Time Slide Title:
00:02:51.0
Cocaine and Methylphenidate
00:03:01.0
Cocaine and Methylphenidate
00:05:35.4
Positron Emitters for PET
00:06:55.2
PET scan of binding of Cocaine and Methylphenidate in Human Brain
00:09:44.1
Temporal Course of Drug Distribution in Human Brain
00:12:53.9
Drug Pharmacokinetics and the 'High' (Cocaine and Ritalin)
00:15:39.7
Summary of Pharmacokinetics and the 'High'
00:20:11.4
Measuring Dopamine Transporter Occupancy with 11C Cocaine
00:21:46.2
Dopamine Transporter Occupancy by Cocaine (PET)
00:24:33.9
Dopamine Transporter Blockade by Intravenous Cocaine
00:26:11.1
Dopamine Transporter Blockade and Cocaine-Induced 'High'
00:27:08.1
Intravenous Methylphenidate (PET)
00:27:37.8
Dopamine Transporter Blockade by Intravenous Methylphenidate
00:28:09.4
Dopamine Transporter Blockade and Methylphenidate-Induced 'High'
00:28:53.8
Newsweek cover (Ritalin)
00:29:10.9
Occupancy of Dopamine Transporters by Oral Methylphenidate
00:31:25.8
Dopamine Transporter Occupancy by Ritalin
00:32:10.0
Oral Ritalin Produces No or Minimal 'High'
00:32:30.0
Dose Required to Block 50% of the DA Transporters
00:32:44.5
Route of Administration and Reinforcement
00:33:21.9
PET Shows How Fast Drugs Get into the Brain
00:34:07.8
Dopamine Transporter Blockade and Cocaine-Induced 'High'
00:34:53.6
Equal DAT Blockade
00:36:22.0
Using Raclopride to test the Hypothesis
00:37:58.3
Effects of MP on D2 receptor Availability (Bmax/Kd)
00:38:30.6
Relationship between MP-induced Changes in DA D2 Receptors and the 'High'
00:39:34.4
Conclusion
00:40:30.7