marder K, Levy G, Louis ED, Mejia-Santana H, Cote L, Andrews H, Harris J, Waters C, Ford B, Frucht S, Fahn S, Ottman R. Accuracy of family history of Parkinson’s disease. Neurology 2003;61:18-23.

Winawer MR, Rabinowitz D, Barker-Cummings C, Scheuer ML, Pedley TA, Hauser WA, Ottman R. Distinct genetic influences on generalized and localization-related epilepsy. Epilepsia 2003;44:1176-1182.

Marder K, Levy G, Louis ED, Mejia-Santana H, Cote L, Andrews H, Harris J, Waters C, Ford B, Frucht S, Fahn S, Ottman R. Familial aggregation of early and late-onset Parkinson’s disease. Ann Neurol 2003;54:507-513.

Winawer MR, Rabinowitz D, Pedley TA, Hauser WA, Ottman R. Genetic influences on myoclonic and absence seizures. Neurology 2003;61:1576-1581.

Ottman R, Winawer MR, Kalachikov S, Barker-Cummings C, Gilliam CT, Pedley TA, Hauser WA. LGI1 Mutations in autosomal dominant partial epilepsy with auditory features. Neurology 2004; 62:1120-1126.

Heiman GA, Ottman R, Saunders-Pullman RJ, Ozelius LJ, Risch NJ, Bressman SB. Increased risk for recurrent major depression in DYT1 dystonia mutation carriers. Neurology 2004;63:631-637.