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New Administrative Leader Takes Reins at CUMC
Dental Research
| Team Collaborates To Grow Soft Tissue From Stem Cells A team led by Jeremy Mao, DDS, PhD, professor in the College of Dental Medicine, has received a $2.5 million grant from the National Institute of Biomedical Imaging and Bioengineering to use stem cells to engineer soft tissue, a process that may allow scientists to use a patient’s own stem cells to grow tissue for facial reconstruction. The Columbia research team’s goal is to create long-lasting soft tissue implants from mesenchymal stem cells harvested from the patient’s own bone marrow or adipose tissue. Mesenchymal stem cells can differentiate into bone, fat, cartilage and other types of cells. “Our research has shown that mesenchymal stem cells can create tissue that is biocompatible with the host and that the continuous generation of these cells can replenish the implant to reduce shrinkage,” Dr. Mao says. Now, surgeons often graft from the patient’s own tissue, which creates additional wounds. Grafted cells also often are not viable, causing implants to shrink up to 70 percent and lose their shape and volume. Attempts have also been made to use fat cells left over after liposuction, but those cells also have a limited lifespan. The Columbia team of biologists, biomedical engineers, biomaterial scientists, imaging experts and surgeons has shown that human mesenchymal stem cells can create long-lasting implants in mice. The implant is created by placing the stem cells into an FDA-approved scaffold that mimics the conditions needed to turn stem cells into fat cells. Because stem cells have the ability to replicate and differentiate under permissive conditions, they can regenerate the soft tissue, keeping the implant from shrinking. In mice, these cells have successfully created fat cells that could be implanted and retained their size and shape for at least a month. Because the implants can be molded into any size or shape, they could also be used for breast reconstruction. |
